Carbamazepine | 貨號B2401

Inhibitor of neuronal NaV channels

產品介紹: 卡馬西平(Carbamazepine)是神經元電壓門控Na +通道(neuronal voltage-gated Na+ channels)的inhibitor。它顯示抗癲癇活性(anticonvulsant activity)，並在表達GABAA受體α1β2γ2亞型組合的HEK 293細胞中增強GABA誘導的Cl電流。可以通過抑制肌醇合成(inositol synthesis)來誘導自噬(autophagy)。也可作為CYP3A4的體外誘導劑(in vitro inducer)，CYP3A4是肝臟和腸道中主要的人體代謝酶(metabolizing enzyme)。

Alternate Name	5H-Dibenz[b,f]azepine-5-carboxamide, CBZ
Appearance	White solid
CAS #	298-46-4
Molecular Formula	C₁₅H₁₂N₂O
Molecular Weight	236.27
Purity	≥98% by HPLC
Solubility	>20 mg/ml in DMSO
SMILES	C1=CC=C2C(=C1)C=CC3=CC=CC=C3N2C(=O)N
InChi	InChI=1S/C15H12N2O/c16-15(18)17-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)17/h1-10H,(H2,16,18)
InChi Key	FFGPTBGBLSHEPO-UHFFFAOYSA-N
PubChem CID	2554
MDL Number	MFCD00005073
Handling	Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions	-20ºC
Shipping Conditions	Gel Pack