鏈激酶活性測定 | 貨號K2008-100

Streptokinase Activity Assay Kit (Colorimetric) 

產品描述：人鏈激酶(Human Streptokinase)是一種治療藥物(therapeutic drug)，用作纖溶劑(fibrinolytic agent)治療急性心肌梗死患者(acute myocardial infarction)。鏈激酶（Streptokinase , SK）是纖溶酶原激活劑(plasminogen activator)，通過與纖溶酶原結合形成催化活性的鏈激酶-纖溶酶原酶複合物（Plg-SK），從而將纖溶酶原轉化為纖溶酶。實際上，鏈激酶(Streptokinase)是由A組和C組鏈球菌產生的。 SK幫助鏈球菌劫持人纖溶系統中的纖溶酶原，從而消除宿主纖維蛋白的屏障並促進細菌擴散。 SK被列入世界衛生組織（WHO）基本藥物標準清單，並且是治療血栓栓塞性疾病的領先纖維蛋白溶解劑。它具有成本效益並且易於生產。 BioVision的Steptokinase活性測定試劑盒 (BioVision’s Steptokinase Activity Assay Kit, K2008-100) 可用於評估批量培養產生的鏈激酶，及其對血清中纖溶酶原激活的影響。該測定法簡單易行，可通過3個簡單步驟完成。該測定法可在不到60分鐘的時間內檢測到低至3 mU的鏈激酶活性。總體反應如下：纖溶酶原+ SK Plg-SK SK +纖溶酶Plasmin + SK底物Plasmin-SK底物Plasmin + pNA（吸光度405 nm）此產品需由儀器進行定量 ELISA儀器設備請按此 

Cat # +Size	K2008-100
Size	100 assays
Kit Summary	Human Streptokinase is a therapeutic drug and is used as a fibrinolytic agent to treat patients with acute myocardial infarction. Streptokinase (SK) is a plasminogen activator, which works by binding to plasminogen to form a catalytically active streptokinase-plasminogen enzymatic complex (Plg-SK) thereby converting plasminogen to plasmin. In nature, Streptokinase is produced by Group A and Group C Streptococci. SK helps Streptococci in hijacking plasminogen in the human fibrinolytic system thereby dissolving the host fibrin barriers and facilitating bacterial spreading. SK is listed in the World Health Organization (WHO) Model List of essential medicines and is a leading fibrinolytic agent in the treatment of thromboembolic conditions. It is cost-effective and is easy to produce. BioVision’s Steptokinase Activity Assay Kit can be used to evaluate Streptokinase produced in bulk culture and its effect on plasminogen activation in serum. The assay is simple, easy to perform and can be completed in 3 easy steps. The assay can detect as little as 3 mU of Streptokinase Activity in less than 60 min. The overall reaction is as follows: Plasminogen + SK Plg-SK SK + Plasmin Plasmin + SK Substrate Plasmin-SK Substrate Plasmin + pNA (Absorbance 405 nm)
Detection Method	Absorbance, OD 405 nm
Species Reactivity	Streptokinase
Applications	Determination of recombinant Streptokinase activity in bulk preparation for comparison with the in-house bulk-preparation.
Features & Benefits	• Easy to perform and can be completed in 3 easy steps • Can detect as little as 3 mU of Streptokinase Activity in less than 60 min • Simple
Kit Components	Streptokinase pNA Standard Plasminogen SK Assay Buffer SK Substrate Buffer SK Substrate

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