Zanubrutinib |Btk抑制劑 貨號B2512-1
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特點
產品介紹: Zanubrutinib（BGB3111）是一種有效的，選擇性的和口服的Btk抑制劑 (Btk inhibitor) 。與依魯替尼(Ibrutinib)相比，針對包括ITK在內的一系列激酶顯示出更多受限制的脫靶活性(off-target activities)。 BGB-3111與BTK選擇性結合併抑制其活性，並阻止B細胞抗原受體（BCR）信號傳導途徑的激活。
| Alternate Name | (7S)-4,5,6,7-Tetrahydro-7-[1-(1-oxo-2-propen-1-yl)-4-piperidinyl]-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide; BGB-3111; (S)-Zanubrutinib; BGB3111 |
| Appearance | White to off-white solid |
| CAS # | 1691249-45-2 |
| Molecular Formula | C₂₇H₂₉N₅O₃ |
| Molecular Weight | 471.56 |
| Purity | ≥98% by HPLC |
| Solubility | >50 mg/ml in DMSO |
| SMILES | C=CC(=O)N1CCC(CC1)C2CCNC3=C(C(=NN23)C4=CC=C(C=C4)OC5=CC=CC=C5)C(=O)N |
| InChi | InChI=1S/C27H29N5O3/c1-2-23(33)31-16-13-18(14-17-31)22-12-15-29-27-24(26(28)34)25(30-32(22)27)19-8-10-21(11-9-19)35-20-6-4-3-5-7-20/h2-11,18, 22,29H,1,12-17H2,(H2,28,34) |
| InChi Key | RNOAOAWBMHREKO-UHFFFAOYSA-N |
| PubChem CID | 135905454 |
| Handling | Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure. |
| Storage Conditions | -20ºC |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |