Caspase 1抗體 | Caspase 1 Antibody貨號6687

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特點
Caspase 1 Antibody
產品描述: Caspase-1(也稱為ICE)是胱天蛋白酶半胱氨酸(caspase-family of cysteine proteases)蛋白酶家族(caspase-family)的prototypical member。 Caspase-1 不活化(inactive) 45kDa pro-enzyme存在於細胞中。 pro-enzyme通過蛋白水解(proteolysis)使前proenzyme成熟,產生大的(20kDa)和小的(10kDa)亞基 (subunits) 。 活性caspase-1是由兩個大的和兩個小亞基組成的異四聚體 (heterotetramer)。 迄今為止,人們對半胱天冬酶-1活化 (caspase-1 activation)的調節機制和半胱天冬酶-1(caspase-1) 在細胞凋亡(apoptosis)中的作用知之甚少。在THP-1細胞中,大部分半胱天冬酶-1(caspase-1)以無活性酶原形式(inactive proenzyme form)存在。

| Antibody Target | Caspase 1 |
|---|---|
| Alternate Name | CASP-1, Interleukin-1 beta convertase, IL-1BC, Interleukin-1 beta-converting enzyme, ICE, IL-1 beta-converting enzyme |
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | Rabbit IgG |
| Immunogen | Mouse Recombinant Caspase 1, Cat # 1181 |
| Accession # | P29452 |
| Gene ID | 12362 |
| Appearance | Colorless liquid |
| Concentration | 0.5 mg/ml |
| Formulation | 100 µg (0.5 mg/ml) of antibody in PBS pH 7.2, 0.01 % BSA, 0.03 % ProClin®, and 50 % glycerol. |
| Purification | Affinity Purified Antibody |
| Species Reactivity | Human, Mouse |
| Application | Western blot |
| Positive Control | Western Blot: Jurkat cell lysate, mouse muscle lysate, recombinant protein |
| Application & Usage | Western blot: 1-4 µg |
| Handling | The antibody solution should be gently mixed before use. |
乾浴加熱水浴槽 | Finnpipette F3 微量分注器 | 試管振盪器 Vortex Mixer | Genereach迷你型微量離心機 | ELISA儀器
