MLN8237抑制劑 | CAS #1028486-01-2貨號2718-25
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特點
產品介紹: MLN8237是Aurora kinase A的有效選擇性抑制劑（IC 50 = 1.2 nM）。 它顯示Aurora激酶A的選擇性比Aurora激酶B高200倍以上。顯示抗腫瘤活性(antineoplastic activity)。
| Alternate Name | 4-[[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2-methoxy-benzoic acid; Alisertib |
| Appearance | Crystalline solid |
| CAS # | 1028486-01-2 |
| Molecular Formula | C₂₇H₂₀ClFN₄O₄ |
| Molecular Weight | 518.9 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (>40 mg/ml) |
| SMILES | COC1=C(C(=CC=C1)F)C2=NCC3=CN=C(N=C3C4=C2C=C(C=C4)Cl)NC5=CC(=C(C=C5)C(=O)O)OC |
| InChi | InChI=1S/C27H20ClFN4O4/c1-36-21-5-3-4-20(29)23(21)25-19-10-15(28)6-8-17(19)24-14(12-30-25)13-31-27(33-24)32-16-7-9-18(26(34)35)22(11-16)37-2/h3-11,13H,12H2,1-2H3,(H,34,35)(H,31,32,33) |
| InChi Key | ZLHFILGSQDJULK-UHFFFAOYSA-N |
| PubChem CID | 24771867 |
| Handling | Protect from air and light |