BDNF腦源性神經營養因子抗體 | 貨號6725

BDNF Antibody (CT) 產品描述：神經營養因子 (Neurotrophins) 在發育過程中扮演調節神經元(neurons)自然發生的細胞死亡的作用。原型神經營養因子 (prototype neurotrophin) 是神經生長因子（NGF），最初在20世紀50年代被發現為可溶性肽(soluble peptide)，促進交感神經節的存活和神經突向外生長。 已經鑑定了三種另外的結構同源的神經營養因子。 這些包括腦源性神經營養因子/血清腦源性神經營養因素（brain-derived neurotrophic factor , BDNF），神經營養因子-3（neurotrophin-3 , NT-3）和神經營養因子-4（neurotrophin-4, NT-4）（也稱為NT-5）。 這些不同的神經營養因子刺激不同但部分重疊的神經元群體的體外存活。 已經鑑定了神經營養因子介導其活性的細胞表面受體。 例如，Trk A受體是NGF的優先受體，但也結合NT-3和NT-4。 Trk B受體同樣良好地結合BDNF和NT-4，並且在較小程度上結合NT-3，而Trk C受體僅結合NT-3。

Cat # +Size	6725-100
Size	100 μl
Antibody Target	BDNF
Alternate Name	BDNF; Brain-derived neurotrophic factor; Abrineurin
Host	Rabbit
Antibody Type	Polyclonal
Isotype	Rabbit IgG
Immunogen	This BDNF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 206-236 amino acids from the C-terminal region of human BDNF.
Accession #	P23560
Gene ID	627
Appearance	Colorless liquid
Formulation	100 µl of antibody in PBS with 0.09% (W/V) sodium azide
Purification	This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Species Reactivity	Human
Application	Western blot, IHC
Positive Control	Western blot: CEM cell line, IHC: human brain tissue, FACS: CEM cells, IF: NCI-H460 cells
Application & Usage	Western blot: ~1:1000, IHC: ~1:10–1:50, IF: ~1:10–1:50, FC: ~1:10–1:50.
Handling	The antibody solution should be gently mixed before use.
Storage Conditions	-20 °C
Shipping Conditions	Gel Pack