EGFR (Panitumumab)抗體 | 貨號A1050

Anti-EGFR (Panitumumab), Humanized AntibodyMonoclonal human IgG2k antibody against human EGFR

產品描述：帕尼單抗 (Panitumumab)是抗表皮生長因子受體（EGFR）的人單克隆抗體。 EGFR是I型受體酪氨酸激酶亞 (type I receptor tyrosine kinases) 家族的成員，包括EGFR（HER1，c-ErbB-1），HER2 / neu，HER3和HER4。 EGFR是一種跨膜糖蛋白 (transmembrane glycoprotein)，在許多正常上皮組織中組成型表達，包括皮膚 (skin) 和毛囊 (hair follicle)。在許多人類癌症中也檢測到EGFR的過表達，包括結腸 (colon) 和直腸 (rectum)癌症。Panitumumab帕尼單抗特異性地和選擇性地結合EGFR，阻止活化配體（例如EGF和轉化生長因子-α）的結合。這種結合導致必需的下游信號傳導途徑的阻斷，已知這些途徑控制多種組織中正常和腫瘤細胞類型的細胞凋亡 (apoptosis)，增殖 (proliferation) 和分化 (differentiation) 。

Cat # +Size	A1050-100
Size	100 µg
Antibody Target	EGFR
Alternate Name	Vectibix
Host	Recombinant
Antibody Type	Monoclonal
Isotype	Human IgG2 kappa
Immunogen	EGFR
Accession #	Q147T7
Gene ID	1956
Appearance	Colourless liquid
Concentration	1 mg/ml
Formulation	100 ug of antibody in Phosphate buffered saline, pH 7.4.
Purification	human IgG2k was expressed in a mouse cell line. IgG was purified from mouse cell culture supernatant by protein A chromatography.
Species Reactivity	Human
Application	Neutralization, ELISA
Application & Usage	Neutralization : 1-20μg/ml; ELISA: 1μg/ml
Handling	The antibody solution should be gently mixed before use.