PT-2385抑制劑 | 貨號B1920

A potent ad selective inhibitor of hypoxia inducible factor (HIF-2α)

產品描述：PT-2385是一種有效性選擇性缺氧誘導因子（HIF-2α）抑制劑，具有潛在的抗腫瘤活性。 PT-2385選擇性地破壞HIF-2α與HIF-1β的異二聚化。 在阻斷透明細胞腎細胞癌（ccRCC）中的癌細胞生長，增殖和腫瘤血管生成方面非常有效。

Alternate Name	(S)-3-((2,2-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile; PT2385
Appearance	Crystalline solid
CAS #	1672665-49-4
Molecular Formula	C₁₇H₁₂F₃NO₄S
Molecular Weight	383.34
Purity	≥98% by HPLC
Solubility	DMSO
SMILES	CS(=O)(=O)C1=C2C(C(CC2=C(C=C1)OC3=CC(=CC(=C3)C#N)F)(F)F)O
InChi	InChI=1S/C17H12F3NO4S/c1-26(23,24)14-3-2-13(12-7-17(19,20)16(22)15(12)14)25-11-5-9(8-21)4-10(18)6-11/h2-6,16,22H,7H2,1H3/t16-/m0/s1
InChi Key	ONBSHRSJOPSEGS-INIZCTEOSA-N
PubChem CID	91754484
Handling	Protect from air and light