2-Deoxy-D-Glucose | 貨號B1048-500 ( ABCAM ab142242)

A competitive inhibitor of glucose metabolism.

產品描述：2-Deoxy-D-Glucose 2-脫氧-D-葡萄糖是一種葡萄醣類似物(glucose analog)，長期以來一直被認為是葡萄糖代謝(glucose metabolism)的競爭性抑制劑(competitive inhibitor)。 轉運到細胞中後，2-DG被己糖激酶(phosphorylated by hexokinase)磷酸化為2-DG-P。 然而，與G-6-P不同，2-DG-P不能被磷酸己糖異構酶(phosphohexose isomerase)進一步代謝，磷酸己糖異構酶將G-6-P轉化為果糖-6-磷酸。 2-脫氧葡萄糖-P被捕獲並積聚在細胞中，主要在己糖激酶磷酸化葡萄糖的步驟中導致糖酵解的抑制。 通過2-DG抑制該限速步驟導致細胞ATP耗盡，導致細胞週期進程的阻斷和體外細胞死亡(cell cycle progression)。

ab142242 has been referenced in 3 publications.

• Non-metabolizable glucose analog and glycolytic inhibitor. Antitumor agent.
• CAS Number: 154-17-6
• Purity: > 97%
• Soluble in ethanol to 50 mM and in DMSO to 50 mM
• Form / State: Solid
• Source: Synthetic

Alternate Name	2-Deoxy-D-arabinohexose, 2-Deoxyglucose
Appearance	White to off-white solid
CAS #	154-17-6
Molecular Formula	C₆H₁₂O₅
Molecular Weight	164.16
Purity	≥98% GC
Solubility	H2O (>15 mg/ml) or DMSO (>15 mg/ml)
SMILES	C1C(C(C(OC1O)CO)O)O
InChi	InChI=1S/C6H12O5/c7-2-4-6(10)3(8)1-5(9)11-4/h3-10H,1-2H2/t3-,4-,5?,6+/m1/s1
InChi Key	PMMURAAUARKVCB-CERMHHMHSA-N
PubChem CID	439268
MDL Number	MFCD00151328
Handling	Protect from air and moisture
Storage Conditions	4°C
Shipping Conditions	Gel Pack