β澱粉樣蛋白1-42（Aβ42）配體篩選檢測（螢光） | 貨號K570-100

Beta Amyloid 1- 42 (Aβ42) Ligand Screening Assay Kit (Fluorometric)

產品描述：阿爾茨海默病是一種慢性神經退行性疾病。它是由患有這種疾病的患者的大腦中發現的澱粉樣蛋白斑的積累引起的。斑塊主要由β澱粉樣蛋白（Aβ）肽組成：Aβ（1-40）和Aβ（1-42）。最近的研究表明，患有阿爾茨海默病的患者腦組織，腦脊液（CSF）和血漿中存在兩種β澱粉樣蛋白肽（Aβ（1-40）和Aβ（1-42））。特別地，聚集的Aβ（1-42）被認為是用於診斷阿爾茨海默氏病的有效生物標誌物。因此，篩選可預防聚集的Aβ42配體對於開發潛在的治療方法至關重要。在BioVision的β澱粉樣蛋白1-42（Aβ42）配體篩選試劑盒中，染料與聚集的澱粉樣肽的β折疊結合，產生強螢光產物（Ex / Em：440 / 490nm）。在Aβ42配體存在下，該反應被阻止/消除，導致螢光減少或完全喪失。該試驗可用於篩選Aβ42配體以開發抗阿爾茨海默病的潛在治療劑。測定簡單，可靠和高通量的適應性篩選測定。

Cat # +Size	K570-100
Size	100 assays
Kit Summary	• Detection method – Fluorescence (Ex/Em 440/490 nm) • Species reactivity – Eukaryotes • Applications – Screening of drugs and novel ligands for interaction with Beta Amyloid 1-42 (Aβ42
Detection Method	Fluorescence (Ex/Em 440/490 nm)
Species Reactivity	Aβ42
Applications	• Rapid, high-throughput screening of drugs and novel ligands. • Development of structure-activity relationship (SAR) models to predictAβ42/ligand interaction liability of novel compounds.
Features & Benefits	• Simple, highly sensitive, high-throughput compatible • Rapid screening of Aβ42 ligands • Kit includes the Aβ42 ligand control and a stable, Aβ42 peptide
Kit Components	• Aβ42 Assay Buffer • Aβ42 Probe (100X, in DMSO) • Aβ42 Peptide • Aβ42 Inhibitor (100X, in DMSO) • 10 mM NaOH