Senescence衰老檢測試劑盒 | Senescence Detection Kit貨號K320-250

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Senescence衰老檢測試劑盒 | 貨號K320-250

Senescence Detection Kit

產品描述：Senescence衰老被認為是Tumor suppressive mechanism 腫瘤抑制機制 ( tumor suppressive mechanism) 和衰老 (aging) 的根本原因。衰老 (Senescence) 代表了一種被arrested拘留的狀態，其中細胞保持 viable活力，但沒有被serum血清或培養物中的通道刺激divide分裂。 Senescent cells衰老細胞表現出細胞大小(cell size)的增加，衰老相關β-半乳糖苷酶（ β-galactosidase, SA-β-Gal）活性的表現，以及基因表達模式的改變 (gene expression) 。 Senescence detection kit 衰老檢測試劑盒, K320, 設計用於histochemically組織化學檢測培養細胞和組織切片中的SA-β-Gal活性，這是衰老細胞的已知特徵。 SA-β-Gal僅存在於衰老細胞中，並且在presenescent，靜止 (quiescent) 或永生細胞(immortal cells) 中不存在。

Cat # +Size	K320-250
Size	250 Stainings
Species Reactivity	Mammalian
Applications	The Senescence Detection Kit is designed to histochemically detect specific senescence marker in distinct pH in cultured cells and tissue sections.
Features & Benefits	• Simple procedure; takes around than 30 minutes • Fast and convenient • The specific histochemical marker is only present in senescent cells and is not found in presenescent, quiescent or immortal cells.
Kit Components	• Fixative Solution (1X) • X-Gal (150 mg, lyophilized) • Staining Solution (1X) • Staining Supplement (100X)
Storage Conditions	-20°C

引用文獻

Yi, Zhang et al. (2017) Effects of Nonsteroidal Anti-inflammatory Drugs on the Self-renewal Capacity of Blast Progenitors in Hematological Malignancies, J Environ Pathol Toxicol Oncol. 2017;36(1):15-27.

Lukasova, Emilie et al. (2017) Loss of lamin B receptor is necessary to induce cellular senescence, Biochem J. 2017 Jan 15;474(2):281-300.

Sasaki, Sheng-Hsuan et al. (2017) Sialylation regulates myofibroblast differentiation of human skin fibroblasts, Stem Cell Res Ther. 2017 Apr 18;8(1):81.

Chem et al., Ganglioside GM1 Contributes to the State of Insulin Resistance in Senescent Human Arterial Endothelial Cells. J. Biol. Chem., Oct 2015; 290: 25475 – 25486.

Li et al., p53 enables metabolic fitness and self-renewal of nephron progenitor cells. Development, Apr 2015; 142: 1228 – 1241.

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