Mouse Anti-GSK-3α-HRP | 貨號10910-05   規格1.0 mL

產品介紹: 糖原合成酶激酶-3（GSK-3）是磷酸化糖原合酶從而使其失活的蛋白質絲氨酸激酶。 胰島素刺激GSK-3磷酸化位點的糖原合酶的去磷酸化，並隨後嚴重抑制GSK-3導致糖原合成的刺激。 GSK-3信號通過兩種同工型，GSK-3α和GSK-3β進行。 兩種同種型在它們的催化結構域內具有97％的序列相似性。 GSK-3也被證明在蛋白質合成，細胞粘附，細胞增殖，細胞分化，微管動力學和細胞運動中起作用。

Lane 1 – Jurkat
Lane 2 – NIH 3T3
Total cell lysates were resolved by electrophoresis, transferred to PVDF membrane, and probed with Mouse Anti-GSK-3α-HRP (SB Cat. No. 10910-05). Proteins were visualized using chemiluminescent detection.

Clone	SBGSK3α4
Isotype	Mouse (BALB/c) IgG2aκ
Isotype Control	Mouse IgG2a-HRP
Immunogen	Recombinant N-terminal GSK-3α
Specificity	Human/Mouse GSK-3α
Alternalte Name(s)	Glycogen synthase kinase-3 alpha
Description	Glycogen synthase kinase-3 (GSK-3) is a protein serine kinase that phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK-3 and subsequently inhibits GSK-3 acutely leading to the stimulation of glycogen synthesis. GSK-3 signaling is performed by two isoforms, GSK-3α and GSK-3β. The two isoforms share 97% sequence similarity within their catalytic domains. GSK-3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics, and cell motility.
Format/Conjugate	HRP (Horseradish Peroxidase)
Buffer Formulation	Supplied in a stock solution of 50% glycerol/50% PBS, pH 7.4; No preservative added
Volume	1.0 mL
Storage & Handling	Store at 2-8°C Please refer to product specific SDS