Nimbolide  5-25mg包裝 貨號1891 (Abcam ab142138) 

An anticancer agent

來自Azadirachta indica（Neem tree）的萜類內酯，顯示各種生物活性，包括抗瘧疾和抗癌活性。裸露酚化合物通過三種不同的機制使結腸癌細胞對TRAIL誘導的細胞凋亡敏感：活性氧和ERK-mediated上游調控DR5和DR4，下游調控細胞存活蛋白，上調控凋亡蛋白p53和Bax。

Alternate Name	(4α,5α,6α,7α,15β,17α)-7,15:21,23-Diepoxy-6-hydroxy-4,8-dimethyl-1-oxo-18,24-dinor-11,12-secochola-2,13,20,22-tetraene-4,11-dicarboxylic Αcid γ-lactone Methyl Ester; CCRIS 5723, NSC-309909
Appearance	White to off-white solid
CAS #	25990-37-8
Molecular Formula	C₂₇H₃₀O₇
Molecular Weight	466.52
Purity	≥98% by TLC
Solubility	DMSO (~50 mM) or Ethanol (~ 8 mM)