KLF4單株抗體 |Biovision貨號5300-100

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KLF4單株抗體 |貨號5300-100
產品介紹: KLF4是一種轉錄因子,其作為轉錄激活因子和阻遏物;扮演調節多種細胞類型的增殖和分化的作用。 KLF4在胚胎髮育中的作用提示其可能在幹細胞的產生中有用,所述幹細胞可能在細胞替代療法中用於治療幾種變性疾病。可以通過在小鼠成纖維細胞中表達KLF4和轉錄因子POU5F1,Sox2和Lin28以及c-Myc來產生稱為誘導多能幹(iPS)細胞的人工幹細胞。最近,實驗已經證明iPS細胞可以使用表達KLF4,Sox2,POU5F1和c-Myc的表達質粒產生,消除了對病毒導入的需要,從而解決了再生醫學中iPS細胞的潛在用途的安全性問題。 KLF4直接與POU5F1和Sox2在iPS和ES細胞中相互作用,並激活靶NANOG基因。

| Size | 100 µg |
| SKU+Size | 5300-100 |
| Antibody Target | KLF4 |
| Alternate Name | Kruppel-like factor 4, GKLF, EZF |
| Host | Mouse |
| Antibody Type | Monoclonal |
| Isotype | Mouse IgG1 |
| Immunogen | KLF4 antibody was raised against a 20 amino acid peptide near the carboxy terminus of human KLF4. |
| Accession # | O43474 |
| Gene ID | 9314 |
| Appearance | Colorless liquid |
| Concentration | 1 mg/ml |
| Formulation | 100 µg (1 mg/ml) in 1X PBS containing 0.02 % sodium azide. |
| Purification | Affinity chromatography purified via peptide column |
| Species Reactivity | Human, Mouse, Rat |
| Application | Western blot, ELISA |
| Positive Control | Western Blot: Mouse liver tissue lysate |
| Application & Usage | Western Blot: 1 – 2 μg/ml, ELISA. However, the optimal conditions should be determined individually. |
