單胺氧化酶A高通量篩選分析套組 | Monoamine Oxidase A (MAO-A) Inhibitor Screening Kit 貨號K796
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商品: Monoamine Oxidase A (MAO-A) Inhibitor Screening Kit (Fluorometric) 單胺氧化酶A高通量篩選分析套組
產品規格: 胺氧化酶A高通量篩選分析套組 貨號K796-100 | 100個分析 Monoamine Oxidase A (MAO-A) Inhibitor Screening Kit
產品描述: Monoamine oxidases單胺氧化酶（MAO，EC 1.4.3.4）是可以氧化多種內源性伯胺的酶家族。以它們的substrate底物，inhibitor specificity抑制特異性和tissue localization組織定位；鑑定了兩種同種型，MAO-A和MAO-B。MAO-A可以氧化伯胺如5-羥色胺和去甲腎上腺素。MAO-A是線粒體結合的酶，其在整個腦和其他組織中普遍表達。它與恐慌，焦慮和抑鬱有關。幾種MAO-A特異性抑制劑如氯吉林，溴溴胺，甲苯磺隆，四吲哚等已經用作抗抑鬱藥，但由於副作用，它們的使用受到限制。BioVision的MAO-A抑製劑篩選試劑盒提供了快速，簡單，靈敏和可靠的測試，適用於MAO-A抑制劑的高通量篩選。 該測定基於H 2 O 2的螢光檢測，H 2 O 2是在MAO底物的氧化脫氨期間產生的副產物。
| Size | 100 assays |
| SKU+Size | K796-100 |
| Detection Method | Fluorescence (Ex/Em = 535/587 nm) |
| Applications | Screening/studying/characterizing MAO-A inhibitors |
| Features & Benefits | • Rapid & sensitive • High-throughput assay to screen/study/characterize potential inhibitors of monoamine oxidase A • Includes Inhibitor Control [Clorgyline] |
| Kit Components | • MAO-A Assay Buffer • OxiRed™ Probe (in DMSO) • MAO-A Enzyme (Lyophilized) • MAO-A Substrate (Lyophilized) • Developer (Lyophilized) • Inhibitor Control (Clorgyline) (Lyophilized) |