Fc Silent™ Antibodies: Turning down the background noise

Fc Silent| 抗體 | 只要訊號不要雜訊 (Engineered Fc Domain)

Absoluted Antibody 提供一系列抗體商品，其中Fc Silent™ Antibodies系列；能有效降低非特異性Fc結合。Fc Silent™技術，為應用生物工程技術，將Fc receptors (FcγR, FcR)點突變，進而中止抗體與ADCC的功能；有效降低Fc所造成的背景訊號。Fc Silent™抗體應用於免疫細胞時flow cytometry、immunohistochemistry (IHC)資料顯示，有效降低非特異性之Fc結合，所造成的背景值。(訂購抗體前，請確認選擇抗體是否有Fc Silent™修飾標誌)

 PD-L1抗體Anti- PD-L1.抗體 | 貨號Ab00377-23.0

Species and Isotype: Rabbit IgG, lambda
Clone Number: alphaPD-L1
UniProt Accession Number of Target Protein: Q9EP73
Alternative Name(s) of Target: Programmed Cell Death Ligand 1
Published Application(s): ELISA; Blocking
Published Species Reactivity: Mouse
Immunogen: Mouse recombinant PD-L1.
Specificity: The antibody binds to murine PD-L1 with a Kd of 0.71 nM.
Application Notes: The antibody binds to PD-L1, a costimulatory signal protein necessary for T-cell proliferation.
Antibody First Published in:
Drees et al. Soluble production of a biologically active single-chain antibody against murine PD-L1 in Escherichia coli. Protein Expression and Purification, 2014; 94:60-66 PMID:24215864

Product	Expected Species Reactivity	Isotype/Format	Modification	Products
Ab00377-1.1 Anti-PDL1 [alphaPD-L1]	Mouse	Mouse IgG1		Purified
Ab00377-1.4 Anti-PDL1 [alphaPD-L1]	Mouse	Mouse IgG1	Fc Silent™	Purified
Ab00377-23.0 Anti-PDL1 [alphaPD-L1]	Mouse	Rabbit IgG		Purified
Ab00377-1.7 Anti-PDL1 [alphaPD-L1]	Mouse	Mouse F(ab’)2	AbFab2™	PurifiedPurified