抗Mouse Anti-Human CD107a-BIOT抗體 | 貨號9835-08 | 規格100 TEST (具Biotin標誌)

細胞免疫專家極力推薦SouthernBiotech高品質二級抗體

美國抗體生產商Southern Biotech於1982年，由UAB細胞免疫專家Dr. Max Cooper與實驗室成員共同創立。SouthernBiotech致力於生產高品質二級抗體。物種種類齊全，包括有Bovine、Canine、Chicken、Cynomolgus、Donkey、Equine、Feline、Goat、Guinea Pig、Hamster、Human、Monkey、Mouse、Porcine、Rabbit、Rat、Rhesus、Sheep、Turkey。具有螢光物質（FITC、PE、APC、SPRD、PE/CY5.5、APC/CY5.5、Spectral Red、Alexa 488、Alexa 647、Pacific Blue）各種螢光標誌、另具酵素（HRP、AP）、或未標誌及Low Endotoxin/Azide Free（LE/AF）等標定。

CD107a，也稱為溶酶體相關膜蛋白 1 (lysosomal-associated membrane protein 1, LAMP-1)，是一種高度糖基化的 I 型跨膜蛋白(glycosylated type I transmembrane protein)，構成溶酶體膜( lysosomal membranes)上的主要唾液酸糖蛋白(sialoglycoproteins)。它是 Galaptin（一種存在於細胞外基質中的 S 型凝集素）的配體，通過識別乙醯基乳糖胺寡糖鏈，並且是 E-選擇素介導( E-selectin-mediated )的細胞粘附(cell adhesion)的配體。 CD107a 由活化的 T 細胞( T cells)、巨噬細胞(macrophages)、樹突狀細胞(dendritic cells)、活化的血小板( activated platelets)、扁桃體上皮和一些腫瘤細胞系（包括 U937 和 KG1a）表達。它也是一種廣泛表達的細胞內抗原。 LAMP-1 (lysosomal-associated membrane protein 1, LAMP-1)可能通過形成溶酶體水解酶( lysosomal hydrolases)屏障來保護溶酶體膜的內表面。腫瘤細胞系表面上 CD107a 和 CD107b 的上調與其增強的轉移潛力相關，其中它們可能增加與細胞外基質(extracellular matrix)和內皮( endothelium)的粘附。

Mouse Anti-Human CD107a-BIOT抗體產品資料

Clone	H4A3
Isotype	Mouse (BALB/c) IgG1κ
Isotype Control	Mouse IgG1-BIOT
Immunogen	Human adherent peripheral blood cells
Specificity	Human/Rhesus/African Green Monkey/Pigtail Macaque/Sooty Mangabey CD107a
Alternalte Name(s)	LAMP-1, lysosome-associated membrane protein 1
Description	CD107a, also known as lysosomal-associated membrane protein 1 (LAMP-1), is a heavily glycosylated type I transmembrane protein that constitutes the major sialoglycoproteins on lysosomal membranes. It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains, and is a ligand for E-selectin-mediated cell adhesion. CD107a is expressed by activated T cells, macrophages, dendritic cells, activated platelets, tonsillar epithelium, and some tumor cell lines, including U937 and KG1a. It is also a widely expressed intracellular antigen. LAMP-1 may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases. The upregulation of both CD107a and CD107b on the surface of tumor cell lines has been associated with their enhanced metastatic potential where they may increase adhesion to extracellular matrix and endothelium.
Format/Conjugate	BIOT (Biotin)
Buffer Formulation	Supplied in PBS/NaN3
Volume	1.0 mL
Storage & Handling	Store at 2-8°C Please refer to product specific (M)SDS

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