Fc Silent™ Antibodies: Turning down the background noise

Fc Silent| 抗體 | 只要訊號不要雜訊 (Engineered Fc Domain)

Absoluted Antibody 提供一系列抗體商品，其中Fc Silent™ Antibodies系列；能有效降低非特異性Fc結合。Fc Silent™技術，為應用生物工程技術，將Fc receptors (FcγR, FcR)點突變，進而中止抗體與ADCC的功能；有效降低Fc所造成的背景訊號。Fc Silent™抗體應用於免疫細胞時flow cytometry、immunohistochemistry (IHC)資料顯示，有效降低非特異性之Fc結合，所造成的背景值。(訂購抗體前，請確認選擇抗體是否有Fc Silent™修飾標誌)

產品介紹 假性狂犬病抗體Anti-Glycoprotein H [A13-d6.3] 抗體 | 產品描述:

Description: Recombinant monoclonal antibody to Glycoprotein H. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybdridoma A13-d6.3.
UniProt Accession Number of Target Protein: A0A142I9U7
Alternative Name(s) of Target: d6.3; gH; Envelope glycoprotein H Immunogen: d6.3 was generated by immunizing mice with PrV.
Specificity: d6.3 Fab fragment binds to the core fragment of the PrV glycoprotein H (gH) ectodomain (aa 107–639) which is the membrane-proximal end of the protein in the ?gL-Pass PrV variant of PrV. The antibody contacts residues 332-373 (peripheral helices α6 and α7 of domain III of gH contribute most of the residues that form the epitope recognized by d6.3). PrV is a porcine herpesvirus belonging to the alpha-Herpesvirinae subfamily and is known to cause Aukeszky’s disease in pigs. gH is a type I membrane portein and can interact non-covalently with gL via the large gH ectodomain.

Product Name page	Expected Species Reactivity	Applications
Anti-Glycoprotein H [A13-d6.3]	pseudorabies virus (PrV)	neutralize; crystalize; immunostaining
Anti-Rabies Virus 67kDa protein [EP5G3]	Rabies Virus	WB; NTRL; IP; ELISA
Anti-Rabies Virus 67kDa protein [Fab094]	Rabies Virus	WB; NTRL; ELISA; IP
Anti-Rabies Virus 67kDa protein [GD2D12]	Rabies Virus	WB; NTRL; IP; ELISA

 

Anti-Flavivirus group antigen [D1-4G2-4-15 (4G2)]	Dengue Virus; Zika Virus; West Nile Virus; Flaviviridae	IF; WB; NTRL; ELISA; FC
Anti-Ebola Nucleoprotein [KZ51]	Ebola Virus (Zaire, Ivory Coast, Reston, Sudan)	ELISA; WB; IP; IF
Anti-E2 A domain [F5]	Human Venezuelan Equine Encephalitis Virus	NTRL; crystallization
Anti-E-protein DIII (C-C’) [ZV-64]	Zika Virus	NTRL; crystallization; SPR; FC
Anti-dsRNA [10G1]	Virus	ELISA; IHC; WB
Anti-DIII domain of Dengue E protein [DV10]	Dengue Virus	ELISA; NTRL
Anti-DIII domain of Dengue E protein (DENV-1 and DENV-3) [DV63]	Dengue Virus	ELISA; NTRL
Anti-DI/DII domain of Dengue E protein [DV18]	Dengue Virus	ELISA; NTRL
Anti-CytomegaloVirus (CMV) gH glycoprotein [MSL-109]	CMV	NTRL
Anti-CPV capsid [14]	canine parovirus (CPV)	neutralize; crystallize; cryoEM
Anti-CMV glycoprotein gB [HCMV37]	CMV	NTRL; ELISA; IHC-Fr; IF; ICC
Anti-A14 [BB5.2]	Vaccinia virus	WB; IP; IF