Fc Silent™ Antibodies: Turning down the background noise

Fc Silent| 抗體 | 只要訊號不要雜訊 (Engineered Fc Domain)

Absoluted Antibody 提供一系列抗體商品，其中Fc Silent™ Antibodies系列；能有效降低非特異性Fc結合。Fc Silent™技術，為應用生物工程技術，將Fc receptors (FcγR, FcR)點突變，進而中止抗體與ADCC的功能；有效降低Fc所造成的背景訊號。Fc Silent™抗體應用於免疫細胞時flow cytometry、immunohistochemistry (IHC)資料顯示，有效降低非特異性之Fc結合，所造成的背景值。(訂購抗體前，請確認選擇抗體是否有Fc Silent™修飾標誌)

Anti-DNA/RNA G-quadruplex (and related small molecules) [BG4] 抗體 | 產品描述: 貨號Ab00174-1.1

Recombinant monoclonal antibody to DNA/RNA G-quadruplex (and related small molecules). Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the phage display derived scfv BG4.

抗體名稱	Anti-DNA/RNA G-quadruplex (and related small molecules) [BG4]
抗體貨號	Ab00174-1.1	特異性Specificity: Binds with high selectivity and low nanomolar affinity to DNA and RNA G-quadruplex structures.
免疫原	Immunogen: DNA/RNA G-quadruplex.
應用注意	Application Notes: This antibody has been shown (by ELISA) to bind selectively to G-quadruplex forming DNA and RNA structures. Please note that unlike the original scFv reported by Biffi et al. , this antibody does not have FLAG-tag.
其它相關連結	Biffi G, Tannahill D, McCafferty J, Balasubramanian S. Quantitative visualization of DNA G-quadruplex structures in human cells. Nat Chem. 2013 Mar;5(3):182-6 PMID:23422559 pAbmAbs

 

Product	Expected Species Reactivity	Isotype/Format	Modification
Ab00174-1.1 Anti-DNA/RNA G-quadruplex (and related small molecules) [BG4]	Human	Mouse IgG1
Ab00174-10.6 Anti-DNA/RNA G-quadruplex (and related small molecules) [BG4]	Human	Human Fab fragment	His-Tagged
Ab00174-24.1 Anti-DNA/RNA G-quadruplex (and related small molecules) [BG4]	Human	Goat IgG
Ab00174-1.6 Anti-DNA/RNA G-quadruplex (and related small molecules) [BG4]	Human	Mouse Fab fragment	His-Tagged