Glycolysis Inhibitors抑制劑 | 3-Bromopyruvic acid抑制劑 | Biovision貨號B1045-1000

Glycolysis Inhibitors A hexokinase inhibitor that has been shown to abolish ATP production and cause severe depletion of cellular ATP.

Glycolysis Inhibitors系列商品介紹:

所有癌症和腫瘤的特性，為上調糖酵解作用增加葡萄糖消耗，代謝途徑產生ATP。這種現象被稱為瓦氏（Warburg’s effect）；亦是惡性期間代謝改變的一個重要過程。許多生化和分子生物學研究已經提出了這個機制的改變，包括線粒體缺陷和故障，以適應缺氧腫瘤微環境；致癌信號和代謝酶的異常表達等。最重要的是癌細胞於代謝上，對糖酵解途徑產生的ATP具有依賴性。許多小分子已經出現顯示有希望抗癌活性，作為與其他治療形式組合之單一藥劑。糖酵解抑制劑，因此作為抗癌藥物的發展必將具有廣闊的治療應用，也可朝向與常規藥物和放射治療的細胞抗性相關的惡性腫瘤的目標。

Glycolysis Inhibitors抑制劑 | 3-Bromopyruvic acid抑制劑3-溴丙酮酸(3-Bromopyruvic acid)顯示中止ATP產生，並導致細胞ATP的嚴重消耗，是一個己糖激酶抑制劑(hexokinase inhibitor)。顯示對癌細胞具有在缺氧環境線粒體呼吸缺陷和細胞的強細胞毒活性。3-Bromopyruvic acid is a hexokinase inhibitor that has been shown to abolish ATP production and cause severe depletion of cellular ATP. It displays potent cytotoxic activity against cancer cells with mitochondrial respiratory defects and cells in hypoxic environment

Molecular Formula: C₃H₃BrO₃

Molecular Weight: 166.96

Purity: ≥97% by titration

Solubility: H2O (>100 mg/ml) or DMSO

Catalog #	Product Name+	Size
B1048-100	2-Deoxy-D-Glucose	100 mg
B1048-500	2-Deoxy-D-Glucose	500 mg
B1045-100	3-Bromopyruvic acid	100 mg
B1045-500	3-Bromopyruvic acid	500 mg
B1045-1000	3-Bromopyruvic acid	1 g
B1047-100	6-Aminonicotinamide	100 mg
B1047-500	6-Aminonicotinamide	500 mg
B1058-10	Lonidamine	10 mg
B1058-50	Lonidamine	50 mg
B1046-100	Oxythiamine Chloride Hydrochloride	100 mg
B1046-500	Oxythiamine Chloride Hydrochloride	500 mg
B1046-1000	Oxythiamine Chloride Hydrochloride	1 g
B1056-10	Shikonin	10 mg
B1056-50	Shikonin	50 mg