2-Deoxy-D-Glucose抑制劑 | Biovision貨號: B1048-500

Glycolysis Inhibitors A competitive inhibitor of glucose metabolism.

Glycolysis Inhibitors系列商品介紹:

所有癌症和腫瘤的特性，為上調糖酵解作用增加葡萄糖消耗，代謝途徑產生ATP。這種現象被稱為瓦氏（Warburg’s effect）；亦是惡性期間代謝改變的一個重要過程。許多生化和分子生物學研究已經提出了這個機制的改變，包括線粒體缺陷和故障，以適應缺氧腫瘤微環境；致癌信號和代謝酶的異常表達等。最重要的是癌細胞於代謝上，對糖酵解途徑產生的ATP具有依賴性。許多小分子已經出現顯示有希望抗癌活性，作為與其他治療形式組合之單一藥劑。糖酵解抑制劑，因此作為抗癌藥物的發展必將具有廣闊的治療應用，也可朝向與常規藥物和放射治療的細胞抗性相關的惡性腫瘤的目標。

Glycolysis Inhibitors抑制劑 | 2-Deoxy-D-Glucose抑制劑2-Deoxy-D-Glucose is a glucose analog that has long been known to act as a competitive inhibitor of glucose metabolism. Upon transport into the cells, 2-DG is phosphorylated by hexokinase to 2-DG-P. However, unlike G-6-P, 2-DG-P cannot be further metabolized by phosphohexose isomerase, which converts G-6-P to fructose-6-phosphate . 2-Deoxyglucose-P is trapped and accumulated in the cells, leading to inhibition of glycolysis mainly at the step of phosphorylation of glucose by hexokinase. Inhibition of this rate-limiting step by 2-DG causes a depletion of cellular ATP, leading to blockage of cell cycle progression and cell death in vitro.

 

Molecular Formula: C₆H₁₂O₅

Molecular Weight: 164.16

Purity: ≥98% GC

Solubility: H2O (>15 mg/ml) or DMSO (>15 mg/ml)

Catalog #	Product Name+	Size
B1048-100	2-Deoxy-D-Glucose	100 mg
B1048-500	2-Deoxy-D-Glucose	500 mg
B1045-100	3-Bromopyruvic acid	100 mg
B1045-500	3-Bromopyruvic acid	500 mg
B1045-1000	3-Bromopyruvic acid	1 g
B1047-100	6-Aminonicotinamide	100 mg
B1047-500	6-Aminonicotinamide	500 mg
B1058-10	Lonidamine	10 mg
B1058-50	Lonidamine	50 mg
B1046-100	Oxythiamine Chloride Hydrochloride	100 mg
B1046-500	Oxythiamine Chloride Hydrochloride	500 mg
B1046-1000	Oxythiamine Chloride Hydrochloride	1 g
B1056-10	Shikonin	10 mg
B1056-50	Shikonin	50 mg