Anti-Neurofilament NF-H Antibody 單株抗體 | 貨號Y030095

Product Name Anti-Neurofilament NF-H AntibodyApplication      WB,ICC/IF    Raised In mouse

Specificity        The antibody recognizes NF-H strongly in all mammals tested to date and also in chicken.

Immunogen     Neurofilaments are the 10nm or intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. NF-H is the neurofilament high or heavy molecular weight polypeptide and runs on SDS-PAGE gels at 200-220 kDa, with some variability across species boundaries. Antibodies to NF-H are useful for identifying neuronal cells and their processes in tissue sections and in tissue culture. NF-H antibodies can also be useful in the diagnostics of neurofilament accumulations seen in many neurological diseases, such as Amyotrophic Lateral Sclerosis (also known as Lou Gehrig’s disease) and Alzheimer’s disease. MCA-AH1 is one of numerous antibodies which reacts preferentially with the axonal phosphorylated forms of NF-H. Interestingly these phosphorylated forms of NF-H are normally restricted to axons, while less phosphorylated forms are found in dendrites. However in numerous damage and disease states, phosphorylated NF-H can be detected with MCA-AH1 in dendritic and perikaryal neurofilaments.

Anti-Neurofilament NF-H Antibody | Applied Biological Materials Inc.