CD109  重組蛋白 | T/B cell surface proteins BioWorld貨號NCP0172

CD109 是糖基磷脂醯肌醇 (glycosylphosphatidylinositol,GPI) 連接的糖蛋白(glycoprotein )，屬於含硫酯蛋白的 alpha2-巨球蛋白家族(alpha2-macroglobulin family)。 CD109 與 TGF-β 受體 I (TGF-beta receptor I, TbRI) 相關並抑制 TGF-β 信號傳導。 CD109 在其弗林蛋白酶切割位點(Furin cleavage site )的切割導致釋放其大的氨基末端結構域(amino-terminal domain)，然後該結構域與 TGF-β 受體 I (TGF-beta receptor I)結合以抑制 TGF-β 信號傳導(TGF-beta signaling)。 CD109 在 CD34+ 骨髓細胞(bone marrow cells)和間充質幹細胞(mesenchymal stem cells)、活化的血小板( activated platelets)、活化的 T 細胞(activated T cells)、內皮細胞和多種腫瘤的子集上表達。升高的 CD109(Elevated CD109 expression) 表達被認為是幾種癌症的診斷/預後標誌物。

https://bioworlde.com/

 

Product Name	CD109 Recombinant Protein
Catalog No.	NCP0172
Swiss-Prot	Q6YHK3
Host	E.coli
Tag	His-tag in C-terminal
Restriction sites	NdeI-XhoI
Background
Soluble	PBS, 4M Urea, PH7.4
Purification&Purity	Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE).
Concentration	≥0.5mg/ml

Restriction sites :
NdeI-XhoI

Background :
CD109 is a glycosylphosphatidylinositol (GPI)-linked glycoprotein that belongs to the alpha2-macroglobulin family of thioester containing proteins. CD109 is associated with TGF-beta receptor I (TbRI) and inhibits TGF-beta signaling. Cleavage of CD109 at its Furin cleavage site results in the release of its large amino-terminal domain, which then binds to the TGF-beta receptor I to inhibit TGF-beta signaling. CD109 is expressed on a subset of CD34+ bone marrow cells and mesenchymal stem cells, activated platelets, activated T cells, endothelial cells, and a wide variety of tumors. Elevated CD109 expression has been considered a diagnostic/prognostic marker for several types of cancers.

Soluble :
PBS, 4M Urea, PH7.4

Purification&Purity :
Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE).

Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Expression vector :
pet-22b(+)

BiowMW :
~36kDa

Note :
For research use only, not for use in diagnostic procedure.

concentration :
≥0.5mg/ml