CD105 重組蛋白 | T/B cell surface proteins BioWorld貨號NCP0171

CD105/Endoglin 是 TGF-β 受體複合物( TGF-β receptor complex)的輔助受體(auxiliary receptor )，在相關信號通路( signaling pathway)中發揮作用。 CD105/內皮糖蛋白(CD105/Endoglin)是一種跨膜蛋白( transmembrane protein )，以二硫鍵連接(disulfide-linked homodimer)的同二聚體形式存在。它主要表達於血管和結締組織以及內皮細胞和基質細胞。據報導，在傷口癒合(wound healing )和腫瘤血管形成(tumor vascularization)過程中，以及在炎症組織(inflammatory tissues)和發育中的胚胎( developing embryos)中， CD105/內皮糖蛋白(CD105/Endoglin)表達上調。已發現 CD105/內皮糖蛋白(CD105/Endoglin)的突變是遺傳性出血性毛細血管擴張症 (hereditary hemorrhagic telangiectasia, HHT) 的致病因素，遺傳性出血性毛細血管擴張症 (hereditary hemorrhagic telangiectasia, HHT) 是一種以血管結構畸形為特徵的疾病。這種蛋白質對正常和腫瘤血管功能(tumor vascular function)的重要性使其成為內皮細胞增殖(endothelial cell proliferatio)的良好標誌物以及癌症的潛在治療靶點。

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Product Name	CD105 Recombinant Protein
Catalog No.	NCP0171
Swiss-Prot	P17813
Host	E.coli
Tag	His-tag in C-terminal
Restriction sites	NdeI-XhoI
Background
Soluble	PBS, 4M Urea, PH7.4
Purification&Purity	Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE).
Concentration	≥0.5mg/ml

Expression vector :
pet-22b(+)

BiowMW :
~62kDa

Soluble :
PBS, 4M Urea, PH7.4

Purification&Purity :
Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE).

Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Restriction sites :
NdeI-XhoI