Anti-BLC2 [bcl-2/124]抗體 | Anti-BLC2 [bcl-2/124], Mouse IgG1, Kappa貨號Ab01322-1.1   

抗體介紹: 該抗體識別人BLC-2，它是多種細胞類型中的抗凋亡因子。它的失調牽涉到不同的狀況，例如癌症和自身免疫性疾病。此抗體可應用於Blocking, ELISA, FC等實驗。

Alternative Name(s) of Target: Apoptosis regulator Bcl-2; AW986256; B-cell CLL/lymphoma 2; Bcl-2; C430015F12Rik; D630044D05Rik; D830018M01Rik; protein phosphatase 1; regulatory subunit 50; bcl-2-124; bcl2/124

免疫原(Immunogen): This antibody was raised against a synthetic peptide of amino acids 41-54 of human bcl-2 oncoprotein.

Clone Name: 1B4。Published Application(s): Blocking, ELISA, FC

Alternative Name(s) of Target: Apoptosis regulator Bcl-2; AW986256; B-cell CLL/lymphoma 2; Bcl-2; C430015F12Rik; D630044D05Rik; D830018M01Rik; protein phosphatase 1; regulatory subunit 50; bcl-2-124; bcl2/124

Immunogen: This antibody was raised against a synthetic peptide of amino acids 41-54 of human bcl-2 oncoprotein.

Specificity: This antibody recognises human BLC-2 which is an antiapoptotic factor in various cell types. Its disregulation was implicated in different conditions, such as cancers and autoimmune disorders.

Application Notes: This antibody has been used extensively in attempts aimed at characterising various cancer tissues via immunohistochemical staining. One group used bcl-2-124 antibody to label large B-cell lymphoma samples for bcl2 in order to perform its immunophenotypic and genetic depiction (Chang et al., 2016). Another group took advantage of this antibody while analysing the molecular picture of a case of the cystic synovial sarcoma of the pleura where they observed positive immunohistochemical staining in tumor cells (Tajima et al., 2015). Bcl-2 plays an important role as an inhibitor of apoptosis and its identification is often useful while analysing various factors influencing apoptosis. For instance, bcl-2/124 antibody has been successfully utilised in such experiments identifying bcl-2 via Western blot – Gomez-Bougie (2007) probed the influence of bortezomib on HMCL cells and detected bcl-2 signal on Western blots.

Antibody first published in: Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation. Am J Pathol. 1990 Aug;137(2):225-32. PMID:2201196 Note on publication: This article describes generation and characterisation of the bcl-2/124 antibody.

Purified antibody.

Purification: Protein A affinity purified

Supplied in: PBS with 0.02% Proclin 300.

Storage Recommendation: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.

Concentration: 1 mg/ml.

產品貨號	Mouse target	抗體clone	Original Antibody format
Ab01052	4-1BB (CD137)	LOB12.3	Rat IgG1
Ab01054	4-1BBL (CD137L)	AT113-2	Rat IgG1
Ab00881	4-1BBL (CD137L)	TKS-1	Rat IgG2a
Ab01027	BTLA	HMBT-6B2	Hamster IgG
Ab00670	CD27	LG.3A10	Hamster IgG
Ab00895	CD27	RM27-3E5	Rat IgG2a
Ab00286	CD28	E18	Mouse IgG2b
Ab00285	CD28	D665	Mouse IgG1
Ab01109	CD40	3/23	Rat IgG2a
Ab01087	CD40L (CD154)	MR1	Hamster IgG
Ab00816	CD70	TAN 1-7	Rat IgG2a
Ab01056	CD70	TAN1-6	Rat IgG2a
Ab01028	CD80 (B7-1)	RM80	Rat IgG2a
Ab01029	CD86 (B7-2)	PO.3	Rat IgG2b
Ab01089	CD153	RM153	Rat IgG2b
Ab01297	CD96	6A6	Rat IgG2a
Ab00894	CTLA-4	9H10	Hamster IgG2
Ab01018	CTLA-4	9D9	Mouse IgG2b
Ab01088	GAL-9	RG9-35	Rat IgG2a
Ab01060	GITR	DTA-1	Rat IgG2a
Ab00374	GITR	YGITR 860.103.5	Rat IgG2b
Ab00631	GITR	YGITR765	Rat IgG2b
Ab00630	GITRL	YGL386	Rat IgG1
Ab01026	HVEM	HMHV-1B18	Hamster IgG
Ab00814	ICOS	7E.17G9	Rat IgG2b
Ab00882	ICOSL	HK5.3	Rat IgG2a
Ab01295	LAG3	C9B7W	Rat IgG1
Ab01295	LAG3	C9B7W	Rat IgG1
Ab00110	OX40 (CD134)	OX86	Rat IgG1
Ab00564	OX40L	OX-89	Rat IgG1
Ab00813	PD-1	RMP1-14	Rat IgG2a
Ab01017	PD-1H (VISTA)	mam82	Mouse IgG1
Ab01016	PD-1H (VISTA)	MH5A	Hamster IgG
Ab00373	PD-L1	YDC 127.1.1	Rat IgG2a
Ab00883	PD-L2	TY25	Rat IgG2a
Ab00875	PDPN (MAP-Tag)	PMab-1	Rat IgG2a
Ab00973	TIGIT	4D4	Hamster IgG
Ab01258	TIGIT	1B4	Mouse IgG1
Ab01032	TIM-1	3B3	Rat IgG2a
Ab01110	TIM-2	RMT2-14	Rat IgG2a
Ab01057	TIM-3	2C12	Rat IgG1
Ab01058	TIM-4	5G3	Rat IgG1
Ab01059	TIM-4	3A1	Rat IgG1