免疫療法研究(Immunotherapy Research) 活體用重組抗體

針對治療研究，抗蛋白質的抗體參與co-stimulation和免疫系統調節(immune cell regulation)。 有些進入臨床階段(clinic)；更多部份仍處於研究階段。免疫細胞信號傳導(immune cell signaling)的許多方面仍然未知，Absolute Antibody開發了針對臨床相關蛋白的重組工程抗體，提供一系列免疫療法研究(Immunotherapy Research) 活體用重組抗體。

• Your favourite research tools, now updated through antibody engineering for improved performance in vivo
• Reduce immunogenicity by matching antibody species to your host organism
• Tailor effector function by choosing from our range of antibody isotypes and subtypes
• Explore new possibilities by combining two of these antibodies into a custom bispecific reagent

TIGIT [1B4] 抗體 | Anti-TIGIT [1B4], Mouse IgG1, Lambda貨號Ab01258-1.1   

抗體介紹:  TIGIT [1B4] 抗體對TIGIT的結合特異性 (Specificity)。已通過ELISA分析(ELISA analysis) 和使用TIGIT和活化的小鼠脾細胞的流式細胞術證實(flow cytometry)（Dixon等，2018）。 TIGIT抗體具有特異性染色活化的原代野生型T細胞 (primary wild-type T cells)（Dixon等，2018）。 TIGIT抗體完全阻斷CD155與TIGIT的結合，並在體內充當TIGIT阻斷抗體(blocking antibody)。Administration of this antibody increases experimental autoimmune encephalomyelitis (EAE) severity，並確定已建立的MC38結腸癌(colon carcinoma)和GL261膠質母細胞瘤生長（Dixon等，2018）。 該抗體與抗PD-1阻斷抗體協同作用，以在結腸癌模型中實現完全tumour regression（Dixon等，2018）。 原始小鼠IgG1抗體在體內不耗盡TIGIT表達的CD4 +或CD8 + T細胞，也不影響體外T細胞增殖（Dixon等，2018）。此抗體可應用於Blocking, ELISA, FC等實驗。Alternative Name(s) of Target: Ig細胞和ITIM結構域; 具有Ig和ITIM結構域的T細胞免疫受體; V-set和含跨膜結構域的蛋白3; VSTM3免疫原(Immunogen: 通過用鼠重組TIGIT四聚體免疫TIGIT  –  /  – 小鼠來產生該抗體。

Antibody first published in: Dixon et al. Functional Anti-TIGIT Antibodies Regulate Development of Autoimmunity and Antitumor Immunity J Immunol. 2018 Apr 15;200(8):3000-3007 PMID:29500245

UniProt Accession Number of Target Protein: P86176

產品貨號	Mouse target	抗體clone	Original Antibody format
Ab01052	4-1BB (CD137)	LOB12.3	Rat IgG1
Ab01054	4-1BBL (CD137L)	AT113-2	Rat IgG1
Ab00881	4-1BBL (CD137L)	TKS-1	Rat IgG2a
Ab01027	BTLA	HMBT-6B2	Hamster IgG
Ab00670	CD27	LG.3A10	Hamster IgG
Ab00895	CD27	RM27-3E5	Rat IgG2a
Ab00286	CD28	E18	Mouse IgG2b
Ab00285	CD28	D665	Mouse IgG1
Ab01109	CD40	3/23	Rat IgG2a
Ab01087	CD40L (CD154)	MR1	Hamster IgG
Ab00816	CD70	TAN 1-7	Rat IgG2a
Ab01056	CD70	TAN1-6	Rat IgG2a
Ab01028	CD80 (B7-1)	RM80	Rat IgG2a
Ab01029	CD86 (B7-2)	PO.3	Rat IgG2b
Ab01089	CD153	RM153	Rat IgG2b
Ab01297	CD96	6A6	Rat IgG2a
Ab00894	CTLA-4	9H10	Hamster IgG2
Ab01018	CTLA-4	9D9	Mouse IgG2b
Ab01088	GAL-9	RG9-35	Rat IgG2a
Ab01060	GITR	DTA-1	Rat IgG2a
Ab00374	GITR	YGITR 860.103.5	Rat IgG2b
Ab00631	GITR	YGITR765	Rat IgG2b
Ab00630	GITRL	YGL386	Rat IgG1
Ab01026	HVEM	HMHV-1B18	Hamster IgG
Ab00814	ICOS	7E.17G9	Rat IgG2b
Ab00882	ICOSL	HK5.3	Rat IgG2a
Ab01295	LAG3	C9B7W	Rat IgG1
Ab01295	LAG3	C9B7W	Rat IgG1
Ab00110	OX40 (CD134)	OX86	Rat IgG1
Ab00564	OX40L	OX-89	Rat IgG1
Ab00813	PD-1	RMP1-14	Rat IgG2a
Ab01017	PD-1H (VISTA)	mam82	Mouse IgG1
Ab01016	PD-1H (VISTA)	MH5A	Hamster IgG
Ab00373	PD-L1	YDC 127.1.1	Rat IgG2a
Ab00883	PD-L2	TY25	Rat IgG2a
Ab00875	PDPN (MAP-Tag)	PMab-1	Rat IgG2a
Ab00973	TIGIT	4D4	Hamster IgG
Ab01258	TIGIT	1B4	Mouse IgG1
Ab01032	TIM-1	3B3	Rat IgG2a
Ab01110	TIM-2	RMT2-14	Rat IgG2a
Ab01057	TIM-3	2C12	Rat IgG1
Ab01058	TIM-4	5G3	Rat IgG1
Ab01059	TIM-4	3A1	Rat IgG1