{"id":9804,"date":"2017-04-28T20:32:30","date_gmt":"2017-04-28T12:32:30","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=9804"},"modified":"2022-07-22T12:00:30","modified_gmt":"2022-07-22T04:00:30","slug":"z-4-hydroxytamoxifen-4-%e7%be%a5%e5%9f%ba%e4%bb%96%e8%8e%ab%e6%98%94%e8%8a%ac%ef%bd%9c%e8%b2%a8%e8%99%9fb1114-25","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=9804","title":{"rendered":"(Z)-4-Hydroxytamoxifen -4-\u7fa5\u57fa\u4ed6\u83ab\u6614\u82ac\uff5c\u8ca8\u865fB1114-25"},"content":{"rendered":"

\u5546\u54c1<\/strong>: <\/strong>(Z)-4-Hydroxytamoxifen\uff5c\u8ca8\u865fB1114-25<\/p>\n

A potent estrogen receptor antagonist and Cas9 activator<\/p>\n

\u7522\u54c1\u4ecb\u7d39<\/strong>:<\/strong> (Z)-4-Hydroxytamoxifen\uff08Z\uff09-4-\u7fa5\u57fa\u4ed6\u83ab\u6614\u82ac\u662fTamoxifen\u4ed6\u83ab\u6614\u82ac\u7684\u4ee3\u8b1d\u7269\uff08BIOVISION\u8ca8\u865f\uff031551\uff09; \u4f5c\u70ba\u6709\u6548\u7684\u96cc\u6fc0\u7d20\u53d7\u9ad4\u62ee\u6297\u5291\u3002 \u986f\u793a\u51fa\u6bd4parent compound\u5316\u5408\u7269\u66f4\u591a\u7684\u6548\u529b\u3002\u6fc0\u6d3b\u5167\u542b\u80bd\u9023\u63a5\u7684\u7121\u6d3b\u6027Cas9\uff0c\u6e1b\u5c11off-target\u975e\u9776\u6a19CRISPR\u4ecb\u5c0e\u7684\u57fa\u56e0\u7de8\u8f2f\u3002<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Alternate Name<\/td>\n4-[(1Z)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol; 4-OH-TAM<\/td>\n<\/tr>\n
Appearance<\/td>\nWhite solid<\/td>\n<\/tr>\n
CAS #<\/td>\n68047-06-3<\/td>\n<\/tr>\n
Molecular Formula<\/td>\nC\u2082\u2086H\u2082\u2089NO\u2082<\/td>\n<\/tr>\n
Molecular Weight<\/td>\n387.51<\/td>\n<\/tr>\n
Purity<\/td>\n\u226598% by HPLC<\/td>\n<\/tr>\n
Solubility<\/td>\nDMSO (>35 mg\/ml) or H2O (>10 mg\/ml)<\/td>\n<\/tr>\n
SMILES<\/td>\nCCC(=C(C1=CC=C(C=C1)O)C2=CC=C(C=C2)OCCN(C)C)C3=CC=CC=C3<\/td>\n<\/tr>\n
InChi<\/td>\nInChI=1S\/C26H29NO2\/c1-4-25(20-8-6-5-7-9-20)26(21-10-14-23(28)15-11-21)22-12-16-24(17-13-22)29-19-18-27(2)3\/h5-17,28H,4,18-19H2,1-3H3\/b26-25-<\/td>\n<\/tr>\n
InChi Key<\/td>\nTXUZVZSFRXZGTL-QPLCGJKRSA-N<\/td>\n<\/tr>\n
PubChem CID<\/td>\n449459<\/a><\/td>\n<\/tr>\n
MDL Number<\/td>\nMFCD00278780<\/td>\n<\/tr>\n
Handling<\/td>\nProtect from air and light<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u5176\u5b83\u5546\u54c1<\/strong>:\u00a0<\/strong> \u81bd\u56fa\u9187\u6392\u51fa\u87a2\u5149\u5206\u6790\u5957\u7d44<\/a> | CETP\u81bd\u56fa\u9187\u916f\u8f49\u904b\u86cb\u767dELISA<\/a> | Irisin\u7af6\u722d\u578bELISA<\/a> | Free Fatty Acid\u5448\u8272\u87a2\u5149\u5206\u6790<\/a> | Triglyceride\u4e09\u9178\u7518\u6cb9\u916f\u5b9a\u91cf\u5206\u6790<\/a> \u3010\u67d3\u8272\u5546\u54c1\u3011<\/strong> Lipid\u8102\u8cea\u67d3\u8272\u5957\u7d44<\/a> | \u81bd\u56fa\u9187\u67d3\u8272\u5957\u7d44<\/a> \u3010\u8403\u53d6\u5546\u54c1\u3011<\/strong>\u8102\u80aa\u7d44\u7e54\u86cb\u767d\u8cea\u8403\u53d6<\/a><\/p>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

\u5546\u54c1: (Z)-4-Hydroxytamoxifen\uff5c\u8ca8\u865fB1114-25 A potent estrogen […]<\/p>\n","protected":false},"author":3,"featured_media":9805,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[486],"tags":[3766],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/9804"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=9804"}],"version-history":[{"count":1,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/9804\/revisions"}],"predecessor-version":[{"id":9806,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/9804\/revisions\/9806"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/9805"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=9804"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=9804"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=9804"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}