{"id":9386,"date":"2017-04-12T12:10:04","date_gmt":"2017-04-12T04:10:04","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=9386"},"modified":"2022-07-22T14:58:05","modified_gmt":"2022-07-22T06:58:05","slug":"9386","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=9386","title":{"rendered":"CYP2D6\u6291\u5236\u5feb\u7be9\u5206\u6790\u5957\u7d44 | Biovision\u8ca8\u865fK704"},"content":{"rendered":"<p><span style=\"color: #ff6600;\"><a style=\"color: #ff6600;\" href=\"http:\/\/biopioneer.com.tw\/?p=9386\" target=\"_blank\"><strong>Cytochrome P450 2D6 (CYP2D6) <\/strong><strong>\u6291\u5236\u5feb\u7be9<\/strong> <strong>(Fluorometric)<\/strong>\u87a2\u5149\u5206\u6790\u5957\u7d44 | <strong>\u8ca8\u865f<\/strong><strong>K704-200<\/strong><\/a><\/span><\/p>\n<p><strong><em>High-throughput compatible, quick and easy screening for CYP2D6 inhibitors or ligands; Includes human CYP2D6 &#8211; NADPH Reductase.<\/em><\/strong><\/p>\n<p><strong>\u7522\u54c1\u4ecb\u7d39<\/strong><strong>\uff1a<\/strong>\u7d30\u80de\u8272\u7d20P450 2D6\uff08CYP2D6\uff0cEC 1.14.14.1\uff09\u662f\u5fae\u7c92\u9ad4\u7570\u7a2e\u751f\u7269\u4ee3\u8b1d\u9176\u7684\u7d30\u80de\u8272\u7d20P450\u55ae\u6c27\u5316\u9176\uff08CYP\uff09\u5bb6\u65cf\u7684\u6210\u54e1\u3002 CYP\u662f\u8ca0\u8cacI\u671f\u751f\u7269\u8f49\u5316\u53cd\u61c9\u7684\u819c\u7d50\u5408\u7684\u8840\u6e05\u86cb\u767d\uff0c\u5176\u4e2d\u89aa\u8102\u6027\u85e5\u7269\u548c\u5176\u4ed6\u7570\u751f\u7269\u5316\u5408\u7269\u8f49\u5316\u70ba\u66f4\u89aa\u6c34\u7684\u7522\u7269\u4ee5\u4fc3\u9032\u9ad4\u5167\u6392\u6cc4\u3002 CYP2D6\u7528\u82b3\u74b0\u548c\u6c2e\u539f\u5b50\u50ac\u5316\u89aa\u8102\u6027\u9e7c\u7684\u6c27\u5316\uff0c\u4e26\u5728\u809d\u548c\u8166\u7d44\u7e54\u4e2d\u9ad8\u5ea6\u8868\u9054\u3002\u8a72\u9176\u8ca0\u8cac\u4eba\u985e\u901a\u5e38\u4f7f\u7528\u7684\u6240\u6709\u5c0f\u5206\u5b50\u85e5\u7269\u7684\u8fd125\uff05\u7684\u4ee3\u8b1d\uff0c\u7279\u5225\u662f\u7cbe\u795e\u85e5\u7269\uff0c\u5982\u6297\u6291\u9b31\u85e5\uff0c\u6297\u7cbe\u795e\u75c5\u85e5\u548c\u8208\u596e\u5291\u3002 CYP2D6\u57fa\u56e0\u5728\u4eba\u7fa4\u4e2d\u662f\u9ad8\u5ea6\u591a\u614b\u7684\uff0c\u6839\u64da\u7b49\u4f4d\u57fa\u56e0\u8b8a\u7570\u548c\u57fa\u56e0\u62f7\u8c9d\u6578\uff0c\u6240\u5f97\u5230\u7684CYP2D6\u6d3b\u6027\u5f9e\u5b8c\u5168\u4ee3\u8b1d\u7f3a\u9677\u5230\u8d85\u5feb\u901f\u4ee3\u8b1d\u3002\u7531\u65bc\u9019\u7a2e\u5ee3\u6cdb\u7684\u8868\u578b\u8b8a\u7570\u6027\uff0cCYP2D6\u7d93\u5e38\u6d89\u53ca\u85e5\u7269\u6bd2\u6027\u548c\u81e8\u5e8a\u85e5\u7269\/\u85e5\u7269\u76f8\u4e92\u4f5c\u7528\u3002\u6b64\u5916\uff0c\u5c0d\u65bc\u85e5\u7269\u6d3b\u6027\u9700\u8981\u7531\u524d\u85e5\u5f62\u5f0f\u4ee3\u8b1d\u7684\u85e5\u7269\uff0cCYP2D6\u6291\u5236\u6216\u7b49\u4f4d\u57fa\u56e0\u7f3a\u9677\u53ef\u5c0e\u81f4\u85e5\u7269\u529f\u6548\u964d\u4f4e\u3002<\/p>\n<p><img decoding=\"async\" src=\"http:\/\/www.biovision.com\/media\/catalog\/product\/cache\/1\/image\/650x\/040ec09b1e35df139433887a97daa66f\/k\/7\/k704.jpg\" alt=\"\" \/><\/p>\n<p><strong>\u7522\u54c1\u898f\u683c<\/strong><strong>:<\/strong> \u6b64\u5916\uff0c\u5c0d\u65bc\u85e5\u7269\u6d3b\u6027\u9700\u8981\u7531\u524d\u85e5\u5f62\u5f0f\u4ee3\u8b1d\u7684\u85e5\u7269\uff0cCYP2D6\u6291\u5236\u6216\u7b49\u4f4d\u57fa\u56e0\u7f3a\u9677\u53ef\u5c0e\u81f4\u85e5\u7269\u529f\u6548\u964d\u4f4e\u3002 BioVision\u7684CYP2D6\u6291\u5236\u5291\u7be9\u9078\u8a66\u5291\u76d2\u53ef\u4ee5\u5728\u53ef\u9760\u7684\u9ad8\u901a\u91cf\u87a2\u5149\u6e2c\u5b9a\u4e2d\uff0c\u5feb\u901f\u7be9\u9078\u5316\u5408\u7269CYP2D6\u76f8\u4e92\u4f5c\u7528\u7684\u85e5\u7269\u548c\u5176\u4ed6\u65b0\u5316\u5b78\u7269\u8cea\uff08NCE\uff09\u3002\u8a72\u8a66\u5291\u76d2\u63d0\u4f9b\u4ebaCYP2D6\u548c\u7d30\u80de\u8272\u7d20P450\u9084\u539f\u9176\uff08CPR\uff09\u9176\u7684\u9175\u6bcd\u5fae\u7c92\u9ad4\u88fd\u5291\u3002\u8a72\u6e2c\u5b9a\u4f7f\u7528\u975e\u87a2\u5149CYP2D6\u9078\u64c7\u6027\u5e95\u7269\uff0c\u5176\u8f49\u5316\u70ba\u5728\u53ef\u898b\u5149\u7bc4\u570d\uff08Ex \/ Em = 390 \/ 468nm\uff09\u4e2d\u6aa2\u6e2c\u5230\u7684\u9ad8\u5ea6\u87a2\u5149\u4ee3\u8b1d\u7269\uff0c\u78ba\u4fdd\u9ad8\u7684\u4fe1\u865f\u8207\u80cc\u666f\u6bd4\uff0c\u5e7e\u4e4e\u4e0d\u53d7\u81ea\u767c\u87a2\u5149\u7684\u5e72\u64fe\u3002\u8a72\u8a66\u5291\u76d2\u5305\u542b\u4e00\u5957\u5b8c\u6574\u7684\u8a66\u5291\uff0c\u8db3\u4ee5\u572896\u5b54\u677f\u4e2d\u9032\u884c200\u6b21\u53cd\u61c9\u3002<\/p>\n<table width=\"838\">\n<tbody>\n<tr>\n<td><strong>Size<\/strong><\/td>\n<td>200 assays<\/td>\n<\/tr>\n<tr>\n<td><strong>SKU+Size<\/strong><\/td>\n<td>K704-200<\/td>\n<\/tr>\n<tr>\n<td><strong>Detection Method<\/strong><\/td>\n<td>Fluorescence (Ex\/Em 390\/468 nm)<\/td>\n<\/tr>\n<tr>\n<td><strong>Species Reactivity<\/strong><\/td>\n<td>Eukaryotes<\/td>\n<\/tr>\n<tr>\n<td><strong>Applications<\/strong><\/td>\n<td>Rapid, high-throughput screening of drugs and novel ligands.<br \/>\nDevelopment of structure-activity relationship (SAR) models to predict CYP2D6 inhibition liability of novel compounds.<br \/>\nPrediction of adverse drug-drug interaction potential and bioavailability for compounds metabolized by CYP2D6.<\/td>\n<\/tr>\n<tr>\n<td><strong>Features &amp; Benefits<\/strong><\/td>\n<td>\u2022 Simple, highly sensitive, high-throughput compatible<br \/>\n\u2022 Rapid screening of CYP2D6 inhibitors or ligands<br \/>\n\u2022 Kit includes the canonical CYP2D6 inhibitor Quinidine and a stable, recombinant human CYP2D6 co-expressed with NADPH Reductase<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cytochrome P450 2D6 (CYP2D6) \u6291\u5236\u5feb\u7be9 (Fluorometric)\u87a2\u5149\u5206\u6790\u5957\u7d44  [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":8690,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[498],"tags":[3855],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/9386"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=9386"}],"version-history":[{"count":3,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/9386\/revisions"}],"predecessor-version":[{"id":13477,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/9386\/revisions\/13477"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/8690"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=9386"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=9386"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=9386"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}