{"id":54921,"date":"2026-07-06T12:43:12","date_gmt":"2026-07-06T04:43:12","guid":{"rendered":"https:\/\/biopioneer.com.tw\/?p=54921"},"modified":"2026-07-06T12:43:12","modified_gmt":"2026-07-06T04:43:12","slug":"laduviglusib%ef%bc%88%e5%8c%96%e5%ad%b8%e5%90%8d%e7%82%ba-chir-99021%ef%bc%89-cas1797989-42-4-selleckchem%e8%b2%a8%e8%99%9fs2924","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=54921","title":{"rendered":"Laduviglusib\uff08\u5316\u5b78\u540d\u70ba CHIR-99021\uff09 \u00a0| CAS#1797989-42-4 Selleckchem\u8ca8\u865fS2924"},"content":{"rendered":"
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Selleckchem \u7cfb\u5217\u5546\u54c1\/ GSK-3\u6291\u5236\u5291>>Laduviglusib\uff08\u5316\u5b78\u540d\u70ba CHIR-99021\uff09\u00a0\u00a0<\/span><\/span><\/span><\/span><\/strong>
\n<\/span><\/span><\/span><\/strong><\/p>\n

\u76ee\u524d Selleckchem \u63d0\u4f9b\u8d85\u904e\u5341\u4e8c\u842c\u7a2e\u6291\u5236\u5291\uff0c\u61c9\u7528\u9818\u57df\u6db5\u84cb Tyrosine Kinase\u3001MAPK\u3001PI3K\/Akt\/mTOR\u3001Nuronal Signaling\u3001Epigenetics\u3001Apoptosis \u7b49\u7d30\u80de\u8a0a\u606f\u50b3\u5c0e\u8def\u5f91\u7814\u7a76\uff1b\u53e6\u6709\u8d85\u904e\u516b\u5343\u7a2e\u751f\u7269\u6d3b\u6027\u5c0f\u5206\u5b50\u6240\u7d44\u6210\u7684\u5404\u5f0f\u5316\u5408\u7269\u5eab\uff0c\u5176\u4e2d\u5305\u542bFDA \u6838\u51c6\u85e5\u7269\uff0c\u53ef\u4f9b\u9032\u884c\u9ad8\u901a\u91cf\u85e5\u7269\u7be9\u9078\u3002\u6bcf\u9805\u7522\u54c1\u4e0d\u50c5\u63d0\u4f9b\u6709\u8a73\u76e1\u7684\u5316\u5b78\u6aa2\u6e2c\u6578\u64da\uff08\u5305\u62ec NMR \u6838\u78c1\u5171\u632f\u548c HPLC \u9a57\u8b49\uff09\uff0c\u4ea6\u5118\u53ef\u80fd\u56ca\u62ec\u6587\u737b\u7d00\u9304\u3001\u7d30\u80de\u5be6\u9a57\u3001\u52d5\u7269\u5be6\u9a57\u3001\u81e8\u5e8a\u8a66\u9a57\u548c\u4f7f\u7528\u8005\u53cd\u994b\u7684\u751f\u7269\u6d3b\u6027\u6578\u64da\u8207\u5716\u8868\u5f71\u50cf\uff08\u5982 Western Blot\u3001IHC\u3001MTT\u3001RT-PCR \uff09\u7b49\u76f8\u95dc\u8cc7\u8a0a\uff0c\u4ee5\u5354\u52a9\u7528\u6236\u66f4\u9f4a\u5168\u4fbf\u5229\u5730\u638c\u63e1\u85e5\u7269\u6838\u5fc3\u8cc7\u8a0a\u3002\u6b61\u8fce\u9ede\u64ca\u4e0b\u65b9\u9023\u7d50\u700f\u89bd\u8a73\u7d30\u7522\u54c1\u8cc7\u8a0a\uff1b\u6216\u8207\u6211\u5011\u806f\u7e6b\uff0c\u6211\u5011\u5c07\u4f9d\u7167\u60a8\u7684\u7814\u7a76\u9700\u6c42\u63d0\u4f9b\u6700\u9069\u5408\u7684\u7522\u54c1\u5efa\u8b70\u8207\u6700\u65b0\u6d3b\u52d5\u8a0a\u606f\u3002>>\u66f4\u591aSelleckchem\u5546\u54c1<\/span><\/strong><\/em><\/span><\/a><\/p>\n

<\/p>\n

Laduviglusib\uff08\u5316\u5b78\u540d\u70ba CHIR-99021\uff09 \u00a0| CAS#1797989-42-4 Selleckchem\u8ca8\u865fS2924<\/a><\/span><\/p>\n

CHIR-99021 (CT99021, CAS 252917-06-9) is a selective inhibitor of glycogen synthase kinase-3 (GSK-3)<\/p>\n

\u7522\u54c1\u4ecb\u7d39<\/span><\/strong><\/span><\/p>\n

Laduviglusib\uff08\u5316\u5b78\u540d\u70ba CHIR-99021\uff09\u662f\u4e00\u7a2e\u5f37\u6548\u4e14\u7279\u7570\u6027\u7684GSK-3\u03b2\u6291\u5236\u5291\u3002\u5b83\u900f\u904e\u6291\u5236GSK-3\u03b2\u4f86\u5f71\u97ffWnt\/\u03b2-catenin\u548cPI3K\/AKT\u8a0a\u865f\u901a\u8def\uff0c\u8a98\u5c0e\u03b2-catenin\u7a4d\u7d2f\uff0c\u9032\u800c\u6709\u6548\u4fc3\u9032\u5e79\u7d30\u80de\u5206\u5316( stem cell differentiation)\u3001\u7d30\u80de\u91cd\u7de8\u7a0b(cellular reprogramming)\u53ca\u589e\u6b96(proliferation)\uff0c\u540c\u6642\u6291\u5236\u7d30\u80de\u51cb\u4ea1( apoptosis)\u548c\u7e96\u7dad\u5316 (fibrosis)\u3002\u5e79\u7d30\u80de\u7814\u7a76\u8207\u518d\u751f\u91ab\u5b78 (Stem Cell Research and Regenerative Medicine)\uff1a<\/span><\/strong>Laduviglusib \u5ee3\u6cdb\u7528\u65bc\u7dad\u6301\u80da\u80ce\u5e79\u7d30\u80de\u548c\u8a98\u5c0e\u591a\u80fd\u5e79\u7d30\u80de\u7684\u591a\u80fd\u6027\u548c\u81ea\u6211\u66f4\u65b0\u80fd\u529b\u3002\u5b83\u900f\u904e\u9078\u64c7\u6027\u6291\u88fd\u7cd6\u539f\u5408\u6210\u9176\u6fc0\u91763\uff08GSK3\uff09\u4f86\u6d3b\u5316\u7d93\u5178\u7684Wnt\u8a0a\u865f\u8def\u5f91\u3002\u9019\u7a2e\u6d3b\u5316\u4f5c\u7528\u53ef\u963b\u6b62\u03b2-catenin\u7684\u964d\u89e3\uff0c\u4f7f\u5176\u79fb\u4f4d\u81f3\u7d30\u80de\u6838\u4e26\u8abf\u63a7\u57fa\u56e0\u8868\u73fe\u3002\u6b64\u5916\uff0c\u5b83\u4e5f\u662f\u591a\u7a2e\u5206\u5316\u65b9\u6848\u7684\u95dc\u9375\u7d44\u6210\u90e8\u5206\uff0c\u80fd\u5920\u5b9a\u5411\u751f\u6210\u7279\u5b9a\u7d30\u80de\u8b5c\u7cfb\uff0c\u4f8b\u5982\u5fc3\u808c\u7d30\u80de\u548c\u795e\u7d93\u7956\u7d30\u80de\uff0c\u4f7f\u5176\u6210\u70ba\u985e\u5668\u5b98\u767c\u80b2\u548c\u518d\u751f\u7642\u6cd5\u4e2d\u4e0d\u53ef\u6216\u7f3a\u7684\u6210\u5206\u3002<\/span>\u816b\u7624\u5b78\u8207\u764c\u75c7\u7814\u7a76 (Oncology and Cancer Research)<\/span><\/strong>\u5728\u816b\u7624\u5b78\u9818\u57df\uff0cLaduviglusib \u56e0\u5176\u8abf\u7bc0\u764c\u7d30\u80de\u884c\u70ba\u548c\u816b\u7624\u5fae\u74b0\u5883\u7684\u6f5b\u529b\u800c\u5099\u53d7\u95dc\u6ce8\u3002\u8a72\u5316\u5408\u7269\u5df2\u88ab\u8b49\u5be6\u53ef\u900f\u904e\u6291\u88fd\u7cd6\u539f\u5408\u6210\u9176\u6fc0\u91763\uff08GSK3\uff09\u8a98\u5c0e\u591a\u7a2e\u60e1\u6027\u816b\u7624\uff08\u5305\u62ec\u4e0a\u76ae\u6a23\u8089\u7624\u548c\u80ba\u764c\uff09\u7684\u7d30\u80de\u9031\u671f\u963b\u6eef\u3001\u6709\u7d72\u5206\u88c2\u707d\u96e3\u548c\u81ea\u566c\u4f5c\u7528\u3002\u7814\u7a76\u4eba\u54e1\u6b63\u5728\u63a2\u7d22\u5176\u8207\u5176\u4ed6\u5316\u7642\u85e5\u7269\u5408\u4f75\u4f7f\u7528\u6642\u7684\u5354\u540c\u6548\u61c9\uff0c\u4ee5\u514b\u670d\u6297\u85e5\u6027\u3002\u62c9\u675c\u7dad\u683c\u9b6f\u897f\u5e03\u80fd\u5920\u6539\u8b8a\u95dc\u9375\u8a0a\u865f\u901a\u8def\uff0c\u4f7f\u5176\u6210\u70ba\u8b58\u5225\u65b0\u7684\u6cbb\u7642\u6a19\u9776\u548c\u7406\u89e3\u816b\u7624\u75c5\u7406\u751f\u7406\u5b78\u7684\u5bf6\u8cb4\u5de5\u5177\u3002<\/span>\u795e\u7d93\u751f\u7269\u5b78\u548c\u795e\u7d93\u9000\u5316\u6027\u75be\u75c5 (Neurobiology and Neurodegenerative Diseases)<\/span><\/strong>Laduviglusib \u4f48\u5728\u795e\u7d93\u79d1\u5b78\u9818\u57df\u4e2d\u767c\u63ee\u91cd\u8981\u4f5c\u7528\uff0c\u5c24\u5176\u662f\u5728\u6a21\u64ec\u5927\u8166\u767c\u80b2\u548c\u7814\u7a76\u4ea8\u5ef7\u9813\u75c5\u3001\u5e15\u91d1\u68ee\u6c0f\u75c7\u7b49\u795e\u7d93\u9000\u5316\u6027\u75be\u75c5\u65b9\u9762\u3002\u5b83\u5e38\u7528\u65bc\u5efa\u69cb\u4e09\u7dad\u8166\u985e\u5668\u5b98\uff0c\u5291\u91cf\u4f9d\u8cf4\u6027\u7d66\u85e5\u53ef\u8abf\u7bc0\u795e\u7d93\u7956\u7d30\u80de\u7684\u589e\u6b96\u3001\u51cb\u4ea1\u548c\u795e\u7d93\u5143\u9077\u79fb\u3002\u6b64\u5916\uff0c\u5b83\u9084\u6709\u52a9\u65bc\u95e1\u660e\u7279\u5b9a\u8166\u5340\u6c27\u5316\u58d3\u529b\u3001\u9435\u6b7b\u4ea1\u548c\u591a\u5df4\u80fa\u8017\u7aed\u7684\u6a5f\u5236\u3002\u5176\u61c9\u7528\u70ba\u6df1\u5165\u4e86\u89e3\u80da\u80ce\u795e\u7d93\u767c\u751f\u4ee5\u53ca\u56b4\u91cd\u795e\u7d93\u7cfb\u7d71\u75be\u75c5\u80cc\u5f8c\u7684\u8907\u96dc\u7d30\u80de\u52d5\u529b\u5b78\u63d0\u4f9b\u4e86\u91cd\u8981\u7dda\u7d22\u3002<\/span><\/p>\n

<\/p>\n

\n
\n\n\n\n\n\n
Molecular Weight<\/th>\n501.8<\/td>\nFormula<\/th>\nC22<\/sub>H18<\/sub>Cl2<\/sub>N8.<\/sub>HCl<\/td>\nStorage (From the date of receipt)<\/th>\n
CAS No.<\/th>\n1797989-42-4<\/td>\nDownload SDF<\/a><\/td>\nStorage of Stock Solutions<\/th>\n\n
Synonyms<\/th>\nCT99021 HCl<\/td>\nSmiles<\/th>\nCC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N.Cl<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div>\n
<\/div>\n
\"\u7db2\u7ad9\u898f\u683c\u5c0f\u5716_\u5de5\u4f5c\u5340\u57df<\/div>\n<\/div>\n

Selleckchem<\/span><\/span>\u53f0\u7063\u4ee3\u7406\u5546<\/span><\/a><\/span><\/h2>\n

Selleck Chemicals<\/a>\uff0c\u7c21\u7a31 Selleckchem \u6216 Selleck\uff0c\u5c08\u7cbe\u65bc\u9ad8\u54c1\u8cea\u7684\u6291\u5236\u5291 (Inhibitors)<\/a>\u00a0\u548c\u5c0f\u5206\u5b50\u5316\u5408\u7269\u5eab (Compound Libraries)<\/a>\uff0c\u8fd1\u5e74\u4ea6\u63a8\u51fa\u6d3b\u9ad4\u52d5\u7269\u5be6\u9a57\u7528\u6297\u9ad4 (in vivo<\/em>\u00a0antibodies)<\/a>\u00a0\u548c\u751f\u7269\u76f8\u4f3c\u6027\u55ae\u682a\u6297\u9ad4\u85e5\u7269 (biosimilar antibodies)<\/a>\u3002\u622a\u81f3 2025 \u5e74\uff0c\u5df2\u6709\u8d85\u904e 610 \u7bc7\u300aCell\u300b\u300aNature\u300b\u300aScience\u300b\u9802\u5c16\u671f\u520a\u8ad6\u6587\u3001\u00a017 \u4f4d\u8afe\u8c9d\u723e\u734e\u5f97\u4e3b\u63a1\u7528 Selleckchem \u7522\u54c1\uff0c\u54c1\u8cea\u6df1\u53d7\u80af\u5b9a\uff01>>\u66f4\u591aSelleckchem\u5546\u54c1<\/span><\/strong><\/em><\/span><\/a><\/p>\n

\u00a0\"\u539f\u5ee0\u9023\u7d5001\"<\/a><\/strong><\/p>\n

\n<\/div>\n<\/div>\n

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\"Selleck
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<\/h2>\n","protected":false},"excerpt":{"rendered":"

Selleckchem \u7cfb\u5217\u5546\u54c1\/ GSK-3\u6291\u5236\u5291>>Laduviglusib\uff08\u5316\u5b78\u540d\u70ba CHI […]<\/p>\n","protected":false},"author":3,"featured_media":54923,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7083],"tags":[],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/54921"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=54921"}],"version-history":[{"count":1,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/54921\/revisions"}],"predecessor-version":[{"id":54925,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/54921\/revisions\/54925"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/54923"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=54921"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=54921"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=54921"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}