{"id":54867,"date":"2026-06-23T12:21:29","date_gmt":"2026-06-23T04:21:29","guid":{"rendered":"https:\/\/biopioneer.com.tw\/?p=54867"},"modified":"2026-06-23T12:27:28","modified_gmt":"2026-06-23T04:27:28","slug":"sw033291-cas459147-39-8-apexbio%e8%b2%a8%e8%99%9fa8709","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=54867","title":{"rendered":"SW033291 | CAS#459147-39-8 APExBIO\u8ca8\u865fA8709"},"content":{"rendered":"

APExBIO\u7cfb\u5217\u5546\u54c1-\u7d30\u83cc\u6297\u751f\u7d20 ->>SW033291<\/span><\/span><\/span><\/span><\/strong>
\n<\/span><\/span><\/span><\/strong><\/p>\n

APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5291 (Small Molecule Inhibitors)\/\u6d3b\u5316\u5291 (Activators)\u3001\u5316\u5408\u7269\u5eab( Compound Libraries)\u3001\u80dc\u80bd(Peptides)\u3001\u6aa2\u6e2c\u8a66\u5291\u76d2(Assay Kits)\u3001\u87a2\u5149\u6a19\u8a18(Fluorescent Label)\u3001\u9176(Enzymes)\u3001\u4fee\u98fe\u6838\u82f7\u9178(Modified Nucleotides)\u3001mRNA \u5408\u6210\u4ee5\u53ca\u5404\u7a2e\u5206\u5b50\u751f\u7269\u5b78\u5de5\u5177\u7684\u4f9b\u61c9\u5546\u3002APExBIO\u63d0\u4f9b\u5ee3\u6cdb\u7684\u7522\u54c1\u7dda\uff0c\u6db5\u84cb 20 \u591a\u500b\u4e0d\u540c\u7684\u7814\u7a76\u9818\u57df\uff0c\u4f8b\u5982\u764c\u75c7(cancer)\u3001\u514d\u75ab\u5b78(immunology)\u3001\u795e\u7d93\u79d1\u5b78(neurosciences)\u3001\u7d30\u80de\u51cb\u4ea1(apoptosis)\u548c\u8868\u89c0\u907a\u50b3\u5b78(epigenetics)\u7b49\u3002\u516c\u53f8\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u5fb7\u5dde\u4f11\u58eb\u9813USA (Houston, Texas)\uff0c\u81f4\u529b\u65bc\u670d\u52d9\u5168\u7403\u5ba2\u6236\u3002\u9ad8\u5ea6\u91cd\u8996\u7522\u54c1\u54c1\u8cea\u3002\u6240\u6709\u7522\u54c1\u5747\u9075\u5faa\u56b4\u683c\u7684\u751f\u7522\u6307\u5357\uff0c\u4e26\u9644\u6709\u5206\u6790\u8b49\u66f8\u3001HPLC\u3001\u8cea\u8b5c(Mass Spectrum)\u548cHMNR\u4ee5\u53ca\u9ad4\u5916\u9a57\u8b49(in vitro validation)\u3002 APExBIO\u7522\u54c1\u5df2\u88ab\u300aNature\u300b\u3001\u300aCell\u300b\u548c\u300aScience\u300b\u7b49\u773e\u591a\u9802\u7d1a\u540c\u884c\u8a55\u5be9\u671f\u520a\u5f15\u7528\u3002>>\u66f4\u591aAPExBio\u5546\u54c1<\/span><\/strong><\/em><\/span><\/a><\/p>\n

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SW033291 | CAS#459147-39-8 APExBIO\u8ca8\u865fA8709<\/a><\/span><\/p>\n

15-PGDH inhibitor<\/p>\n

\u7522\u54c1\u4ecb\u7d39<\/span><\/strong><\/span><\/p>\n

SW033291\uff08CAS 459147-39-8\uff09\u662f\u4e00\u7a2e\u5c0f\u5206\u5b50\u6291\u5236\u5291(small molecule inhibitor)\uff0c\u91dd\u5c0d\u524d\u5217\u817a\u7d20\u964d\u89e3\u917615-PGDH( prostaglandin-degrading enzyme 15-PGDH)\u3002\u5b83\u4ee5\u975e\u7af6\u722d\u6027\u65b9\u5f0f\u6291\u523615-PGDH\u6d3b\u6027\uff0c\u5177\u6709\u5f37\u6548\u6291\u5236\u4f5c\u7528\uff0cIC50\u503c\u70ba1.5 nM\uff0c\u8868\u89c0\u89e3\u96e2\u5e38\u6578\uff08Ki app\uff09\u7d04\u70ba0.1 nM\u3002 A549\u7d30\u80de\u5be6\u9a57\u8868\u660e\uff0cSW033291\u53ef\u63d0\u9ad8\u524d\u5217\u817a\u7d20E2\uff08PGE2\uff09\u6c34\u5e73\uff08EC50\u7d04\u70ba75 nM\uff09\u3002\u5c0f\u9f20\u9ad4\u5167\u7d66\u85e5SW033291\u53ef\u986f\u8457\u63d0\u9ad8\u7d44\u7e54PGE2\u6fc3\u5ea6\uff0c\u523a\u6fc0\u9020\u8840\u7d30\u80de\u56e0\u5b50\u8868\u9054( hematopoietic cytokine expression)\uff0c\u64f4\u589e\u9020\u8840\u5e79\u7d30\u80de\u548c\u7956\u7d30\u80de\uff0c\u4fc3\u9032\u55dc\u4e2d\u6027\u7403\u589e\u751f\u3002\u56e0\u6b64\uff0cSW033291 \u4ee3\u8868\u4e86\u4e00\u7a2e\u7814\u7a76\u7d44\u7e54\u518d\u751f\u548c\u9020\u8840\u4e2d PGE2 \u76f8\u95dc\u8def\u5f91\u7684\u7814\u7a76\u5de5\u5177\u3002<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
Physical Appearance<\/td>\nA solid<\/td>\n<\/tr>\n
Storage<\/td>\nStore at -20\u00b0C<\/td>\n<\/tr>\n
M.Wt<\/td>\n412.59<\/td>\n<\/tr>\n
Cas No.<\/td>\n459147-39-8<\/td>\n<\/tr>\n
Formula<\/td>\nC21<\/sub>H20<\/sub>N2<\/sub>OS3<\/sub><\/td>\n<\/tr>\n
Solubility<\/td>\ninsoluble in H2O; \u226510.13 mg\/mL in EtOH with ultrasonic; \u226520.65 mg\/mL in DMSO<\/td>\n<\/tr>\n
Chemical Name<\/td>\n2-(butylsulfinyl)-4-phenyl-6-(thiophen-2-yl)thieno[2,3-b]pyridin-3-amine<\/td>\n<\/tr>\n
Canonical SMILES<\/td>\nCCCCS(c([s]c1c2c(-c3ccccc3)cc(-c3ccc[s]3)n1)c2N)=O<\/td>\n<\/tr>\n
Shipping Condition<\/td>\nSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.<\/td>\n<\/tr>\n
General tips<\/td>\nWe do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
<\/div>\n
\"\u7db2\u7ad9\u898f\u683c\u5c0f\u5716_\u5de5\u4f5c\u5340\u57df<\/a><\/div>\n
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APExBIO\u53f0\u7063\u4ee3\u7406\u5546<\/a><\/span><\/strong><\/p>\n<\/div>\n<\/div>\n

https:\/\/www.apexbt.com<\/a><\/span><\/p>\n

APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002<\/p>\n

\"\"\u86cb\u767d\u6291\u5236\u5291\/\u7de9\u885d\u6db2\u6210\u5206<\/span><\/strong><\/span><\/p>\n