{"id":53207,"date":"2025-10-30T11:33:15","date_gmt":"2025-10-30T03:33:15","guid":{"rendered":"https:\/\/biopioneer.com.tw\/?p=53207"},"modified":"2025-11-03T13:56:31","modified_gmt":"2025-11-03T05:56:31","slug":"a23187-free-acid-cas52665-69-7-apexbio%e8%b2%a8%e8%99%9fb6646","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=53207","title":{"rendered":"A23187, free acid | CAS#52665-69-7 APExBIO\u8ca8\u865fB6646"},"content":{"rendered":"

APExBIO\u7cfb\u5217\u5546\u54c1->>A23187, free acid<\/span> CAS#52665-69-7<\/span><\/span><\/span>
\n<\/span><\/span><\/span><\/strong><\/p>\n

APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5291 (Small Molecule Inhibitors)\/\u6d3b\u5316\u5291 (Activators)\u3001\u5316\u5408\u7269\u5eab( Compound Libraries)\u3001\u80dc\u80bd(Peptides)\u3001\u6aa2\u6e2c\u8a66\u5291\u76d2(Assay Kits)\u3001\u87a2\u5149\u6a19\u8a18(Fluorescent Label)\u3001\u9176(Enzymes)\u3001\u4fee\u98fe\u6838\u82f7\u9178(Modified Nucleotides)\u3001mRNA \u5408\u6210\u4ee5\u53ca\u5404\u7a2e\u5206\u5b50\u751f\u7269\u5b78\u5de5\u5177\u7684\u4f9b\u61c9\u5546\u3002APExBIO\u63d0\u4f9b\u5ee3\u6cdb\u7684\u7522\u54c1\u7dda\uff0c\u6db5\u84cb 20 \u591a\u500b\u4e0d\u540c\u7684\u7814\u7a76\u9818\u57df\uff0c\u4f8b\u5982\u764c\u75c7(cancer)\u3001\u514d\u75ab\u5b78(immunology)\u3001\u795e\u7d93\u79d1\u5b78(neurosciences)\u3001\u7d30\u80de\u51cb\u4ea1(apoptosis)\u548c\u8868\u89c0\u907a\u50b3\u5b78(epigenetics)\u7b49\u3002\u516c\u53f8\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u5fb7\u5dde\u4f11\u58eb\u9813USA (Houston, Texas)\uff0c\u81f4\u529b\u65bc\u670d\u52d9\u5168\u7403\u5ba2\u6236\u3002\u9ad8\u5ea6\u91cd\u8996\u7522\u54c1\u54c1\u8cea\u3002\u6240\u6709\u7522\u54c1\u5747\u9075\u5faa\u56b4\u683c\u7684\u751f\u7522\u6307\u5357\uff0c\u4e26\u9644\u6709\u5206\u6790\u8b49\u66f8\u3001HPLC\u3001\u8cea\u8b5c(Mass Spectrum)\u548cHMNR\u4ee5\u53ca\u9ad4\u5916\u9a57\u8b49(in vitro validation)\u3002 APExBIO\u7522\u54c1\u5df2\u88ab\u300aNature\u300b\u3001\u300aCell\u300b\u548c\u300aScience\u300b\u7b49\u773e\u591a\u9802\u7d1a\u540c\u884c\u8a55\u5be9\u671f\u520a\u5f15\u7528\u3002<\/p>\n

<\/p>\n

A23187, free acid | CAS#52665-69-7 APExBIO\u8ca8\u865fB6646<\/a><\/span><\/p>\n

A23187, free acid is a Ca2+ ionophore [1].<\/span><\/p>\n

\u7522\u54c1\u4ecb\u7d39<\/span><\/strong><\/span><\/p>\n

Ca2+ ionophore acts as a Ca2+ ionophore, allowing Ca2+ to cross cell membranes.<\/p>\n

Ca2+\u96e2\u5b50\u8f09\u9ad4(Ca2+ ionophore) \u4f5c\u70ba\u4e00\u7a2eCa2+\u96e2\u5b50\u8f09\u9ad4\uff0c\u80fd\u5920\u4f7fCa2+\u7a7f\u904e\u7d30\u80de\u819c\u3002A23187\uff08\u904a\u96e2\u9178\uff09\u662f\u4e00\u7a2eCa2+\u96e2\u5b50\u8f09\u9ad4\u3002\u5728\u5927\u9f20\u5eab\u666e\u5f17\u7d30\u80de( rat Kupffer cells)\u4e2d\uff0cA23187\u80fd\u5920\u4ee5\u6fc3\u5ea6\u548c\u6642\u9593\u4f9d\u8cf4\u7684\u65b9\u5f0f\u8a98\u5c0e\u78f7\u8102\u9170\u808c\u9187\u6c34\u89e3\u70ba\u808c\u9187\u78f7\u9178\u916f\uff0c\u4e26\u5f9e\u7d30\u80de\u4e2d\u91cb\u653e\u808c\u9187\u78f7\u9178\u916f[1]\u3002\u5728HL-60\u7d30\u80de\u4e2d\uff0cA23187\u80fd\u5920\u63d0\u9ad8\u7d30\u80de\u5167Ca2+\u91cf\u3002\u6b64\u5916\uff0cA23187\u9084\u80fd\u5728\u7d30\u80de\u5167\u548c\u7d30\u80de\u5916\u7522\u751f\u6d3b\u6027\u6c27\uff08ROS\uff09\uff0c\u4e26\u8a98\u5c0e\u7d30\u80de\u51cb\u4ea1\uff0c\u6b64\u904e\u7a0b\u4f9d\u8cf4\u7c92\u7dda\u9ad4\u901a\u900f\u6027\u8f49\u63db[2]\u3002\u5728\u8ff4\u8178\u808c( ileal muscle) \u4e2d\uff0cA23187\uff0810-5 M\uff09\u5728\u7f3a\u6c27\u689d\u4ef6\u4e0b\u8a98\u5c0e\u521d\u59cb\u6536\u7e2e\u548c\u8f15\u5fae\u7684\u7bc0\u5f8b\u6027\u6536\u7e2e\uff0c\u540c\u6642\u5c0e\u81f4\u78f7\u9178\u808c\u9178\uff08PCr\uff09\u3001ATP\u548c\u809d\u91a3\u542b\u91cf\u4e0b\u964d\u3002\u7136\u800c\uff0c\u5728\u7121\u8461\u8404\u7cd6\u57f9\u990a\u57fa\u4e2d\uff0cA23187 (10\u207b\u2075 M) \u53ef\u8a98\u5c0e\u521d\u59cb\u6536\u7e2e\u548c\u96a8\u5f8c\u7684\u7bc0\u5f8b\u6027\u6536\u7e2e\uff0c\u4e26\u986f\u8457\u964d\u4f4e ATP \u548c\u809d\u91a3\u542b\u91cf [3]\u3002\u5728\u5c0d ZnCl\u2082 (250 \u03bcM) \u5177\u6709\u6297\u6027\u7684\u5927\u9f20 C6 \u81a0\u8cea\u7624\u7d30\u80de\u4e2d\uff0cA23187 (100 nM) \u548c Zn\u00b2\u207a (150 \u03bcM) \u5747\u80fd\u986f\u8457\u8a98\u5c0e\u7d30\u80de\u51cb\u4ea1\u3002\u6b64\u5916\uff0cA23187 (1.9 nM) \u53ef\u986f\u8457\u589e\u52a0\u7d30\u80de\u5167\u53ef\u79fb\u52d5\u7684 Zn\u00b2\u207a \u542b\u91cf\u3002\u9019\u4e9b\u7d50\u679c\u8868\u660e\uff0cZn\u00b2\u207a \u548c A23187 \u8a98\u5c0e\u7684\u7d30\u80de\u51cb\u4ea1\u662f\u7531\u65bc A23187 \u8a98\u5c0e\u7684 Zn\u00b2\u207a \u5167\u6d41\u589e\u52a0\u6240\u81f4 [4]\u3002<\/p>\n

<\/p>\n

CAS No. :52665-69-7<\/p>\n

\n\n\n\n\n\n\n\n\n\n
Physical Appearance<\/td>\nA crystalline solid<\/td>\n<\/tr>\n
Storage<\/td>\nStore at 4\u00b0C<\/td>\n<\/tr>\n
M.Wt<\/td>\n523.63<\/td>\n<\/tr>\n
Cas No.<\/td>\n52665-69-7<\/td>\n<\/tr>\n
Formula<\/td>\nC29<\/sub>H37<\/sub>N3<\/sub>O6<\/sub><\/td>\n<\/tr>\n
Solubility<\/td>\nSoluble in DMSO<\/td>\n<\/tr>\n
Chemical Name<\/td>\n5-(methylamino)-2-(((2S,3S,6S,8R,9S,11S)-3,9,11-trimethyl-8-((S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl)-1,7-dioxaspiro[5.5]undecan-2-yl)methyl)benzo[d]oxazole-4-carboxylic acid<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
<\/div>\n
<\/div>\n
\"\u7db2\u7ad9\u898f\u683c\u5c0f\u5716_\u5de5\u4f5c\u5340\u57df<\/a><\/div>\n
<\/div>\n
\n
\n

APExBIO\u53f0\u7063\u4ee3\u7406\u5546<\/a><\/span><\/strong><\/p>\n<\/div>\n<\/div>\n

https:\/\/www.apexbt.com<\/a><\/span><\/p>\n

APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002<\/p>\n

\"\u578b\u9304\u4e0b\u8f09\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

APExBIO\u7cfb\u5217\u5546\u54c1->>A23187, free acid CAS#52665-69-7 AP […]<\/p>\n","protected":false},"author":3,"featured_media":47343,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5368],"tags":[7008,7009],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/53207"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=53207"}],"version-history":[{"count":1,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/53207\/revisions"}],"predecessor-version":[{"id":53208,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/53207\/revisions\/53208"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/47343"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=53207"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=53207"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=53207"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}