{"id":52118,"date":"2025-07-28T17:16:00","date_gmt":"2025-07-28T09:16:00","guid":{"rendered":"https:\/\/biopioneer.com.tw\/?p=52118"},"modified":"2025-11-15T16:37:42","modified_gmt":"2025-11-15T08:37:42","slug":"%e7%b4%b0%e8%83%9e%e9%ac%86%e5%bc%9b%e7%b4%a0d-cytochalasin-d-cas22144-77-0-apexbio%e8%b2%a8%e8%99%9fb6645","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=52118","title":{"rendered":"\u7d30\u80de\u9b06\u5f1b\u7d20D (Cytochalasin D) | CAS#22144-77-0 APExBIO\u8ca8\u865fB6645"},"content":{"rendered":"

APExBIO\u7cfb\u5217\u5546\u54c1->>\u7d30\u80de\u9b06\u5f1b\u7d20D <\/span><\/span><\/span>(Cytochalasin D)<\/span> CAS#22144-77-0 <\/a><\/span><\/span>
\n<\/span><\/span><\/span><\/strong><\/p>\n

APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5291 (Small Molecule Inhibitors)\/\u6d3b\u5316\u5291 (Activators)\u3001\u5316\u5408\u7269\u5eab( Compound Libraries)\u3001\u80dc\u80bd(Peptides)\u3001\u6aa2\u6e2c\u8a66\u5291\u76d2(Assay Kits)\u3001\u87a2\u5149\u6a19\u8a18(Fluorescent Label)\u3001\u9176(Enzymes)\u3001\u4fee\u98fe\u6838\u82f7\u9178(Modified Nucleotides)\u3001mRNA \u5408\u6210\u4ee5\u53ca\u5404\u7a2e\u5206\u5b50\u751f\u7269\u5b78\u5de5\u5177\u7684\u4f9b\u61c9\u5546\u3002APExBIO\u63d0\u4f9b\u5ee3\u6cdb\u7684\u7522\u54c1\u7dda\uff0c\u6db5\u84cb 20 \u591a\u500b\u4e0d\u540c\u7684\u7814\u7a76\u9818\u57df\uff0c\u4f8b\u5982\u764c\u75c7(cancer)\u3001\u514d\u75ab\u5b78(immunology)\u3001\u795e\u7d93\u79d1\u5b78(neurosciences)\u3001\u7d30\u80de\u51cb\u4ea1(apoptosis)\u548c\u8868\u89c0\u907a\u50b3\u5b78(epigenetics)\u7b49\u3002\u516c\u53f8\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u5fb7\u5dde\u4f11\u58eb\u9813USA (Houston, Texas)\uff0c\u81f4\u529b\u65bc\u670d\u52d9\u5168\u7403\u5ba2\u6236\u3002\u9ad8\u5ea6\u91cd\u8996\u7522\u54c1\u54c1\u8cea\u3002\u6240\u6709\u7522\u54c1\u5747\u9075\u5faa\u56b4\u683c\u7684\u751f\u7522\u6307\u5357\uff0c\u4e26\u9644\u6709\u5206\u6790\u8b49\u66f8\u3001HPLC\u3001\u8cea\u8b5c(Mass Spectrum)\u548cHMNR\u4ee5\u53ca\u9ad4\u5916\u9a57\u8b49(in vitro validation)\u3002 APExBIO\u7522\u54c1\u5df2\u88ab\u300aNature\u300b\u3001\u300aCell\u300b\u548c\u300aScience\u300b\u7b49\u773e\u591a\u9802\u7d1a\u540c\u884c\u8a55\u5be9\u671f\u520a\u5f15\u7528\u3002>>\u66f4\u591aAPExBio\u5546\u54c1<\/span><\/strong><\/em><\/span><\/a><\/p>\n

<\/p>\n

\u7d30\u80de\u9b06\u5f1b\u7d20D (Cytochalasin D) | CAS#22144-77-0 APExBIO\u8ca8\u865fB6645<\/a><\/span><\/p>\n

\u7522\u54c1\u4ecb\u7d39<\/span><\/strong><\/span><\/p>\n

\u7d30\u80de\u9b06\u5f1b\u7d20D (Cytochalasin D) \u662f\u4e00\u7a2e\u9078\u64c7\u6027\u808c\u52d5\u86cb\u767d\u805a\u5408\u6291\u5236\u5291\uff0cIC50\u503c\u70ba25 nM [1]\u3002\u808c\u52d5\u86cb\u767d(Actin)\u662f\u4e00\u7a2e\u7403\u72c0\u591a\u529f\u80fd\u86cb\u767d(globular multi-functional protein)\uff0c\u5e7e\u4e4e\u5b58\u5728\u65bc\u6240\u6709\u771f\u6838\u7d30\u80de\u4e2d\u3002\u7814\u7a76\u8868\u660e\uff0c\u808c\u52d5\u86cb\u767d\u805a\u5408\u5728\u7d30\u80de\u8da8\u5316\u548c\u80de\u8cea\u5206\u88c2\u4e2d\u8d77\u8457\u95dc\u9375\u4f5c\u7528\u3002\u64da\u5831\u9053\uff0c (Cytochalasin D) \u900f\u904e\u7834\u58de\u808c\u52d5\u86cb\u767d\u5fae\u7d72\u4e26\u6d3b\u5316p53\u4f9d\u8cf4\u6027\u901a\u8def\uff0c\u6291\u5236\u808c\u52d5\u86cb\u767d\u805a\u5408\uff0c\u9032\u800c\u5c0e\u81f4\u7d30\u80de\u9031\u671f\u5728G1-S\u671f\u505c\u6eef\uff0c\u9032\u800c\u6291\u5236\u808c\u52d5\u86cb\u767d\u805a\u5408\u904e\u7a0b[2]\u3002\u7d30\u80de\u9b06\u5f1b\u7d20D (Cytochalasin D) \u662f\u4e00\u7a2e\u5f37\u6548\u7684\u808c\u52d5\u86cb\u767d\u805a\u5408\u6291\u5236\u5291\u3002\u5728\u5206\u5316\u795e\u7d93\u5143(differentiating neurons)\u4e2d\uff0c\u7d30\u80de\u9b06\u5f1b\u7d20D\u900f\u904e\u6291\u5236\u808c\u52d5\u86cb\u767d\u805a\u5408\uff0c\u6e1b\u7de9\u4e86\u4f38\u9577\/\u56de\u7e2e\u9031\u671f\uff0c\u4e26\u964d\u4f4e\u4e86\u677f\u72c0\u507d\u8db3\u7684\u8ef8\u5411\u904b\u52d5[1]\u3002\u5728\u4e0a\u76ae\u7d30\u80de\u682aHEp-2\u7d30\u80de (epithelial cell line HEp-2 cells) \u4e2d\uff0c\u7d30\u80de\u9b06\u5f1b\u7d20D (Cytochalasin D)\u6cbb\u7642\u53ef\u900f\u904e\u963b\u65b7\u808c\u52d5\u86cb\u767d\u805a\u5408\u4f86\u8abf\u7bc0\u75c5\u6bd2\u8f49\u9304\u7684\u665a\u671f\u548c\u6975\u665a\u671f\uff0c\u4e26\u95dc\u9589\u5bbf\u4e3b\u8f49\u9304[3]\u3002\u5728\u611f\u67d3PCV2\u7684IPEC-J2\u7d30\u80de\u6a21\u578b\u4e2d\uff0c\u7d30\u80de\u9b06\u5f1b\u7d20D (Cytochalasin D )\u6cbb\u7642\u53ef\u4ee5\u6291\u5236PCV2\u7684\u4fb5\u8972\u3001\u8907\u88fd\u548c\u91cb\u653e\uff0c\u9032\u800c\u6291\u5236\u75c5\u6bd2\u7684\u5165\u4fb5 (virus invasion) [4]<\/p>\n

<\/p>\n

\u7d30\u80de\u5be6\u9a57<\/p>\n

\u5728HeLa\u3001Vero\u3001L\u3001HEp2\u548cMDBK\u7d30\u80de\u4e2d\uff0c\u7d30\u80de\u9b06\u5f1b\u7d20D\uff080.2-0.5 \u03bcg\/mL\uff09\u8a98\u5c0e\u6301\u7e8c\u6536\u7e2e\uff08\u6523\u7e2e\uff09\u3001\u5fae\u7d68\u6bdb\u812b\u843d\u3001\u5167\u8cea\u5167\u5bb9\u7269\u8868\u9054\uff08\u7d30\u80de\u840e\u7e2e\uff09\u3001\u7d30\u80de\u6838\u7a81\u51fa\u548c\u80de\u8cea\u7a81\u8d77\u5ef6\u4f38\u3002 G1\u671f\u7d30\u80de\u5c0dCD\u6700\u654f\u611f\uff1b\u5728S\u65e9\u671f\uff0c\u53cd\u61c9\u6027\u9010\u6f38\u964d\u4f4e\uff0c\u5728S\u4e2d\u671f\u81f3G2\u671f\uff0c\u53cd\u61c9\u6027\u6700\u5dee\u3002 CD\u6291\u5236\u4e86HeLa\u7d30\u80de\u4e2d[14C]\u812b\u6c27\u8461\u8404\u7cd6\u7684\u8f49\u904b\u3002\u5728SC-1\u7d30\u80de\u4e2d\uff0c\u7d30\u80de\u9b06\u5f1b\u7d20D\u8655\u7406\u56b4\u91cd\u7834\u58de\u4e86\u7db2\u72c0\u7d44\u7e54\uff0c\u589e\u52a0\u4e86\u808c\u52d5\u86cb\u767d\u7d72\u672b\u7aef\u7684\u6578\u91cf\uff0c\u4e26\u5c0e\u81f4\u4e3b\u8981\u7531\u808c\u52d5\u86cb\u767d\u7d72\u7d44\u6210\u7684\u7d72\u72c0\u805a\u96c6\u9ad4\u6216\u805a\u96c6\u7076\u7684\u5f62\u6210\u3002\u7d30\u80de\u9b06\u5f1b\u7d20D\uff080.24-15 \u03bcg\/mL\uff0c16\u5c0f\u6642\uff09\u4ee5\u6642\u9593\u548c\u5291\u91cf\u4f9d\u8cf4\u6027\u65b9\u5f0f\u6291\u5236CT26\u816b\u7624\u7d30\u80de\u589e\u6b96\uff0c\u4e26\u8a98\u5c0e\u986f\u8457\u7684CT26\u7d30\u80de\u51cb\u4ea1\u3002<\/p>\n

\u52d5\u7269\u5be6\u9a57 \r\n\r\n\u7d30\u80de\u9b06\u5f1b\u7d20D\uff08\u975c\u8108\u6ce8\u5c04\uff0c50 mg\/kg\uff09\u9ad4\u5167\u6cbb\u7642\u986f\u8457\u6291\u5236\u4e86CT26\u8377\u7624\u5c0f\u9f20\u7684\u816b\u7624\u751f\u9577\uff0c\u4e26\u5ef6\u9577\u4e86\u5176\u5b58\u6d3b\u6642\u9593\u3002\u5728\u8c6c\u51a0\u72c0\u52d5\u8108\u6a21\u578b\u4e2d\uff0c\u4f4e\u5291\u91cf\u7d30\u80de\u9b06\u5f1b\u7d20D\uff082 \u03bcg\uff09\u53ef\u6e1b\u5c11\u665a\u671f\u7ba1\u8154\u55aa\u5931\u3002\r\n\u9ad8\u5291\u91cf\u7d30\u80de\u9b06\u5f1b\u7d20D\uff0820 \u03bcg\uff09\u53ef\u540c\u6642\u6291\u5236\u665a\u671f\u7ba1\u8154\u6d41\u5931\u548c\u5167\u819c\u9762\u7a4d\u3002\r\n<\/span><\/pre>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Physical Appearance<\/td>\nA crystalline solid<\/td>\n<\/tr>\n
Storage<\/td>\nDesiccate at -20\u00b0C<\/td>\n<\/tr>\n
M.Wt<\/td>\n507.63<\/td>\n<\/tr>\n
Cas No.<\/td>\n22144-77-0<\/td>\n<\/tr>\n
Formula<\/td>\nC30<\/sub>H37<\/sub>NO6<\/sub><\/td>\n<\/tr>\n
Solubility<\/td>\nSoluble in DMSO<\/td>\n<\/tr>\n
Chemical Name<\/td>\n(3S,3aR,4R,6R,6aS,7E,10R,12S,13Z,15R,15aS)-3-benzyl-6,12-dihydroxy-4,10,12-trimethyl-5-methylene-1,11-dioxo-2,3,3a,4,5,6,6a,9,10,11,12,15-dodecahydro-1H-cycloundeca[d]isoindol-15-yl acetate<\/td>\n<\/tr>\n
SDF<\/td>\nDownload SDF<\/a><\/td>\n<\/tr>\n
Canonical SMILES<\/td>\nO[C@@H]1[C@@H](\/C=C\/C[C@@H](C)C2=O)[C@]3([C@@H](C=C[C@]2(C)O)OC(C)=O)[C@@H]([C@@H](C)C1=C)[C@H](CC4=CC=CC=C4)NC3=O<\/td>\n<\/tr>\n
Shipping Condition<\/td>\nSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.<\/td>\n<\/tr>\n
General tips<\/td>\nWe do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
References:<\/em><\/p>\n
[1] Sayyad, W.A., et al., The role of myosin-II in force generation of DRG filopodia and lamellipodia. Sci Rep, 2015. 5: p. 7842.<\/em>
\n[2] Montazeri, M., et al., Activation of Toll-like receptor 3 reduces actin polymerization and adhesion molecule expression in endometrial cells, a potential mechanism for viral-induced implantation failure. Hum Reprod, 2015.<\/em>
\n[3] Volkman, L.E., Baculoviruses and nucleosome management. Virology, 2015. 476c: p. 257-263.<\/em>
\n[4] Yan, M., L. Zhu, and Q. Yang, Infection of porcine circovirus 2 (PCV2) in intestinal porcine epithelial cell line (IPEC-J2) and interaction between PCV2 and IPEC-J2 microfilaments. Virol J, 2014. 11: p. 193.<\/em><\/p>\n
<\/p>\n
<\/p>\n
<\/p>\n
\n
Product Citation<\/span><\/strong><\/span><\/h2>\n