{"id":52106,"date":"2025-07-28T16:45:01","date_gmt":"2025-07-28T08:45:01","guid":{"rendered":"https:\/\/biopioneer.com.tw\/?p=52106"},"modified":"2026-01-16T16:50:51","modified_gmt":"2026-01-16T08:50:51","slug":"%e7%a7%8b%e6%b0%b4%e4%bb%99%e9%b9%bccolchicine-cas64-86-8-apexbio%e8%b2%a8%e8%99%9f-a3324","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=52106","title":{"rendered":"\u79cb\u6c34\u4ed9\u9e7c(Colchicine) | CAS#64-86-8 APExBIO\u8ca8\u865f A3324"},"content":{"rendered":"

APExBIO\u7cfb\u5217\u5546\u54c1->><\/span><\/span>\u79cb\u6c34\u4ed9\u9e7c(Colchicine) CAS#64-86-8 <\/a><\/span><\/span>
\n<\/span><\/span><\/span><\/strong><\/p>\n

APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5291 (Small Molecule Inhibitors)\/\u6d3b\u5316\u5291 (Activators)\u3001\u5316\u5408\u7269\u5eab( Compound Libraries)\u3001\u80dc\u80bd(Peptides)\u3001\u6aa2\u6e2c\u8a66\u5291\u76d2(Assay Kits)\u3001\u87a2\u5149\u6a19\u8a18(Fluorescent Label)\u3001\u9176(Enzymes)\u3001\u4fee\u98fe\u6838\u82f7\u9178(Modified Nucleotides)\u3001mRNA \u5408\u6210\u4ee5\u53ca\u5404\u7a2e\u5206\u5b50\u751f\u7269\u5b78\u5de5\u5177\u7684\u4f9b\u61c9\u5546\u3002APExBIO\u63d0\u4f9b\u5ee3\u6cdb\u7684\u7522\u54c1\u7dda\uff0c\u6db5\u84cb 20 \u591a\u500b\u4e0d\u540c\u7684\u7814\u7a76\u9818\u57df\uff0c\u4f8b\u5982\u764c\u75c7(cancer)\u3001\u514d\u75ab\u5b78(immunology)\u3001\u795e\u7d93\u79d1\u5b78(neurosciences)\u3001\u7d30\u80de\u51cb\u4ea1(apoptosis)\u548c\u8868\u89c0\u907a\u50b3\u5b78(epigenetics)\u7b49\u3002\u516c\u53f8\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u5fb7\u5dde\u4f11\u58eb\u9813USA (Houston, Texas)\uff0c\u81f4\u529b\u65bc\u670d\u52d9\u5168\u7403\u5ba2\u6236\u3002\u9ad8\u5ea6\u91cd\u8996\u7522\u54c1\u54c1\u8cea\u3002\u6240\u6709\u7522\u54c1\u5747\u9075\u5faa\u56b4\u683c\u7684\u751f\u7522\u6307\u5357\uff0c\u4e26\u9644\u6709\u5206\u6790\u8b49\u66f8\u3001HPLC\u3001\u8cea\u8b5c(Mass Spectrum)\u548cHMNR\u4ee5\u53ca\u9ad4\u5916\u9a57\u8b49(in vitro validation)\u3002 APExBIO\u7522\u54c1\u5df2\u88ab\u300aNature\u300b\u3001\u300aCell\u300b\u548c\u300aScience\u300b\u7b49\u773e\u591a\u9802\u7d1a\u540c\u884c\u8a55\u5be9\u671f\u520a\u5f15\u7528\u3002>>\u66f4\u591aAPExBio\u5546\u54c1<\/span><\/strong><\/em><\/span><\/a><\/p>\n

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\u79cb\u6c34\u4ed9\u9e7c(Colchicine) | CAS#64-86-8 APExBIO\u8ca8\u865f A3324<\/a><\/span><\/p>\n

\u7522\u54c1\u4ecb\u7d39<\/span><\/strong><\/span><\/p>\n

\u79cb\u6c34\u4ed9\u9e7c(Colchicine)\u662f\u4e00\u7a2e\u5fae\u7ba1\u86cb\u767d\u6291\u5236\u5291 (tubulin inhibitor)\uff0c\u900f\u904e\u8207\u5fae\u7ba1\u86cb\u767d(microtubules) \u7d50\u5408\u4f86\u963b\u65b7\u5fae\u7ba1\u805a\u5408\uff08IC50 = 3.2 \u03bcM\uff09\u3002\u5fae\u7ba1\u86cb\u767d(microtubules) \u662f\u7403\u72c0\u86cb\u767d\u5c0f\u5bb6\u65cf\u7684\u5e7e\u500b\u6210\u54e1\u4e4b\u4e00\u3002\u5fae\u7ba1\u86cb\u767d\u8d85\u5bb6\u65cf\u5305\u542b\u4e94\u500b\u4e0d\u540c\u7684\u5bb6\u65cf\u3002\u70ba\u4e86\u5f62\u6210\u5fae\u7ba1\uff0c\u03b1-\u548c\u03b2-\u5fae\u7ba1\u86cb\u767d\u7684\u4e8c\u805a\u9ad4\u8207GTP\u7d50\u5408\uff0c\u4e26\u5728GTP\u7d50\u5408\u72c0\u614b\u4e0b\u7d44\u88dd\u5230\u5fae\u7ba1\u7684(+)\u7aef\u3002 [1] \u03b2-\u5fae\u7ba1\u86cb\u767d\u4e9e\u57fa\u66b4\u9732\u5728\u5fae\u7ba1\u7684\u6b63\u7aef\uff0c\u800c\u03b1-\u5fae\u7ba1\u86cb\u767d\u4e9e\u57fa\u5247\u66b4\u9732\u5728\u8ca0\u7aef\u3002\u4e8c\u805a\u9ad4\u88ab\u6574\u5408\u5230\u5fae\u7ba1\u5f8c\uff0c\u8207\u03b2-\u5fae\u7ba1\u86cb\u767d\u4e9e\u57fa\u7d50\u5408\u7684GTP\u5206\u5b50\u6700\u7d42\u900f\u904e\u6cbf\u8457\u5fae\u7ba1\u539f\u7d72\u7684\u4e8c\u805a\u9ad4\u9593\u63a5\u89f8\u6c34\u89e3\u70baGDP\u3002 [2] \u9019\u5c31\u662fGTP\u5faa\u74b0\uff0c\u5b83\u5c0d\u65bc\u5fae\u7ba1\u7684\u52d5\u614b\u4e0d\u7a69\u5b9a\u6027\u81f3\u95dc\u91cd\u8981\u3002\u79cb\u6c34\u4ed9\u9e7c(Colchicine)\u900f\u904e\u8207\u5fae\u7ba1\u7684\u4e3b\u8981\u6210\u5206\u4e4b\u4e00\u5fae\u7ba1\u86cb\u767d\u7d50\u5408\u4f86\u6291\u5236\u5fae\u7ba1\u805a\u5408\u3002\u5fae\u7ba1\u86cb\u767d\u7684\u53ef\u7528\u6027\u5c0d\u65bc\u6709\u7d72\u5206\u88c2\u81f3\u95dc\u91cd\u8981\uff0c\u56e0\u6b64\u79cb\u6c34\u4ed9\u9e7c\u6709\u6548\u5730\u767c\u63ee\u4e86\u300c\u6709\u7d72\u5206\u88c2\u6bd2\u300d\u6216\u7d21\u9318\u9ad4\u6bd2\u7684\u4f5c\u7528\u3002 [3] \u56e0\u6b64\uff0c\u6709\u7d72\u5206\u88c2\u53ef\u4ee5\u5728\u7d30\u80de\u9031\u671f\u4e2d\u671f\uff08\u7279\u5225\u662f\u4e2d\u671f\uff09\u5b8c\u6210\u4e4b\u524d\u505c\u6b62\u3002\u9664\u4e86\u6291\u5236\u6709\u7d72\u5206\u88c2\u5916\uff0c\u79cb\u6c34\u4ed9\u9e7c\u9084\u80fd\u6291\u5236\u55dc\u4e2d\u6027\u7403\u7684\u904b\u52d5\u548c\u6d3b\u6027\uff0c\u5728\u5c0f\u9f20\u75db\u98a8\u6027\u95dc\u7bc0\u708e\u6a21\u578b\u4e2d\uff0c5 \u03bcmol\/kg \u5291\u91cf\u7684\u79cb\u6c34\u4ed9\u9e7c\u53ef\u7522\u751f\u6de8\u6297\u767c\u708e\u4f5c\u7528\uff0c\u4e26\u6291\u5236\u5c3f\u9178\u6c89\u7a4d\uff0c\u9019\u662f\u75db\u98a8\u6cbb\u7642\u7684\u95dc\u9375\u65b9\u9762\u3002 [4] \u526f\u4f5c\u7528\u5305\u62ec\u80c3\u8178\u4e0d\u9069\u548c\u55dc\u4e2d\u6027\u767d\u8840\u7403\u6e1b\u5c11\u75c7\u3002\u9ad8\u5291\u91cf\u4e5f\u6703\u640d\u5bb3\u9aa8\u9ad3(bone marrow )\uff0c\u5c0e\u81f4\u8ca7\u8840( anemia)\u548c\u6389\u9aee\u3002<\/p>\n

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References:<\/em>
\n1. Heald R, Nogales E. “Microtubule dynamics”. J. Cell. Sci. 2002,115 (Pt 1): 3\u20134.<\/em>
\n2. Howard J, Hyman A. “Dynamics and mechanics of the microtubule plus end”. Nature 2003,422 (6933): 753\u20138.<\/em>
\n3. “Information for Healthcare Professionals: New Safety Information for Colchicine (marketed as Colcrys)”. U.S. Food and Drug Administration.<\/em>
\n4. Chen LX, Schumacher HR. “Gout: an evidence-based review”. J Clin Rheumatol 2008, 14: S55\u201362.<\/em>
\n5. Colchicine. National Institute for Occupational Safety and Health. Emergency Response Safety and Health Database, August 22, 2008. Retrieved December 23, 2008.<\/em><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Physical Appearance<\/td>\nA solid<\/td>\n<\/tr>\n
Storage<\/td>\nStore at -20\u00b0C<\/td>\n<\/tr>\n
M.Wt<\/td>\n399.44<\/td>\n<\/tr>\n
Cas No.<\/td>\n64-86-8<\/td>\n<\/tr>\n
Formula<\/td>\nC22<\/sub>H25<\/sub>NO6<\/sub><\/td>\n<\/tr>\n
Solubility<\/td>\n\u226519.97 mg\/mL in DMSO; \u226545.5 mg\/mL in H2O with gentle warming; \u226550.8 mg\/mL in EtOH with gentle warming<\/td>\n<\/tr>\n
Chemical Name<\/td>\nN-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide<\/td>\n<\/tr>\n
SDF<\/td>\nDownload SDF<\/a><\/td>\n<\/tr>\n
Canonical SMILES<\/td>\nCOC1=C(C(C([C@@H](NC(C)=O)CC2)=C3)=CC=C(OC)C3=O)C2=CC(OC)=C1OC<\/td>\n<\/tr>\n
Shipping Condition<\/td>\nSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.<\/td>\n<\/tr>\n
General tips<\/td>\nWe do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
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Product Citation<\/span><\/strong><\/span><\/h2>\n

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