{"id":52031,"date":"2025-07-15T13:12:08","date_gmt":"2025-07-15T05:12:08","guid":{"rendered":"https:\/\/biopioneer.com.tw\/?p=52031"},"modified":"2025-11-15T16:38:20","modified_gmt":"2025-11-15T08:38:20","slug":"%e7%94%b2%e7%a3%ba%e9%85%b8%e5%8e%bb%e9%90%b5%e8%83%badeferoxamine-mesylate-cas138-14-7-apexbio%e8%b2%a8%e8%99%9fb6068","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=52031","title":{"rendered":"\u7532\u78fa\u9178\u53bb\u9435\u80fa(Deferoxamine mesylate) | CAS#138-14-7 APExBIO\u8ca8\u865fB6068"},"content":{"rendered":"<p><strong><span style=\"font-size: 12pt; color: #ff6600;\"><span style=\"font-size: 14pt;\"><span style=\"color: #800080;\">\u5929\u7136\u7522\u54c1\u7cfb\u5217\u5546\u54c1-&gt;&gt;<\/span><\/span><\/span><span style=\"color: #ff6600;\"><span style=\"font-size: 12pt;\"><span style=\"font-size: 14pt;\">\u7532\u78fa\u9178\u53bb\u9435\u80fa<\/span><\/span><span style=\"font-size: 12pt;\"><span style=\"font-size: 14pt;\">(Deferoxamine mesylate)<\/span><\/span><\/span><span style=\"font-size: 12pt; color: #ff6600;\"><span style=\"font-size: 14pt;\"><span style=\"color: #800080;\"><br \/>\n<\/span><\/span><\/span><\/strong><\/p>\n<p>APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5291 (Small Molecule Inhibitors)\/\u6d3b\u5316\u5291(Activators)\u3001\u5316\u5408\u7269\u5eab( Compound Libraries)\u3001\u80dc\u80bd(Peptides)\u3001\u6aa2\u6e2c\u8a66\u5291\u76d2(Assay Kits)\u3001\u87a2\u5149\u6a19\u8a18(Fluorescent Label)\u3001\u9176(Enzymes)\u3001\u4fee\u98fe\u6838\u82f7\u9178(Modified Nucleotides)\u3001mRNA \u5408\u6210\u4ee5\u53ca\u5404\u7a2e\u5206\u5b50\u751f\u7269\u5b78\u5de5\u5177\u7684\u4f9b\u61c9\u5546\u3002APExBIO\u63d0\u4f9b\u5ee3\u6cdb\u7684\u7522\u54c1\u7dda\uff0c\u6db5\u84cb 20 \u591a\u500b\u4e0d\u540c\u7684\u7814\u7a76\u9818\u57df\uff0c\u4f8b\u5982\u764c\u75c7(cancer)\u3001\u514d\u75ab\u5b78(immunology)\u3001\u795e\u7d93\u79d1\u5b78(neurosciences)\u3001\u7d30\u80de\u51cb\u4ea1(apoptosis)\u548c\u8868\u89c0\u907a\u50b3\u5b78(epigenetics)\u7b49\u3002\u516c\u53f8\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u5fb7\u5dde\u4f11\u58eb\u9813USA (Houston, Texas)\uff0c\u81f4\u529b\u65bc\u670d\u52d9\u5168\u7403\u5ba2\u6236\u3002\u9ad8\u5ea6\u91cd\u8996\u7522\u54c1\u54c1\u8cea\u3002\u6240\u6709\u7522\u54c1\u5747\u9075\u5faa\u56b4\u683c\u7684\u751f\u7522\u6307\u5357\uff0c\u4e26\u9644\u6709\u5206\u6790\u8b49\u66f8\u3001HPLC\u3001\u8cea\u8b5c(Mass Spectrum)\u548cHMNR\u4ee5\u53ca\u9ad4\u5916\u9a57\u8b49(in vitro validation)\u3002 APExBIO\u7522\u54c1\u5df2\u88ab\u300aNature\u300b\u3001\u300aCell\u300b\u548c\u300aScience\u300b\u7b49\u773e\u591a\u9802\u7d1a\u540c\u884c\u8a55\u5be9\u671f\u520a\u5f15\u7528\u3002<a href=\"https:\/\/biopioneer.com.tw\/?news=apexbio%e5%8f%b0%e7%81%a3%e4%bb%a3%e7%90%86%e5%95%86-brandagency%e4%bb%a3%e7%90%86%e5%93%81%e7%89%8c-apexbio-2\"><span style=\"color: #ff0000;\"><em><strong><span style=\"text-decoration: underline;\">&gt;&gt;\u66f4\u591aAPExBio\u5546\u54c1<\/span><\/strong><\/em><\/span><\/a><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"https:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2025\/06\/%E5%A4%AA%E9%BC%8E-APExBIO-Technology-LLC-%E5%93%81%E7%89%8C.png\" width=\"1099\" height=\"274\" \/><\/p>\n<p><span style=\"color: #33cccc;\"><a style=\"color: #33cccc;\" href=\"https:\/\/biopioneer.com.tw\/?p=52031&amp;preview=true\">\u7532\u78fa\u9178\u53bb\u9435\u80fa(Deferoxamine mesylate)| CAS#138-14-7 APExBIO\u8ca8\u865fB6068<\/a><\/span><\/p>\n<p><span style=\"color: #800000;\"><strong><span style=\"font-size: 12pt;\">\u7522\u54c1\u4ecb\u7d39<\/span><\/strong><\/span><\/p>\n<p>\u7532\u78fa\u9178\u53bb\u9435\u80fa(Deferoxamine mesylate ) \u662f\u4e00\u7a2e\u7279\u7570\u6027\u7684\u9435\u87af\u5408\u5291 ( iron-chelating agent) [1][2][3] \u7532\u78fa\u9178\u53bb\u9435\u80fa(Deferoxamine mesylate )\u53ef\u7528\u65bc\u6cbb\u7642\u6025\u6027\u9435\u4e2d\u6bd2\u3002\u53bb\u9435\u80fa\u8207\u9435\u7d61\u5408\u5f62\u6210\u9435\u80fa\uff0c\u963b\u6b62\u9435\u53c3\u8207\u9032\u4e00\u6b65\u7684\u5316\u5b78\u53cd\u61c9\u3002\u5f62\u6210\u7684\u87af\u5408\u7269\u6613\u6eb6\u65bc\u6c34\uff0c\u4e26\u80fd\u8f15\u9b06\u901a\u904e\u814e\u81df[1]\u3002\u5728\u79fb\u690d\u4e8613762NF\u4e73\u764c\u7d30\u80de\u7684Fisher\u5927\u9f20\u4e2d\uff0c\u7532\u78fa\u9178\u53bb\u9435\u80fa(Deferoxamine mesylate ) \u6291\u5236\u4e86\u8a72\u5927\u9f20\u7684\u816b\u7624\u751f\u9577\u3002\u800c\u6ce8\u5c04\u7532\u78fa\u9178\u53bb\u9435\u80fa(Deferoxamine mesylate ) \u5408\u4f75\u4f4e\u9435\u98f2\u98df\u5c0d\u816b\u7624\u751f\u9577\u7684\u6291\u5236\u6548\u679c\u6700\u4f73\u3002\u7532\u78fa\u9178\u53bb\u9435\u80fa(Deferoxamine mesylate ) \u80fd\u662f\u4e00\u7a2e\u6709\u6548\u7684\u4e73\u764c\u5316\u7642\u85e5\u7269[2]\u3002\u5728Sprague-Dawley\u5927\u9f20\u4e2d\uff0c\u624b\u8853\u524d\u7d93\u8179\u8154\u52d5\u8108\u6ce8\u5c04\u7532\u78fa\u9178\u53bb\u9435\u80fa(Deferoxamine mesylate ) \uff0875-90\u6beb\u514b\uff1b300\u6beb\u514b\/\u516c\u65a4\uff09\u3002\u7532\u78fa\u9178\u53bb\u9435\u80fa(Deferoxamine mesylate ) \u986f\u8457\u964d\u4f4e\u539f\u4f4d\u809d\u81df\u81ea\u9ad4\u79fb\u690d\u8853\u5f8c\u8840\u6e05\u6fb1\u7c89\u9176\u3001\u8102\u80aa\u9176\u548c\u4e19\u4e8c\u919b (MDA) \u6c34\u5e73\u3002\u7532\u78fa\u9178\u53bb\u9435\u80fa(Deferoxamine mesylate ) \u4e5f\u900f\u904e\u4e0a\u8abf HIF-1 \u86cb\u767d\u8868\u73fe\u548c\u6291\u5236\u6c27\u5316\u6bd2\u6027\u53cd\u61c9\u4f86\u4fdd\u8b77\u80f0\u81df\u7d44\u7e54 [3]\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"https:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2025\/07\/2-%E7%94%B2%E7%A3%BA%E9%85%B8%E5%8E%BB%E9%90%B5%E8%83%BADeferoxamine-mesylate-CAS138-14-7-APExBIO%E8%B2%A8%E8%99%9FB6068.jpg\" width=\"411\" height=\"542\" \/><\/p>\n<div id=\"cite\" class=\"tbar\">\n<h2><span style=\"font-size: 12pt; color: #993300;\">Product Citation<\/span><\/h2>\n<\/div>\n<div class=\"detail-table \">\n<div class=\"detail-box-cont\">\n<ul id=\"artul\">\n<li><a href=\"https:\/\/doi.org\/10.1016\/j.tranon.2025.102393\" target=\"_blank\" rel=\"noopener\">1. Chao Wang, Yin-Lin Zha, et al. &#8220;Carfilzomib promotes Iodine-125 seed radiation-induced apoptosis, paraptosis, and ferroptosis in esophageal squamous cell carcinoma by aggravating endoplasmic reticulum stress.&#8221; Transl Oncol. 2025 Jul:57:102393. PMID: 40315760<\/a><\/li>\n<li><a href=\"https:\/\/doi.org\/10.21203\/rs.3.rs-4020612\/v1\" target=\"_blank\" rel=\"noopener\">2. Wei Huang, Gaowen Qu, et al. &#8220;Kallistatin enhances the phagocytic function of macrophages by decreasing the expression of CD24 in gastric cancer cells via the HIF-1\u03b1 signaling pathway.&#8221; bioRxiv. 05 Apr, 2024.<\/a><\/li>\n<li><a href=\"https:\/\/doi.org\/10.1038\/s43018-023-00715-8\" target=\"_blank\" rel=\"noopener\">3. Hao Zheng, Jinming Liu, et al. &#8220;Targeted activation of ferroptosis in colorectal cancer via LGR4 targeting overcomes acquired drug resistance.&#8221; Nat Cancer. 2024 Jan 30. PMID: 38291304<\/a><\/li>\n<li><a href=\"https:\/\/doi.org\/10.1038\/s41589-023-01528-7\" target=\"_blank\" rel=\"noopener\">4. Qianping Zhang, Tiantian Sun, et al. &#8220;PAFAH2 suppresses synchronized ferroptosis to ameliorate acute kidney injury.&#8221; Nat Chem Biol. 2024 Jan 29. PMID: 38287154<\/a><\/li>\n<li><a href=\"https:\/\/doi.org\/10.1016\/j.cej.2023.147466\" target=\"_blank\" rel=\"noopener\">5. Zhijing He, He Zhou, et al. &#8220;A bimetallic dual-targeting nanoplatform for combinational ferroptosis activation\/epigenetic regulation\/photothermal therapy against breast cancer and tumor microenvironment remodeling.&#8221; Chemical Engineering Journal Volume 479, 1 January 2024, 147466.<\/a><\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/37558749\" target=\"_blank\" rel=\"noopener\">6. Mingchao Mu, Qin Zhang, et al. &#8220;3-Bromopyruvate overcomes cetuximab resistance in human colorectal cancer cells by inducing autophagy-dependent ferroptosis.&#8221; Cancer Gene Ther. 2023 Aug 9. PMID: 37558749<\/a><\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/37272777\" target=\"_blank\" rel=\"noopener\">7. Yu Zhang, Xiyou Du, et al. &#8220;A Vanadium-Based Nanoplatform Synergizing Ferroptotic-like Therapy with Glucose Metabolism Intervention for Enhanced Cancer Cell Death and Antitumor Immunity.&#8221; ACS Nano. 2023 Jun 5. PMID: 37272777<\/a><\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/35504898\" target=\"_blank\" rel=\"noopener\">8. Fan Yu, Qianping Zhang, et al. &#8220;Dynamic O-GlcNAcylation coordinates ferritinophagy and mitophagy to activate ferroptosis.&#8221; Cell Discov. 2022 May 3;8(1):40. PMID: 35504898<\/a><\/li>\n<li><a>9. Binghua Liu, Weiyan Wang, et al. &#8220;Sodium iodate induces ferroptosis in human retinal pigment epithelium ARPE-19 cells.&#8221; Cell Death Dis. 2021 Mar 3;12(3):230.<\/a>\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/33658488\" target=\"_blank\" rel=\"noopener\">PMID: 33658488<\/a><\/li>\n<li><a>10. Junhong Zhang, Ni Wang, et al. &#8220;Oridonin induces ferroptosis by inhibiting gamma\u2010glutamyl cycle in TE1 cells.&#8221; Phytother Res 2020 Aug 31.<\/a>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32869425\" target=\"_blank\" rel=\"noopener\">PMID: 32869425<\/a><\/li>\n<li><a>11. Tianshu Wu, Xue Liang, et al. &#8220;Induction of ferroptosis in response to graphene quantum dots through mitochondrial oxidative stress in microglia.&#8221; Part Fibre Toxicol. 2020 Jul 11;17(1):30.<\/a>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32652997\" target=\"_blank\" rel=\"noopener\">PMID: 32652997<\/a><\/li>\n<\/ul>\n<p><img decoding=\"async\" src=\"https:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2025\/07\/3-%E7%94%B2%E7%A3%BA%E9%85%B8%E5%8E%BB%E9%90%B5%E8%83%BADeferoxamine-mesylate-CAS138-14-7-APExBIO%E8%B2%A8%E8%99%9FB6068.jpg\" \/><\/p>\n<p><img decoding=\"async\" src=\"https:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2025\/07\/4-%E7%94%B2%E7%A3%BA%E9%85%B8%E5%8E%BB%E9%90%B5%E8%83%BADeferoxamine-mesylate-CAS138-14-7-APExBIO%E8%B2%A8%E8%99%9FB6068.jpg\" \/><\/p>\n<p><img decoding=\"async\" src=\"https:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2025\/07\/5-%E7%94%B2%E7%A3%BA%E9%85%B8%E5%8E%BB%E9%90%B5%E8%83%BADeferoxamine-mesylate-CAS138-14-7-APExBIO%E8%B2%A8%E8%99%9FB6068.jpg\" \/><\/p>\n<\/div>\n<\/div>\n<div>\n<table>\n<tbody>\n<tr>\n<td>Physical Appearance<\/td>\n<td>A solid<\/td>\n<\/tr>\n<tr>\n<td>Storage<\/td>\n<td>Store at -20\u00b0C<\/td>\n<\/tr>\n<tr>\n<td>M.Wt<\/td>\n<td>656.79<\/td>\n<\/tr>\n<tr>\n<td>Cas No.<\/td>\n<td>138-14-7<\/td>\n<\/tr>\n<tr>\n<td>Formula<\/td>\n<td>C<sub>26<\/sub>H<sub>52<\/sub>N<sub>6<\/sub>O<sub>11<\/sub>S<\/td>\n<\/tr>\n<tr>\n<td>Solubility<\/td>\n<td>\u226565.7 mg\/mL in H2O; insoluble in EtOH; \u226529.8 mg\/mL in DMSO<\/td>\n<\/tr>\n<tr>\n<td>Chemical Name<\/td>\n<td>(Z)-4-((5-aminopentyl)(hydroxy)amino)-N-(5-((Z)-N,4-dihydroxy-4-((5-(N-hydroxyacetamido)pentyl)imino)butanamido)pentyl)-4-oxobutanimidic acid compound with methanesulfonic acid (1:1)<\/td>\n<\/tr>\n<tr>\n<td>SDF<\/td>\n<td><a href=\"https:\/\/www.apexbt.com\/downloader\/sdf\/B6068.sdf\">Download SDF<\/a><\/td>\n<\/tr>\n<tr>\n<td>Canonical SMILES<\/td>\n<td>CC(N(O)CCCCC\/N=C(O)\/CCC(N(O)CCCCC\/N=C(O)\/CCC(N(O)CCCCCN)=O)=O)=O.CS(O)(=O)=O<\/td>\n<\/tr>\n<tr>\n<td>Shipping Condition<\/td>\n<td>Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.<\/td>\n<\/tr>\n<tr>\n<td>General tips<\/td>\n<td>We do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div><\/div>\n<div id=\"cite\" class=\"tbar\"><a href=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2025\/07\/1-\u7532\u78fa\u9178\u53bb\u9435\u80faDeferoxamine-mesylate-CAS138-14-7-APExBIO\u8ca8\u865fB6068.pdf\"><img decoding=\"async\" loading=\"lazy\" class=\"alignnone\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/2023\/01\/%E7%B6%B2%E7%AB%99%E8%A6%8F%E6%A0%BC%E5%B0%8F%E5%9C%96_%E5%B7%A5%E4%BD%9C%E5%8D%80%E5%9F%9F-1_%E5%B7%A5%E4%BD%9C%E5%8D%80%E5%9F%9F-11-300x97.jpg\" alt=\"\u7db2\u7ad9\u898f\u683c\u5c0f\u5716_\u5de5\u4f5c\u5340\u57df 1_\u5de5\u4f5c\u5340\u57df 1\" width=\"149\" height=\"48\" \/><\/a><\/div>\n<div class=\"detail-table \">\n<div class=\"detail-box-cont\">\n<p><strong style=\"color: #800000;\"><span style=\"font-size: 12pt;\"><a style=\"color: #800000;\" href=\"http:\/\/www.apexbt.com\/\">APExBIO\u53f0\u7063\u4ee3\u7406\u5546<\/a><\/span><\/strong><\/p>\n<\/div>\n<\/div>\n<p><span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/www.apexbt.com\">https:\/\/www.apexbt.com<\/a><\/span><\/p>\n<p>APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002<\/p>\n<p><a href=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2025\/06\/APEXBIO-\u7522\u54c1\u6e05\u55ae2025.pdf\"><img decoding=\"async\" loading=\"lazy\" class=\"alignnone\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/2022\/12\/%E5%9E%8B%E9%8C%84%E4%B8%8B%E8%BC%89.gif\" alt=\"\u578b\u9304\u4e0b\u8f09\" width=\"150\" height=\"50\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5929\u7136\u7522\u54c1\u7cfb\u5217\u5546\u54c1-&gt;&gt;\u7532\u78fa\u9178\u53bb\u9435\u80fa(Deferoxamine mesylate) APExBIO  [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":47343,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5368],"tags":[6888],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/52031"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=52031"}],"version-history":[{"count":4,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/52031\/revisions"}],"predecessor-version":[{"id":53845,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/52031\/revisions\/53845"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/47343"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=52031"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=52031"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=52031"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}