{"id":51968,"date":"2025-07-03T15:53:56","date_gmt":"2025-07-03T07:53:56","guid":{"rendered":"https:\/\/biopioneer.com.tw\/?p=51968"},"modified":"2025-11-15T15:12:10","modified_gmt":"2025-11-15T07:12:10","slug":"%e6%b4%9b%e4%bc%90%e4%bb%96%e6%b1%80-lovastatin-cas75330-75-5-apexbio%e8%b2%a8%e8%99%9f-a4365","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=51968","title":{"rendered":"\u6d1b\u4f10\u4ed6\u6c40 (Lovastatin) | CAS#75330-75-5 APExBIO\u8ca8\u865f A4365"},"content":{"rendered":"

APExBIO HMG-CoA\u9084\u539f\u9176\u5546\u54c1->> Lovastatin<\/span>
\n<\/span><\/span><\/span><\/span><\/span><\/strong><\/span><\/p>\n

HMG-CoA reductase inhibitor<\/span><\/p>\n

APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5291(Small Molecule Inhibitors)\/\u6d3b\u5316\u5291(Activators)\u3001\u5316\u5408\u7269\u5eab( Compound Libraries)\u3001\u80dc\u80bd(Peptides)\u3001\u6aa2\u6e2c\u8a66\u5291\u76d2(Assay Kits)\u3001\u87a2\u5149\u6a19\u8a18(Fluorescent Label)\u3001\u9176(Enzymes)\u3001\u4fee\u98fe\u6838\u82f7\u9178(Modified Nucleotides)\u3001mRNA \u5408\u6210\u4ee5\u53ca\u5404\u7a2e\u5206\u5b50\u751f\u7269\u5b78\u5de5\u5177\u7684\u4f9b\u61c9\u5546\u3002APExBIO\u63d0\u4f9b\u5ee3\u6cdb\u7684\u7522\u54c1\u7dda\uff0c\u6db5\u84cb 20 \u591a\u500b\u4e0d\u540c\u7684\u7814\u7a76\u9818\u57df\uff0c\u4f8b\u5982\u764c\u75c7(cancer)\u3001\u514d\u75ab\u5b78(immunology)\u3001\u795e\u7d93\u79d1\u5b78(neurosciences)\u3001\u7d30\u80de\u51cb\u4ea1(apoptosis)\u548c\u8868\u89c0\u907a\u50b3\u5b78(epigenetics)\u7b49\u3002\u516c\u53f8\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u5fb7\u5dde\u4f11\u58eb\u9813USA (Houston, Texas)\uff0c\u81f4\u529b\u65bc\u670d\u52d9\u5168\u7403\u5ba2\u6236\u3002\u9ad8\u5ea6\u91cd\u8996\u7522\u54c1\u54c1\u8cea\u3002\u6240\u6709\u7522\u54c1\u5747\u9075\u5faa\u56b4\u683c\u7684\u751f\u7522\u6307\u5357\uff0c\u4e26\u9644\u6709\u5206\u6790\u8b49\u66f8\u3001HPLC\u3001\u8cea\u8b5c(Mass Spectrum)\u548cHMNR\u4ee5\u53ca\u9ad4\u5916\u9a57\u8b49(in vitro validation)\u3002 APExBIO\u7522\u54c1\u5df2\u88ab\u300aNature\u300b\u3001\u300aCell\u300b\u548c\u300aScience\u300b\u7b49\u773e\u591a\u9802\u7d1a\u540c\u884c\u8a55\u5be9\u671f\u520a\u5f15\u7528\u3002>>\u66f4\u591aAPExBio\u5546\u54c1<\/span><\/strong><\/em><\/span><\/a><\/p>\n

<\/p>\n

\u6d1b\u4f10\u4ed6\u6c40 (Lovastatin) | CAS#75330-75-5 APExBIO\u8ca8\u865f A4365<\/span><\/span><\/span><\/a><\/span><\/strong><\/span><\/p>\n

\u6d1b\u4f10\u4ed6\u6c40 (Lovastatin) \u662f3-\u7fa5\u57fa-3-\u7532\u57fa\u620a\u4e8c\u91af\u8f14\u9176A (3-hydroxy-3-methyl-glutaryl-CoA, HMG-CoA) \u9084\u539f\u9176\u7684\u6291\u5236\u5291\uff0c\u5728\u5927\u9f20\u809d\u7d30\u80de\u4e2d\u7684IC50\u503c\u70ba2.3 nmol\/L\uff0c\u5728\u4eba\u985e\u809d\u764c\u7d30\u80de\u682aHepG2 (human liver hepatocellular carcinoma cell line) \u4e2d\u7684IC50\u503c\u70ba5 nmol\/L [1]\u3002HMG-CoA\u9084\u539f\u9176\u8ca0\u8cac\u50ac\u5316\u81bd\u56fa\u9187\u751f\u7269\u5408\u6210\u4e2d\u7684\u901f\u7387\u9650\u5236\u6b65\u9a5f\u3002\u5b83\u50ac\u5316HMG-CoA\u8f49\u5316\u70ba\u7532\u7fa5\u620a\u9178\uff0c\u9019\u662f\u7d30\u80de\u4e2d\u81bd\u56fa\u9187\u751f\u6210\u7684\u7b2c\u4e8c\u6b65 [2]\u3002\u6d1b\u4f10\u4ed6\u6c40\u900f\u904e\u6291\u5236\u7532\u7fa5\u620a\u9178\u53ca\u5176\u4ee3\u8b1d\u7269\u7684\u751f\u6210\uff0c\u6291\u5236\u4e86\u591a\u7a2e\u7d30\u80de\u7684\u589e\u751f\u3002\u6291\u5236\u7532\u7fa5\u620a\u9178\u7684\u751f\u6210\u4e5f\u6291\u5236\u4e86\u7570\u620a\u4e8c\u70ef\u985e\u5316\u5408\u7269\u7684\u751f\u6210\uff0c\u800c\u7570\u620a\u4e8c\u70ef\u985e\u5316\u5408\u7269\u662f\u7d30\u80de\u589e\u6b96\u548c\u5176\u4ed6\u91cd\u8981\u7d30\u80de\u529f\u80fd\u6240\u5fc5\u9700\u7684\u3002\u7570\u620a\u4e8c\u70ef\u985e\u5316\u5408\u7269\u7684\u6e1b\u5c11\u7522\u751f\u4e86\u6709\u76ca\u7684\u591a\u6548\u6027\u6548\u61c9\u3002\u6d1b\u4f10\u4ed6\u6c40\u57281\u81f320 \u00b5M\u6fc3\u5ea6\u4e0b\u53ef\u5c0e\u81f4DNA\u5408\u6210\u6e1b\u5c11\u3002 1 \u00b5M \u6fc3\u5ea6\u4e0b\uff0c\u6d1b\u4f10\u4ed6\u6c40 (Lovastatin) \u53ef\u6291\u5236\u57f9\u990a\u4e2d\u7cfb\u819c\u7d30\u80de\u7684\u589e\u751f\u3002\u6d1b\u4f10\u4ed6\u6c40 (Lovastatin) (5 \u03bcM) \u4e5f\u5728 6 \u5c0f\u6642\u5f8c\u589e\u5f37\u4e86\u541e\u566c\u4f5c\u7528\uff08\u51cb\u4ea1\u7d30\u80de\u7684\u541e\u566c\u4f5c\u7528\uff09\u3002\u7136\u800c\uff0c24 \u5c0f\u6642\u5f8c\uff0c\u5176\u4f5c\u7528\u5448\u73fe\u5291\u91cf\u4f9d\u8cf4\u6027\uff0c\u5728 10 \u00b5M \u6fc3\u5ea6\u4e0b\u9054\u5230\u6700\u5927\u503c [3, 4, 5]\u3002\u5c0f\u9f20\u5728 30 \u5c0f\u6642\u5167\u63a5\u53d7\u4e09\u6b21\u6d1b\u4f10\u4ed6\u6c40 (Lovastatin) (10 mg\/kg) \u6cbb\u7642\uff0c\u7d50\u679c\u986f\u793a\u80ba\u6ce1\u5de8\u566c\u7d30\u80de\u7684\u541e\u566c\u4f5c\u7528\u589e\u5f37\u3002\u5728\u8c5a\u9f20\u50b7\u53e3\u8154\u6a21\u578b\u4e2d\uff0c\u6d1b\u4f10\u4ed6\u6c40 (Lovastatin) (5 \u00b5M\uff0c8 \u5929) \u4f7f\u8089\u82bd\u7d44\u7e54\u5f62\u6210\u6e1b<\/p>\n

<\/p>\n

Lovastatin<\/em>\u00a0Chemical Structure<\/p>\n

CAS No. :\u00a075330-75-5<\/p>\n\n\n\n\n\n\n\n\n\n\n\n
Storage<\/td>\nStore at -20\u00b0C<\/td>\n<\/tr>\n
M.Wt<\/td>\n404.54<\/td>\n<\/tr>\n
Cas No.<\/td>\n75330-75-5<\/td>\n<\/tr>\n
Formula<\/td>\nC24<\/sub>H36<\/sub>O5<\/sub><\/td>\n<\/tr>\n
Solubility<\/td>\ninsoluble in H2O; \u226518.6 mg\/mL in EtOH with ultrasonic; \u226520.2 mg\/mL in DMSO<\/td>\n<\/tr>\n
Chemical Name<\/td>\n[(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate<\/td>\n<\/tr>\n
SDF<\/td>\nDownload SDF<\/a><\/td>\n<\/tr>\n
Canonical SMILES<\/td>\nC[C@H]1C=CC2=C[C@H](C)C[C@H](OC([C@@H](C)CC)=O)[C@@H]2[C@H]1CC[C@H]3OC(C[C@H](O)C3)=O<\/td>\n<\/tr>\n
Shipping Condition<\/td>\nSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\"\u7db2\u7ad9\u898f\u683c\u5c0f\u5716_\u5de5\u4f5c\u5340\u57df<\/a><\/h4>\n

<\/p>\n

APExBIO\u53f0\u7063\u4ee3\u7406\u5546:\u00a0 <\/span><\/span><\/strong><\/span><\/a>https:\/\/www.apexbt.com\/<\/span><\/span><\/a><\/span><\/p>\n

APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002>>\u66f4\u591aAPExBio\u5546\u54c1<\/span><\/strong><\/em><\/span><\/a>
\n\"\u578b\u9304\u4e0b\u8f09\"<\/a><\/p>\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

APExBIO HMG-CoA\u9084\u539f\u9176\u5546\u54c1->> Lovastatin HMG-CoA reduct […]<\/p>\n","protected":false},"author":3,"featured_media":47343,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5368],"tags":[6898],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/51968"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=51968"}],"version-history":[{"count":3,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/51968\/revisions"}],"predecessor-version":[{"id":53695,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/51968\/revisions\/53695"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/47343"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=51968"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=51968"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=51968"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}