{"id":51952,"date":"2025-07-02T17:23:37","date_gmt":"2025-07-02T09:23:37","guid":{"rendered":"https:\/\/biopioneer.com.tw\/?p=51952"},"modified":"2025-11-15T16:49:12","modified_gmt":"2025-11-15T08:49:12","slug":"%e6%9b%b2%e6%a0%bc%e5%88%97%e9%85%ae-troglitazone-cas97322-87-7-apexbio%e8%b2%a8%e8%99%9fa3893","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=51952","title":{"rendered":"\u66f2\u683c\u5217\u916e (Troglitazone) | CAS#97322-87-7 APExBIO\u8ca8\u865fA3893"},"content":{"rendered":"

APExBIO \u9078\u64c7\u6027PPAR\u03b3\u6fc0\u52d5\u5291\u5546\u54c1->> Troglitazone<\/span>
\n<\/span><\/span><\/span><\/span><\/span><\/strong><\/span><\/p>\n

Selective PPAR\u03b3 agonist<\/span><\/p>\n

APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5291(Small Molecule Inhibitors)\/\u6d3b\u5316\u5291(Activators)\u3001\u5316\u5408\u7269\u5eab( Compound Libraries)\u3001\u80dc\u80bd(Peptides)\u3001\u6aa2\u6e2c\u8a66\u5291\u76d2(Assay Kits)\u3001\u87a2\u5149\u6a19\u8a18(Fluorescent Label)\u3001\u9176(Enzymes)\u3001\u4fee\u98fe\u6838\u82f7\u9178(Modified Nucleotides)\u3001mRNA \u5408\u6210\u4ee5\u53ca\u5404\u7a2e\u5206\u5b50\u751f\u7269\u5b78\u5de5\u5177\u7684\u4f9b\u61c9\u5546\u3002APExBIO\u63d0\u4f9b\u5ee3\u6cdb\u7684\u7522\u54c1\u7dda\uff0c\u6db5\u84cb 20 \u591a\u500b\u4e0d\u540c\u7684\u7814\u7a76\u9818\u57df\uff0c\u4f8b\u5982\u764c\u75c7(cancer)\u3001\u514d\u75ab\u5b78(immunology)\u3001\u795e\u7d93\u79d1\u5b78(neurosciences)\u3001\u7d30\u80de\u51cb\u4ea1(apoptosis)\u548c\u8868\u89c0\u907a\u50b3\u5b78(epigenetics)\u7b49\u3002\u516c\u53f8\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u5fb7\u5dde\u4f11\u58eb\u9813USA (Houston, Texas)\uff0c\u81f4\u529b\u65bc\u670d\u52d9\u5168\u7403\u5ba2\u6236\u3002\u9ad8\u5ea6\u91cd\u8996\u7522\u54c1\u54c1\u8cea\u3002\u6240\u6709\u7522\u54c1\u5747\u9075\u5faa\u56b4\u683c\u7684\u751f\u7522\u6307\u5357\uff0c\u4e26\u9644\u6709\u5206\u6790\u8b49\u66f8\u3001HPLC\u3001\u8cea\u8b5c(Mass Spectrum)\u548cHMNR\u4ee5\u53ca\u9ad4\u5916\u9a57\u8b49(in vitro validation)\u3002 APExBIO\u7522\u54c1\u5df2\u88ab\u300aNature\u300b\u3001\u300aCell\u300b\u548c\u300aScience\u300b\u7b49\u773e\u591a\u9802\u7d1a\u540c\u884c\u8a55\u5be9\u671f\u520a\u5f15\u7528\u3002>>\u66f4\u591aAPExBio\u5546\u54c1<\/span><\/strong><\/em><\/span><\/a><\/p>\n

<\/p>\n

\u66f2\u683c\u5217\u916e (Troglitazone) | CAS#97322-87-7 APExBIO\u8ca8\u865fA3893<\/span><\/span><\/span><\/a><\/span><\/strong><\/span><\/p>\n

\u904e\u6c27\u5316\u7269\u9176\u9ad4\u589e\u6b96\u6fc0\u6d3b\u53d7\u9ad4\u03b3 (Peroxisome proliferator-activated receptor gamma, PPAR\u03b3) \u6fc0\u52d5\u5291(agonists)\u548c PPAR\u03b3\/\u03b1 \u96d9\u6fc0\u52d5\u5291\u7528\u65bc\u6cbb\u7642\u7b2c 2 \u578b\u7cd6\u5c3f\u75c5(type 2 diabetes mellitus)\u3002\u66f2\u683c\u5217\u916e(Troglitazone)\u662f\u4e00\u7a2e\u5178\u578b\u7684\u81f4\u8089\u7624\u6027 PPAR\u03b3 \u6fc0\u52d5\u5291 (prototypical sarcomagenic PPARg agonist)\u3002\u9ad4\u5916\u5be6\u9a57\uff1a\u66f2\u683c\u5217\u916e(Troglitazone)PPAR\u03b3 \u914d\u9ad4\u8868\u73fe\u51fa\u5f37\u6548\u7684\u589e\u6b96\u6291\u88fd\u4f5c\u7528\uff0c\u4e26\u53ef\u8a98\u5c0e\u814e\u764c\u7d30\u80de\u51cb\u4ea1\uff0c\u63d0\u793a PPAR\u03b3 \u914d\u9ad4\u5c0d\u814e\u764c\u7d30\u80de\u5177\u6709\u6f5b\u5728\u7684\u6297\u816b\u7624\u4f5c\u7528 [1]\u3002\u9ad4\u5167\u5be6\u9a57\uff1a\u66f2\u683c\u5217\u916e(Troglitazone)\u5728\u81f4\u8089\u7624\u5291\u91cf (400 \u548c 800 mg\/kg) \u4e0b\u6cbb\u7642\u56db\u5468\u5f8c\uff0c\u53ef\u4fc3\u9032\u5c0f\u9f20\u68d5\u8272\u548c\u767d\u8272\u8102\u80aa\u7d44\u7e54\u53ca\u809d\u81df\u4e2d\u5167\u76ae\u7d30\u80de (EC) \u7684\u589e\u6b96 [2]\u3002\u81e8\u5e8a\u8a66\u9a57 (Clinical trial)\uff1a\u76ee\u524d\u5df2\u9032\u884c\u591a\u9805\u81e8\u5e8a\u8a66\u9a57\uff0c\u7814\u7a76\u66f2\u683c\u5217\u916e(Troglitazone)\u5728\u8102\u80aa\u8089\u7624(liposarcoma)\u548c\u7cd6\u5c3f\u75c5\u60a3\u8005\u4e2d\u7684\u7642\u6548\u3001\u5b89\u5168\u6027\u548c\u85e5\u7269\u52d5\u529b\u5b78 [3]\u3002<\/p>\n

<\/p>\n

roglitazone<\/em>\u00a0Chemical Structure<\/p>\n

CAS No. :\u00a097322-87-7<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Physical Appearance<\/td>\nA solid<\/td>\n<\/tr>\n
Storage<\/td>\nStore at -20\u00b0C<\/td>\n<\/tr>\n
M.Wt<\/td>\n441.54<\/td>\n<\/tr>\n
Cas No.<\/td>\n97322-87-7<\/td>\n<\/tr>\n
Formula<\/td>\nC24<\/sub>H27<\/sub>NO5<\/sub>S<\/td>\n<\/tr>\n
Synonyms<\/td>\nRezulin;CS-045;Noscal<\/td>\n<\/tr>\n
Solubility<\/td>\ninsoluble in H2O; \u226520.9 mg\/mL in DMSO; \u22653.34 mg\/mL in EtOH with gentle warming and ultrasonic<\/td>\n<\/tr>\n
Chemical Name<\/td>\n5-[[4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl)methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione<\/td>\n<\/tr>\n
SDF<\/td>\nDownload SDF<\/a><\/td>\n<\/tr>\n
Canonical SMILES<\/td>\nCC1=C(C(=C2CCC(OC2=C1C)(C)COC3=CC=C(C=C3)CC4C(=O)NC(=O)S4)C)O<\/td>\n<\/tr>\n
Shipping Condition<\/td>\nSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\"\u7db2\u7ad9\u898f\u683c\u5c0f\u5716_\u5de5\u4f5c\u5340\u57df<\/a><\/h4>\n

<\/p>\n

APExBIO\u53f0\u7063\u4ee3\u7406\u5546:\u00a0 <\/span><\/span><\/strong><\/span><\/a>https:\/\/www.apexbt.com\/<\/span><\/span><\/a><\/span><\/p>\n

APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002
\n\"\u578b\u9304\u4e0b\u8f09\"<\/a><\/p>\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

APExBIO \u9078\u64c7\u6027PPAR\u03b3\u6fc0\u52d5\u5291\u5546\u54c1->> Troglitazone Selective P […]<\/p>\n","protected":false},"author":3,"featured_media":47343,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5368],"tags":[6900],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/51952"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=51952"}],"version-history":[{"count":2,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/51952\/revisions"}],"predecessor-version":[{"id":53859,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/51952\/revisions\/53859"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/47343"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=51952"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=51952"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=51952"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}