{"id":51944,"date":"2025-07-02T14:52:47","date_gmt":"2025-07-02T06:52:47","guid":{"rendered":"https:\/\/biopioneer.com.tw\/?p=51944"},"modified":"2025-11-15T16:38:57","modified_gmt":"2025-11-15T08:38:57","slug":"%e4%b9%99%e9%86%af%e6%b0%a8%e5%9f%ba%e9%85%9aacetaminophen-paracetamol-cas-103-90-2apexbio%e8%b2%a8%e8%99%9f-b3532","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=51944","title":{"rendered":"\u4e59\u91af\u6c28\u57fa\u915a(acetaminophen\/ paracetamol) | CAS# 103-90-2APExBIO\u8ca8\u865f B3532"},"content":{"rendered":"

COX-2\u6291\u5236\u5291\u7cfb\u5217\u5546\u54c1->>\u4e59\u91af\u6c28\u57fa\u915a(acetaminophen\/ paracetamol)<\/span><\/span><\/span><\/span><\/strong><\/p>\n

\u00a0Synonyms: Paracetamol; 4-Acetamidophenol; 4′-Hydroxyacetanilide<\/span><\/p>\n

APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5291 (Small Molecule Inhibitors)\/\u6d3b\u5316\u5291(Activators)\u3001\u5316\u5408\u7269\u5eab( Compound Libraries)\u3001\u80dc\u80bd(Peptides)\u3001\u6aa2\u6e2c\u8a66\u5291\u76d2(Assay Kits)\u3001\u87a2\u5149\u6a19\u8a18(Fluorescent Label)\u3001\u9176(Enzymes)\u3001\u4fee\u98fe\u6838\u82f7\u9178(Modified Nucleotides)\u3001mRNA \u5408\u6210\u4ee5\u53ca\u5404\u7a2e\u5206\u5b50\u751f\u7269\u5b78\u5de5\u5177\u7684\u4f9b\u61c9\u5546\u3002APExBIO\u63d0\u4f9b\u5ee3\u6cdb\u7684\u7522\u54c1\u7dda\uff0c\u6db5\u84cb 20 \u591a\u500b\u4e0d\u540c\u7684\u7814\u7a76\u9818\u57df\uff0c\u4f8b\u5982\u764c\u75c7(cancer)\u3001\u514d\u75ab\u5b78(immunology)\u3001\u795e\u7d93\u79d1\u5b78(neurosciences)\u3001\u7d30\u80de\u51cb\u4ea1(apoptosis)\u548c\u8868\u89c0\u907a\u50b3\u5b78(epigenetics)\u7b49\u3002\u516c\u53f8\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u5fb7\u5dde\u4f11\u58eb\u9813USA (Houston, Texas)\uff0c\u81f4\u529b\u65bc\u670d\u52d9\u5168\u7403\u5ba2\u6236\u3002\u9ad8\u5ea6\u91cd\u8996\u7522\u54c1\u54c1\u8cea\u3002\u6240\u6709\u7522\u54c1\u5747\u9075\u5faa\u56b4\u683c\u7684\u751f\u7522\u6307\u5357\uff0c\u4e26\u9644\u6709\u5206\u6790\u8b49\u66f8\u3001HPLC\u3001\u8cea\u8b5c(Mass Spectrum)\u548cHMNR\u4ee5\u53ca\u9ad4\u5916\u9a57\u8b49(in vitro validation)\u3002 APExBIO\u7522\u54c1\u5df2\u88ab\u300aNature\u300b\u3001\u300aCell\u300b\u548c\u300aScience\u300b\u7b49\u773e\u591a\u9802\u7d1a\u540c\u884c\u8a55\u5be9\u671f\u520a\u5f15\u7528\u3002>>\u66f4\u591aAPExBio\u5546\u54c1<\/span><\/strong><\/em><\/span><\/a><\/p>\n

<\/p>\n

\u4e59\u91af\u6c28\u57fa\u915a(acetaminophen\/ paracetamol) | CAS# 103-90-2APExBIO\u8ca8\u865f B3532<\/a><\/span><\/p>\n

\u7522\u54c1\u4ecb\u7d39<\/span><\/strong><\/span><\/p>\n

\u4e59\u91af\u6c28\u57fa\u915a(acetaminophen\/ paracetamol)\u662f\u4e00\u7a2e\u9078\u64c7\u6027\u74b0\u6c27\u5408\u9176-2 (COX-2) \u6291\u5236\u5291\uff0cIC50 \u70ba 25.8 \u03bcM\uff0c\u662f\u4e00\u7a2e\u5ee3\u6cdb\u4f7f\u7528\u7684\u89e3\u71b1\u93ae\u75db\u85e5(antipyretic analgesic) [1]\u3002\u4e59\u91af\u6c28\u57fa\u915a(acetaminophen\/ paracetamol) (50 mM) \u986f\u8457\u964d\u4f4e\u7d30\u80de\u6d3b\u529b\u3002\u4f46\u4e59\u91af\u6c28\u57fa\u915a(acetaminophen\/ paracetamol)\u8207 HV110 \u5408\u4f75\u4f7f\u7528\u53ef\u986f\u8457\u63d0\u9ad8\u7d30\u80de\u6d3b\u529b[2]\u3002\u4e59\u91af\u6c28\u57fa\u915a(acetaminophen\/ paracetamol) (250 mg\/kg) \u53ef\u964d\u4f4e\u5c0f\u9f20\u9ad4\u5167\u7a40\u80f1\u7518\u80bd(glutathione)\u6c34\u5e73\u548c\u7a40\u80f1\u7518\u80bd\u904e\u6c27\u5316\u7269\u9176\u6d3b\u6027(glutathione peroxidase activity)\uff0c\u4e26\u8a98\u5c0e\u5c0f\u9f20\u539f\u4ee3\u809d\u7d30\u80de\u80a5\u5927\u7d30\u80de\u6b7b\u4ea1\u548c\u80a5\u5927\u3002\u6291\u5236\u5291\u9435\u6291\u7d20-1 (ferrostatin-1) \u53ef\u963b\u65b7\u6b64\u4f5c\u7528\u3002\u4e59\u91af\u6c28\u57fa\u915a(acetaminophen\/ paracetamol)\u5728\u52d5\u7269\u6a21\u578b\u4e2d\u5177\u6709\u93ae\u75db\u548c\u89e3\u71b1\u4f5c\u7528\u3002<\/p>\n

<\/p>\n

Acetaminophen<\/em>\u00a0Chemical Structure<\/p>\n

CAS No. :\u00a0103-90-2<\/p>\n

\"COA\u6587\u4ef6_\u5de5\u4f5c\u5340\u57df<\/a><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Physical Appearance<\/td>\nA solid<\/td>\n<\/tr>\n
Storage<\/td>\nStore at -20\u00b0C<\/td>\n<\/tr>\n
M.Wt<\/td>\n151.16<\/td>\n<\/tr>\n
Cas No.<\/td>\n103-90-2<\/td>\n<\/tr>\n
Formula<\/td>\nC8<\/sub>H9<\/sub>NO2<\/sub><\/td>\n<\/tr>\n
Solubility<\/td>\ninsoluble in H2O; \u226529.4 mg\/mL in EtOH; \u22657.56 mg\/mL in DMSO<\/td>\n<\/tr>\n
Chemical Name<\/td>\n(Z)-N-(4-hydroxyphenyl)acetimidic acid<\/td>\n<\/tr>\n
SDF<\/td>\nDownload SDF<\/a><\/td>\n<\/tr>\n
Canonical SMILES<\/td>\nC\/C(O)=N\/C1=CC=C(O)C=C1<\/td>\n<\/tr>\n
Shipping Condition<\/td>\nSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.<\/td>\n<\/tr>\n
General tips<\/td>\nWe do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
<\/div>\n
\n

<\/a><\/p>\n

1. Jing Chu, Yi Jiang, et al. “Acetaminophen alleviates ferroptosis in mice with sepsis-associated encephalopathy via the GPX4 pathway.” Hum Exp Toxicol. 2022 Jan-Dec;41:9603271221133547. PMID: 36214461<\/a><\/p>\n<\/div>\n

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APExBIO\u53f0\u7063\u4ee3\u7406\u5546<\/a><\/span><\/strong><\/p>\n<\/div>\n<\/div>\n

https:\/\/www.apexbt.com<\/a><\/span><\/p>\n

APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002<\/p>\n

\"\u578b\u9304\u4e0b\u8f09\"<\/a><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

COX-2\u6291\u5236\u5291\u7cfb\u5217\u5546\u54c1->>\u4e59\u91af\u6c28\u57fa\u915a(acetaminophen\/ paracetamol) […]<\/p>\n","protected":false},"author":3,"featured_media":47343,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5368],"tags":[6902],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/51944"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=51944"}],"version-history":[{"count":2,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/51944\/revisions"}],"predecessor-version":[{"id":53846,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/51944\/revisions\/53846"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/47343"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=51944"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=51944"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=51944"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}