{"id":51632,"date":"2025-06-26T13:46:48","date_gmt":"2025-06-26T05:46:48","guid":{"rendered":"https:\/\/biopioneer.com.tw\/?p=51632"},"modified":"2025-11-15T15:41:19","modified_gmt":"2025-11-15T07:41:19","slug":"2-%e8%84%ab%e6%b0%a7-d-%e8%91%a1%e8%90%84%e7%b3%96-2-deoxy-d-glucose-cas-154-17-6-apexbio%e8%b2%a8%e8%99%9fb1027","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=51632","title":{"rendered":"2-\u812b\u6c27-D-\u8461\u8404\u7cd6 (2-Deoxy-D-glucose) | CAS# 154-17-6 APExBIO\u8ca8\u865fB1027"},"content":{"rendered":"

APExBIO Technology LLC \u54c1\u724c<\/span>->> <\/span><\/span><\/span><\/span><\/span><\/strong>2-\u812b\u6c27-D-\u8461\u8404\u7cd6<\/span><\/span><\/span><\/span><\/span>\u00a0(2-Deoxy-D-glucose)<\/span><\/span><\/span><\/span><\/a><\/span><\/p>\n

APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5291(Small Molecule Inhibitors)\/\u6d3b\u5316\u5291(Activators)\u3001\u5316\u5408\u7269\u5eab( Compound Libraries)\u3001\u80dc\u80bd(Peptides)\u3001\u6aa2\u6e2c\u8a66\u5291\u76d2(Assay Kits)\u3001\u87a2\u5149\u6a19\u8a18(Fluorescent Label)\u3001\u9176(Enzymes)\u3001\u4fee\u98fe\u6838\u82f7\u9178(Modified Nucleotides)\u3001mRNA \u5408\u6210\u4ee5\u53ca\u5404\u7a2e\u5206\u5b50\u751f\u7269\u5b78\u5de5\u5177\u7684\u4f9b\u61c9\u5546\u3002APExBIO\u63d0\u4f9b\u5ee3\u6cdb\u7684\u7522\u54c1\u7dda\uff0c\u6db5\u84cb 20 \u591a\u500b\u4e0d\u540c\u7684\u7814\u7a76\u9818\u57df\uff0c\u4f8b\u5982\u764c\u75c7(cancer)\u3001\u514d\u75ab\u5b78(immunology)\u3001\u795e\u7d93\u79d1\u5b78(neurosciences)\u3001\u7d30\u80de\u51cb\u4ea1(apoptosis)\u548c\u8868\u89c0\u907a\u50b3\u5b78(epigenetics)\u7b49\u3002\u516c\u53f8\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u5fb7\u5dde\u4f11\u58eb\u9813USA (Houston, Texas)\uff0c\u81f4\u529b\u65bc\u670d\u52d9\u5168\u7403\u5ba2\u6236\u3002\u9ad8\u5ea6\u91cd\u8996\u7522\u54c1\u54c1\u8cea\u3002\u6240\u6709\u7522\u54c1\u5747\u9075\u5faa\u56b4\u683c\u7684\u751f\u7522\u6307\u5357\uff0c\u4e26\u9644\u6709\u5206\u6790\u8b49\u66f8\u3001HPLC\u3001\u8cea\u8b5c(Mass Spectrum)\u548cHMNR\u4ee5\u53ca\u9ad4\u5916\u9a57\u8b49(in vitro validation)\u3002 APExBIO\u7522\u54c1\u5df2\u88ab\u300aNature\u300b\u3001\u300aCell\u300b\u548c\u300aScience\u300b\u7b49\u773e\u591a\u9802\u7d1a\u540c\u884c\u8a55\u5be9\u671f\u520a\u5f15\u7528\u3002>>\u66f4\u591aAPExBio\u5546\u54c1<\/span><\/strong><\/em><\/span><\/a><\/p>\n

<\/p>\n

\u00a02-\u812b\u6c27-D-\u8461\u8404\u7cd6 (2-Deoxy-D-glucose)| CAS# 154-17-6 APExBIO\u8ca8\u865fB1027<\/span><\/span><\/span><\/span><\/a><\/span><\/strong><\/span><\/p>\n

Synonyms: TD139; GB0139<\/p>\n

<\/p>\n

2-\u812b\u6c27-D-\u8461\u8404\u7cd6 (2-Deoxy-D-glucose, 2DG)\uff0c\u8461\u8404\u7cd6\u985e\u4f3c\u7269( glucose analogue)\uff0c\u662f\u4e00\u7a2e\u7af6\u722d\u6027\u7cd6\u89e3\u6291\u5236\u5291 (competitive glycolytic inhibitor) [1] [2] [3]\u3002\u7d30\u80de\u6bd2\u6027\u8a66\u9a57(Cytotoxicity assays) \u986f\u793a\uff0c\u5728KIT\u967d\u6027\u80c3\u8178\u9053\u9593\u8cea\u7624(KIT-positive GIST cell lines, GIST)\u7d30\u80de\u682a\u4e2d\uff0c2DG\u7684IC50\u503c\u4ecb\u65bc0.5\u03bcM\uff08GIST882\u7d30\u80de\u682a\uff09\u548c2.5\u03bcM\uff08GIST430\u7d30\u80de\u682a\uff09\u4e4b\u9593[4]\u3002\u7cd6\u89e3\u4f5c\u7528(Glycolysis)\u662f\u4e00\u500b\u7522\u751fATP\u7684\u5b50\u7cfb\u7d71[5]\u3002\u5982\u679c2DG\/\u8461\u8404\u7cd6\u7684\u751f\u7406\u76f8\u95dc\u6bd4\u4f8b\u70ba0.8\uff0c\u5247\u5728\u542b\u670925 mmol\/L\u8461\u8404\u7cd6\u7684DMEM\u57f9\u990a\u57fa\u4e2d\u751f\u9577\u7684FaDu\u7d30\u80de\u7684\u8461\u8404\u7cd6\u4ee3\u8b1d\u5c07\u53d7\u5230\u6291\u5236\u3002\u8207\u672a\u8655\u7406\u7684\u5c0d\u7167\u7d30\u80de\u76f8\u6bd4\uff0c2-\u812b\u6c27-D-\u8461\u8404\u7cd6 (2-Deoxy-D-glucose, 2DG)\u8655\u7406\u5c0e\u81f4\u7e3d\u7a40\u80f1\u7518\u80bd\u542b\u91cf\u4e0b\u964d30%\u81f340%\uff0c\u7d30\u80de\u6b7b\u4ea132% [2]\u3002 2-DG\u4ee5\u6fc3\u5ea6\u4f9d\u8cf4\u6027\u65b9\u5f0f\u6291\u5236PEDV\u7684\u589e\u6b96\uff0c\u4e26\u5728Vero\u7d30\u80de\u4e2d\u8a98\u5c0e\u5167\u8cea\u7db2\u58d3\u529b\u3002 2-\u812b\u6c27-D-\u8461\u8404\u7cd6 (2-Deoxy-D-glucose, 2DG)\u8655\u7406\u5c0d\u75c5\u6bd2\u5165\u4fb5\u7121\u986f\u8457\u5f71\u97ff\u3002\u4f46\u9032\u4e00\u6b65\u7814\u7a76\u8868\u660e\uff0c2-\u812b\u6c27-D-\u8461\u8404\u7cd6 (2-Deoxy-D-glucose, 2DG)\u964d\u4f4e\u4e86\u75c5\u6bd2\u86cb\u767d\u7ffb\u8b6f\uff0c\u9019\u610f\u5473\u84572-\u812b\u6c27-D-\u8461\u8404\u7cd6 (2-Deoxy-D-glucose, 2DG)\u53ef\u80fd\u5728\u75c5\u6bd2\u611f\u67d3\u65e9\u671f\u5f71\u97ff\u75c5\u6bd2\u8907\u88fd\u3002\u6b64\u5916\uff0c2-\u812b\u6c27-D-\u8461\u8404\u7cd6 (2-Deoxy-D-glucose, 2DG)\u8655\u7406\u589e\u52a0\u4e86CD13\u7684\u8868\u9054\u91cf[6]\u30022-\u812b\u6c27-D-\u8461\u8404\u7cd6 (2-Deoxy-D-glucose, 2DG)\u53ef\u589e\u5f37\u963f\u9ef4\u7d20(adriamycin)\u548c\u7d2b\u6749\u9187(paclitaxel)\u5728\u4eba\u985e\u9aa8\u8089\u7624(osteosarcoma)\u548c\u975e\u5c0f\u7d30\u80de\u80ba\u764c(non-small cell lung cancers)\u4e2d\u7684\u9ad4\u5167\u7642\u6548\uff0c\u5ef6\u7de9\u816b\u7624\u751f\u9577\u4e26\u5ef6\u9577\u5b58\u6d3b\u671f[3]\u3002<\/p>\n

 <\/p>\n

<\/p>\n

2-Deoxy-D-glucose Chemical Structure<\/span><\/span><\/p>\n

CAS No. : 154-17-6<\/span><\/p>\n

<\/p>\n

<\/p>\n

<\/p>\n

<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Storage<\/td>\nStore at -20\u00b0C<\/td>\n<\/tr>\n
M.Wt<\/td>\n164.16<\/td>\n<\/tr>\n
Cas No.<\/td>\n154-17-6<\/td>\n<\/tr>\n
Formula<\/td>\nC6<\/sub>H12<\/sub>O5<\/sub><\/td>\n<\/tr>\n
Solubility<\/td>\n\u2265105 mg\/mL in H2O; \u22652.37 mg\/mL in EtOH with gentle warming and ultrasonic; \u22658.2 mg\/mL in DMSO<\/td>\n<\/tr>\n
Chemical Name<\/td>\n(4R,5S,6R)-6-(hydroxymethyl)tetrahydro-2H-pyran-2,4,5-triol<\/td>\n<\/tr>\n
SDF<\/td>\nDownload SDF<\/a><\/td>\n<\/tr>\n
Canonical SMILES<\/td>\n[H][C@]([C@](C1([H])[H])([H])O[H])([C@](C([H])([H])O[H])([H])OC1([H])O[H])O[H]<\/td>\n<\/tr>\n
Shipping Condition<\/td>\nSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.<\/td>\n<\/tr>\n
General tips<\/td>\nWe do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\"\u7db2\u7ad9\u898f\u683c\u5c0f\u5716_\u5de5\u4f5c\u5340\u57df<\/a><\/h4>\n

<\/p>\n

APExBIO\u53f0\u7063\u4ee3\u7406\u5546<\/span><\/strong><\/span><\/a><\/p>\n

https:\/\/www.apexbt.com\/<\/span><\/span><\/a><\/p>\n

APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002<\/p>\n

<\/p>\n\n\n\n\n\n\n\n\n\n\n
Apexbio\u00a0 (\u7522\u54c1\u8ca8\u865f)<\/td>\n\n

Apexbio<\/p>\n

\u7522\u54c1\u54c1\u9805<\/td>\n

\u53cd\u61c9\u6b21\u6578<\/td>\n\n

Apexbio<\/p>\n

\u7522\u54c1\u4ecb\u7d39 (\u6709\u9023\u7d50)<\/td>\n<\/tr>\n

K2249<\/a><\/td>\nMTT\u7d30\u80de\u589e\u6b96\u6aa2\u6e2c\u8a66\u5291\u76d2<\/a><\/td>\n500T\/2500T<\/td>\n\u64cd\u4f5c\u624b\u518a<\/span><\/a><\/td>\n<\/tr>\n
K2262<\/a><\/td>\n\u4e2d\u6027\u7d05\u8840\u7403\u589e\u6b96\u6aa2\u6e2c\u8a66\u5291\u76d2<\/a><\/td>\n500T<\/td>\n\u64cd\u4f5c\u624b\u518a<\/a><\/span><\/td>\n<\/tr>\n
K2265<\/a><\/td>\n\u6c2b\u904e\u6c27\u5316\u8102\u8cea (LPO) \u6aa2\u6e2c\u8a66\u5291\u76d2<\/a><\/td>\n100T<\/td>\n\u64cd\u4f5c\u624b\u518a<\/span><\/a><\/td>\n<\/tr>\n
K2245<\/a><\/td>\n\u5b54\u96c0\u77f3\u7da0\u78f7\u9178\u9e7d\u6e2c\u5b9a\u8a66\u5291\u76d2<\/a><\/td>\n2500T<\/td>\n\u64cd\u4f5c\u624b\u518a<\/a><\/span><\/td>\n<\/tr>\n
K2212<\/a><\/td>\n2-NBDG\u8461\u8404\u7cd6\u651d\u53d6\u6aa2\u6e2c\u8a66\u5291\u76d2<\/a><\/td>\n500T<\/td>\n\u64cd\u4f5c\u624b\u518a<\/a><\/span><\/td>\n<\/tr>\n
K2293<\/a><\/td>\nAnnexin V-APC Reagent<\/a><\/td>\n100T\/200T<\/td>\n\u64cd\u4f5c\u624b\u518a<\/a><\/span><\/td>\n<\/tr>\n
K4630<\/a><\/td>\nGSH \u548c GSSG \u6aa2\u6e2c\u8a66\u5291\u76d2<\/a><\/td>\n100T<\/td>\n\u64cd\u4f5c\u624b\u518a<\/a><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\"\u578b\u9304\u4e0b\u8f09\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

APExBIO Technology LLC \u54c1\u724c->> 2-\u812b\u6c27-D-\u8461\u8404\u7cd6\u00a0(2-Deoxy- […]<\/p>\n","protected":false},"author":3,"featured_media":47343,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5368],"tags":[6907],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/51632"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=51632"}],"version-history":[{"count":11,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/51632\/revisions"}],"predecessor-version":[{"id":53741,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/51632\/revisions\/53741"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/47343"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=51632"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=51632"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=51632"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}