{"id":51214,"date":"2025-05-21T17:49:02","date_gmt":"2025-05-21T09:49:02","guid":{"rendered":"https:\/\/biopioneer.com.tw\/?p=51214"},"modified":"2025-11-15T15:15:13","modified_gmt":"2025-11-15T07:15:13","slug":"actinomycin-d-apexbio%e8%b2%a8%e8%99%9f-a4448","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=51214","title":{"rendered":"Actinomycin D |\u00a0 APExBIO\u8ca8\u865f A4448"},"content":{"rendered":"<p><strong><span style=\"font-size: 12pt; color: #ff6600;\"><span style=\"font-size: 14pt;\"><span style=\"color: #800080;\"><span style=\"color: #ff9900; font-size: 14pt;\"><span style=\"color: #008000;\"><span style=\"color: #800080;\">APExBIO Technology LLC \u54c1\u724c <span style=\"color: #ff6600;\">RNA\u805a\u5408\u9176\u6291\u5236\u5291<\/span><\/span><\/span><\/span><span style=\"color: #ff6600;\">\u7cfb\u5217\u5546\u54c1-&gt;&gt;Actinomycin D<\/span><\/span><\/span><\/span><\/strong><\/p>\n<p>APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5291(Small Molecule Inhibitors)\/\u6d3b\u5316\u5291(Activators)\u3001\u5316\u5408\u7269\u5eab( Compound Libraries)\u3001\u80dc\u80bd(Peptides)\u3001\u6aa2\u6e2c\u8a66\u5291\u76d2(Assay Kits)\u3001\u87a2\u5149\u6a19\u8a18(Fluorescent Label)\u3001\u9176(Enzymes)\u3001\u4fee\u98fe\u6838\u82f7\u9178(Modified Nucleotides)\u3001mRNA \u5408\u6210\u4ee5\u53ca\u5404\u7a2e\u5206\u5b50\u751f\u7269\u5b78\u5de5\u5177\u7684\u4f9b\u61c9\u5546\u3002APExBIO\u63d0\u4f9b\u5ee3\u6cdb\u7684\u7522\u54c1\u7dda\uff0c\u6db5\u84cb 20 \u591a\u500b\u4e0d\u540c\u7684\u7814\u7a76\u9818\u57df\uff0c\u4f8b\u5982\u764c\u75c7(cancer)\u3001\u514d\u75ab\u5b78(immunology)\u3001\u795e\u7d93\u79d1\u5b78(neurosciences)\u3001\u7d30\u80de\u51cb\u4ea1(apoptosis)\u548c\u8868\u89c0\u907a\u50b3\u5b78(epigenetics)\u7b49\u3002\u516c\u53f8\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u5fb7\u5dde\u4f11\u58eb\u9813USA (Houston, Texas)\uff0c\u81f4\u529b\u65bc\u670d\u52d9\u5168\u7403\u5ba2\u6236\u3002\u9ad8\u5ea6\u91cd\u8996\u7522\u54c1\u54c1\u8cea\u3002\u6240\u6709\u7522\u54c1\u5747\u9075\u5faa\u56b4\u683c\u7684\u751f\u7522\u6307\u5357\uff0c\u4e26\u9644\u6709\u5206\u6790\u8b49\u66f8\u3001HPLC\u3001\u8cea\u8b5c(Mass Spectrum)\u548cHMNR\u4ee5\u53ca\u9ad4\u5916\u9a57\u8b49(in vitro validation)\u3002 APExBIO\u7522\u54c1\u5df2\u88ab\u300aNature\u300b\u3001\u300aCell\u300b\u548c\u300aScience\u300b\u7b49\u773e\u591a\u9802\u7d1a\u540c\u884c\u8a55\u5be9\u671f\u520a\u5f15\u7528\u3002<a href=\"https:\/\/biopioneer.com.tw\/?news=apexbio%e5%8f%b0%e7%81%a3%e4%bb%a3%e7%90%86%e5%95%86-brandagency%e4%bb%a3%e7%90%86%e5%93%81%e7%89%8c-apexbio-2\"><span style=\"color: #ff0000;\"><em><strong><span style=\"text-decoration: underline;\">&gt;&gt;\u66f4\u591aAPExBio\u5546\u54c1<\/span><\/strong><\/em><\/span><\/a><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"https:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2025\/06\/%E5%A4%AA%E9%BC%8E-APExBIO-Technology-LLC-%E5%93%81%E7%89%8C.png\" width=\"1099\" height=\"274\" \/><\/p>\n<p><span style=\"color: #33cccc;\"><a style=\"color: #33cccc;\" href=\"https:\/\/biopioneer.com.tw\/?p=51214&amp;preview=true\"><span style=\"font-size: 12pt;\"><strong>Actinomycin D |\u00a0 APExBIO\u8ca8\u865f A4448<\/strong><\/span><\/a><\/span><\/p>\n<p>RNA polymerase inhibitor<\/p>\n<p>IC50\uff1a\u653e\u7dda\u83cc\u7d20 D (Actinomycin D) \u8868\u73fe\u51fa\u6fc3\u5ea6\u4f9d\u8cf4\u6027 DNA \u4fee\u5fa9\u6d3b\u6027\u964d\u4f4e\uff0cIC50 \u70ba 0.42 \u03bcM [1]\u3002\u653e\u7dda\u83cc\u7d20 D (dactinomycin) \u662f\u653e\u7dda\u83cc\u7d20\u7684\u4e00\u7a2e\uff0c\u662f\u5f9e\u93c8\u9ef4\u83cc\u5c6c\u571f\u58e4\u7d30\u83cc\u5206\u96e2\u51fa\u4f86\u7684\u4e00\u985e\u591a\u80bd\u6297\u751f\u7d20\u3002\u653e\u7dda\u83cc\u7d20 D (Actinomycin D) \u4f5c\u70ba\u4e00\u7a2e\u8f03\u8001\u7684\u5316\u7642\u85e5\u7269(older chemotherapy)\u5df2\u7d93\u4f7f\u7528\u591a\u5e74\uff0c\u5b83\u8207\u96d9\u934a\u548c\u55ae\u93c8 DNA \u7d50\u5408\uff0c\u900f\u904e\u5728\u8f49\u9304\u8d77\u59cb\u8907\u5408\u7269\u8655\u7d50\u5408 DNA \u4e26\u963b\u6b62 RNA \u805a\u5408\u9176\u5ef6\u9577 RNA \u93c8\u4f86\u6291\u5236 DNA \u548c RNA \u7684\u5408\u6210\u3002\u9ad4\u5916\uff1a\u5148\u524d\u7684\u7814\u7a76\u65e8\u5728\u78ba\u5b9a\u653e\u7dda\u83cc\u7d20 D (Actinomycin D) \u5c0d\u539f\u4ee3\u57f9\u990a 24 \u5c0f\u6642\u671f\u9593\u5206\u96e2\u7684\u5927\u9f20\u8102\u80aa\u7d30\u80de\u91cb\u653e\u7626\u7d20(leptin)\u7684\u5f71\u97ff\u3002\u7d50\u679c\u8868\u660e\uff0c\u653e\u7dda\u83cc\u7d20 D (Actinomycin D) \u548c\u5730\u585e\u7c73\u677e\u5747\u53ef\u6e1b\u5c11 24 \u5c0f\u6642\u5b75\u80b2\u671f\u9593\u7626\u7d20 mRNA \u7684\u640d\u5931\u3002\u50c5\u9700 0.1 \u03bcM \u7684\u653e\u7dda\u83cc\u7d20 D (Actinomycin D) \u5373\u53ef\u5c0d\u7626\u7d20\u91cb\u653e\u548c\u7626\u7d20 mRNA \u7d2f\u7a4d\u7522\u751f\u6700\u5927\u5f71\u97ff\uff0c\u8a72\u6fc3\u5ea6\u5c0d 24 \u5c0f\u6642\u5b75\u80b2\u7d50\u675f\u6642\u8102\u80aa\u7d30\u80de\u7684 18S RNA \u542b\u91cf\u6c92\u6709\u986f\u8457\u5f71\u97ff\u3002\u8207 24 \u5c0f\u6642\u6642\u89c0\u5bdf\u5230\u7684\u7626\u7d20 mRNA \u640d\u5931\u6e1b\u5c11\u76f8\u53cd\uff0c\u5728 0.1 \u03bcM \u653e\u7dda\u83cc\u7d20 D (Actinomycin D) \u5b58\u5728\u7684\u60c5\u6cc1\u4e0b\uff0c3-\u78f7\u9178\u7518\u6cb9\u919b\u812b\u6c2b\u9176\u4fe1\u4f7f\u6838\u7cd6\u6838\u9178 (GAPDH mRNA) \u7684\u640d\u5931\u589e\u52a0\u3002\u9019\u4e9b\u7d50\u679c\u8b49\u660e\u4e86\u653e\u7dda\u83cc\u7d20 D (Actinomycin D) \u5c0d\u7626\u7d20\u91cb\u653e\u548c\u7626\u7d20 mRNA \u6c34\u5e73\u7684\u7368\u7279\u8abf\u7bc0 [2]\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/2023\/12\/citation-5_%E5%B7%A5%E4%BD%9C%E5%8D%80%E5%9F%9F-1.jpg\" width=\"297\" height=\"55\" \/><\/p>\n<p><img decoding=\"async\" src=\"https:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2025\/05\/1-Actinomycin-D-APExBIO%E8%B2%A8%E8%99%9F-A4448.jpg\" \/><\/p>\n<p><img decoding=\"async\" src=\"https:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2025\/05\/2-Actinomycin-D-APExBIO%E8%B2%A8%E8%99%9F-A4448.jpg\" \/><\/p>\n<p><img decoding=\"async\" src=\"https:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2025\/05\/3-Actinomycin-D-APExBIO%E8%B2%A8%E8%99%9F-A4448.jpg\" \/><\/p>\n<p><img decoding=\"async\" src=\"https:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2025\/05\/6-Actinomycin-D-APExBIO%E8%B2%A8%E8%99%9F-A4448.jpg\" \/><\/p>\n<p><img decoding=\"async\" src=\"https:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2025\/05\/4-Actinomycin-D-APExBIO%E8%B2%A8%E8%99%9F-A4448.jpg\" \/><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"https:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2025\/05\/7-Actinomycin-D-APExBIO%E8%B2%A8%E8%99%9F-A4448.jpg\" width=\"839\" height=\"634\" \/><\/p>\n<div id=\"cite\" class=\"tbar\">\n<h2><span style=\"font-size: 12pt;\">Product Citation<\/span><\/h2>\n<\/div>\n<div class=\"detail-table \">\n<div class=\"detail-box-cont\">\n<ul id=\"artul\">\n<li><a href=\"https:\/\/doi.org\/10.1038\/s41467-024-49315-9\" target=\"_blank\" rel=\"noopener\">1. Fei Xie, Bin Liu, et al. &#8220;Smooth muscle NF90 deficiency ameliorates diabetic atherosclerotic calcification in male mice via FBXW7-AGER1-AGEs axis.&#8221; Nat Commun. 2024 Jun 11;15(1):4985. PMID: 38862515<\/a><\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/38443362\" target=\"_blank\" rel=\"noopener\">2. Yajin Chen, et al. &#8220;CircNUP54 promotes hepatocellular carcinoma progression via facilitating HuR cytoplasmic export and stabilizing BIRC3 mRNA.&#8221; Cell Death Dis. 2024 Mar 5;15(3):191. PMID: 38443362<\/a><\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/38429265\" target=\"_blank\" rel=\"noopener\">3. Bingxi Lei, et al. &#8220;Depletion of the\u00a0N6-Methyladenosine (m6A) reader protein IGF2BP3 induces ferroptosis in glioma by modulating the expression of GPX4.&#8221; Cell Death Dis. 2024 Mar 1;15(3):181. PMID: 38429265<\/a><\/li>\n<li><a href=\"https:\/\/doi.org\/10.1093\/carcin\/bgae010\" target=\"_blank\" rel=\"noopener\">4. Yuanjian Shi, Zehao Pan, et al. &#8220;tRF-29-79 regulates lung adenocarcinoma progression through mediating glutamine transporter SLC1A5.&#8221; Carcinogenesis. 2024 Feb 15:bgae010. PMID: 38366384<\/a><\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/38093288\" target=\"_blank\" rel=\"noopener\">5. Zhenyan Miao, Jifei Li, et al. &#8220;Hsa_circ_0136666 stimulates gastric cancer progression and tumor immune escape by regulating the miR-375\/PRKDC Axis and PD-L1 phosphorylation.&#8221; Mol Cancer. 2023 Dec 13;22(1):205. PMID: 38093288<\/a><\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/38016952\" target=\"_blank\" rel=\"noopener\">6. Yiyi Ji, Weiwei Zhang, et al. &#8220;The ELAVL3\/MYCN positive feedback loop provides a therapeutic target for neuroendocrine prostate cancer.&#8221; Nat Commun. 2023 Nov 28;14(1):7794. PMID: 38016952<\/a><\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/37705750\" target=\"_blank\" rel=\"noopener\">7. Haopei Zhang, Qiuyue Chen, et al. &#8220;DDX24 Mutation Alters NPM1 Phase Behavior and Disrupts Nucleolar Homeostasis in Vascular Malformations.&#8221; Int J Biol Sci. 2023 Aug 6;19(13):4123-4138. PMID: 37705750<\/a><\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/37663284\" target=\"_blank\" rel=\"noopener\">8. Jin Fan, Mengqi Zhuang, et al. &#8220;RNA N6-methyladenosine reader IGF2BP3 promotes acute myeloid leukemia progression by controlling stabilization of EPOR mRNA.&#8221; PeerJ. 2023 Aug 30:11:e15706. PMID: 37663284<\/a><\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/37632352\" target=\"_blank\" rel=\"noopener\">9. Huihui Bai, Meina Jiang, et al. &#8220;Whole Blood-Derived circUSP10 Acts as a Diagnostic Biomarker in Patients With Early-Stage Non-Small-Cell Lung Cancer.&#8221; Cell Transplant. 2023 Jan-Dec;32:9636897231193066. PMID: 37632352<\/a><\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/37532687\" target=\"_blank\" rel=\"noopener\">10. Jianye Zhong, Abai Xu, et al. &#8220;Circ_0000235 targets MCT4 to promote glycolysis and progression of bladder cancer by sponging miR-330-5p.&#8221; Cell Death Discov. 2023 Aug 2;9(1):283. PMID: 37532687<\/a><\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/37499939\" target=\"_blank\" rel=\"noopener\">11. Jia-Jie Lin, Rui Chen, et al. &#8220;Hsa_circ_0001402 alleviates vascular neointimal hyperplasia through a miR-183-5p-dependent regulation of vascular smooth muscle cell proliferation, migration, and autophagy.&#8221; J Adv Res. 2023 Jul 25;S2090-1232(23)00201-1. PMID: 37499939<\/a><\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/37379216\" target=\"_blank\" rel=\"noopener\">12. Xiaoxiao Ouyang, Xueyun Wang, et al. &#8220;Bacterial effector restricts liquid-liquid phase separation of ZPR1 to antagonize host UPRER.&#8221; Cell Rep. 2023 Jul 25;42(7):112700. PMID: 37379216<\/a><\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/37171793\" target=\"_blank\" rel=\"noopener\">13. Xia Yang, Qiaorui Bai, et al. &#8220;m6A\u2010Dependent Modulation via IGF2BP3\/MCM5\/Notch Axis Promotes Partial EMT and LUAD Metastasis.&#8221; Adv Sci (Weinh). 2023 Jul;10(20):e2206744. PMID: 37171793<\/a><\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/36675257\" target=\"_blank\" rel=\"noopener\">14. Shi D, Liu X, et al. &#8220;Yth m6A RNA-Binding Protein 1 Regulates Osteogenesis of MC3T3-E1 Cells under Hypoxia via Translational Control of Thrombospondin-1.&#8221; Int J Mol Sci 2023 Jan 16;24(2) PMID: 36675257<\/a><\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/35538152\" target=\"_blank\" rel=\"noopener\">15. Jinrui Zhang, Ge Zhang, et al. &#8220;Loss of RBMS1 promotes anti-tumor immunity through enabling PD-L1 checkpoint blockade in triple-negative breast cancer.&#8221; Cell Death Differ. 2022 May 10. PMID: 35538152<\/a><\/li>\n<li><a href=\"https:\/\/doi.org\/10.1038\/s12276-022-00735-x\" target=\"_blank\" rel=\"noopener\">16. Nan Zhang , Yan Shen, et al. &#8220;The m6A reader IGF2BP3 promotes LIHC progression by enhancing MCM10 stability.&#8221; Exp Mol Med. 2022 Feb;54(2):194-205 PMID: 35217832<\/a><\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/34953860\" target=\"_blank\" rel=\"noopener\">17. Xin Lin, Liwen Zhou, et al. &#8220;RNA binding protein RBM28 can translocate from the nucleolus to the nucleoplasm to inhibit the transcriptional activity of p53.&#8221; J Biol Chem. 2021 Dec 22;101524. PMID: 34953860<\/a><\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/34819492\" target=\"_blank\" rel=\"noopener\">18. Ye Ding, Xiaobai Liu, et al. &#8220;Pseudogene RPL32P3 regulates the blood\u2013tumor barrier permeability via the YBX2\/HNF4G axis.&#8221; Cell Death Discov. 2021 Nov 24;7(1):367. PMID: 34819492<\/a><\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/34657574\" target=\"_blank\" rel=\"noopener\">19. Diefei Liang, Wei-Jye Lin, et al. &#8220;m6A reader YTHDC1 modulates autophagy by targeting SQSTM1 in diabetic skin.&#8221; Autophagy. 2021 Oct 17;1-20. PMID: 34657574<\/a><\/li>\n<li><a>20. Yi\u2011tian Chen, Dan Xiang, et al. &#8220;Upregulation of lncRNA NIFK-AS1 in hepatocellular carcinoma by m 6 A methylation promotes disease progression and sorafenib resistance.&#8221; Hum Cell. 2021 Nov;34(6):1800-1811.<\/a>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/34374933\" target=\"_blank\" rel=\"noopener\">PMID: 34374933<\/a><\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/34245303\" target=\"_blank\" rel=\"noopener\">21. Yiping Zhu, Fang Wu, et al. &#8220;A positive feedback regulatory loop involving the lncRNA PVT1 and HIF-1\u03b1 in pancreatic cancer.&#8221; J Mol Cell Biol. 2021 Dec 6;13(9):676-689. PMID: 34245303<\/a><\/li>\n<li><a>22. Yiming Xu, Dandan Lv, et al. &#8220;METTL3 Promotes Lung Adenocarcinoma Tumorigenesis and Inhibits Ferroptosis by Stabilizing SLC7A11 m6A Modification.&#8221; Research Square. rs-1085921\/v1.<\/a><\/li>\n<li><a>23. Wen Li , Shanshan Wang, et al. &#8220;CircHECTD1 Regulates Cell Proliferation and Migration by the miR-320-5p\/SLC2A1 Axis in Glioblastoma Multiform.&#8221; Front Oncol. 2021 May 17;11:666391.<\/a>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/34079759\" target=\"_blank\" rel=\"noopener\">PMID: 34079759<\/a><\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32880751\" target=\"_blank\" rel=\"noopener\">24. Duolan Naren, Tianyou Yan, et al. &#8220;High Wilms&#8217; tumor 1 associating protein expression predicts poor prognosis in acute myeloid leukemia and regulates m 6 A methylation of MYC mRNA.&#8221; J Cancer Res Clin Oncol. 2021 Jan;147(1):33-47. PMID: 32880751<\/a><\/li>\n<li><a>25. Dandan Zhang, Ni Ni, et al. &#8220;CircRNA-vgll3 promotes osteogenic differentiation of adipose-derived mesenchymal stem cells via modulating miRNA-dependent integrin \u03b15 expression.&#8221; Cell Death Differ 2020 Aug 19.<\/a>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32814879\" target=\"_blank\" rel=\"noopener\">PMID: 32814879<\/a><\/li>\n<li><a>26. Hongyu Yang, Qingxia Lin, et al. &#8220;LncRNA NR_030777 Alleviates Paraquat-induced Neurotoxicity by Regulating Zfp326 and Cpne5.&#8221; Toxicol Sci. 2020 Nov 1;178(1):173-188.<\/a>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32735315\" target=\"_blank\" rel=\"noopener\">PMID: 32382014<\/a><\/li>\n<li><a>27. Zhang R, Li SW, et al. &#8220;TRIM11 facilitates chemoresistance in nasopharyngeal carcinoma by activating the \u03b2-catenin\/ABCC9 axis via p62-selective autophagic degradation of Daple.&#8221; Oncogenesis. 2020;9(5):45.<\/a>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32735315\" target=\"_blank\" rel=\"noopener\">PMID: 32382014<\/a><\/li>\n<li><a>28. Dai J, Yang L, et al. &#8220;A Functional Synonymous Variant in PDGFRA Is Associated with Better Survival in Acral Melanoma.&#8221; J Cancer. 2020;11(10):2945-2956.<\/a>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32226509\" target=\"_blank\" rel=\"noopener\">PMID: 32226509<\/a><\/li>\n<li><a>29. Bahat A, Lahav O, et al. &#8220;Targeting Spt5-Pol II by Small-Molecule Inhibitors Uncouples Distinct Activities and Reveals Additional Regulatory Roles.&#8221; Mol Cell. 2019 Sep 25. pii: S1097-2765(19)30663-X.<\/a>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31564557\" target=\"_blank\" rel=\"noopener\">PMID: 31564557<\/a><\/li>\n<li><a>30. Luo Y, Teng X, et al. &#8220;CD146-HIF-1\u03b1 hypoxic reprogramming drives vascular remodeling and pulmonary arterial hypertension.&#8221; Nat Commun. 2019 Aug 7;10(1):3551.<\/a>\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31391533\" target=\"_blank\" rel=\"noopener\">PMID: 31391533<\/a><\/li>\n<li><a>31. Xiao Y, Pan J, et al. &#8220;LncRNA MALAT1 increases the stemness of gastric cancer cells via enhancing SOX2 mRNA stability.&#8221; FEBS Open Bio. 2019 Jul;9(7):1212-1222.<\/a>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31037832\" target=\"_blank\" rel=\"noopener\">PMID: 31037832<\/a><\/li>\n<li><a>32. Wu H, He Y, et al. &#8220;LncRNA THOR increases osteosarcoma cell stemness and migration by enhancing SOX9 mRNA stability.&#8221; FEBS Open Bio. 2019 Mar 20;9(4):781-790.<\/a>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30984551\" target=\"_blank\" rel=\"noopener\">PMID: 30984551<\/a><\/li>\n<li><a>33. Gong F, Dong D, et al. &#8220;Long non-coding RNA FENDRR attenuates the stemness of non-small cell lung cancer cells via decreasing multidrug resistance gene 1 (MDR1) expression through competitively binding with RNA binding protein HuR.&#8221; Eur J Pharmacol. 2019 Jun 15;853:345-352.<\/a>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30981768\" target=\"_blank\" rel=\"noopener\">PMID: 30981768<\/a><\/li>\n<li><a>34. Cao H, Yu D, et al. &#8220;Hypoxia destroys the microstructure of microtubules and causes dysfunction of endothelial cells via the PI3K\/Stathmin1 pathway.&#8221; Cell Biosci. 2019 Feb 18;9:20.<\/a>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30820314\" target=\"_blank\" rel=\"noopener\">PMID: 30820314<\/a><\/li>\n<li><a>35. Oladimeji PO, Wright WC, et al. &#8220;RNA interference screen identifies NAA10 as a regulator of PXR transcription.&#8221; Biochem Pharmacol. 2018 Dec 16;160:92-109.<\/a>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30566892\" target=\"_blank\" rel=\"noopener\">PMID: 30566892<\/a><\/li>\n<li><a>36. Bao L, Yuan L, et al. &#8220;A FUS-LATS1\/2 Axis Inhibits Hepatocellular Carcinoma Progression via Activating Hippo Pathway.&#8221; Cell Physiol Biochem. 2018;50(2):437-451.<\/a>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30308519\" target=\"_blank\" rel=\"noopener\">PMID: 30308519<\/a><\/li>\n<li><a>37. 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WEICHENG PAN, JINHUI PANG, et al. &#8220;RNA binding protein HuR promotes osteosarcoma cell progression via suppressing the miR-142-3p\/HMGA1 axis.&#8221; ONCOLOGY LETTERS. 2018 May 31.<\/a><\/li>\n<li><a>41. Wang X, Hu H, et al. &#8220;RNA binding protein Lin28B confers gastric cancer cells stemness via directly binding to NRP-1.&#8221; Biomed Pharmacother. 2018 May 19;104:383-389.<\/a>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29787985\" target=\"_blank\" rel=\"noopener\">PMID: 29787985<\/a><\/li>\n<li><a>42. Yang L, Zhang Y, et al. &#8220;RNPC1 inhibits non-small cell lung cancer progression via regulating miR-181a\/CASC2 axis.&#8221; Biotechnol Lett. 2017 Dec 29.<\/a>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29288351\" target=\"_blank\" rel=\"noopener\">PMID: 29288351<\/a><\/li>\n<li><a>43. Wang Z, Pang J, et al. &#8220;RNA binding protein Lin28A promotes osteocarcinoma cells progression by associating with the long noncoding RNA MALAT1.&#8221; Biotechnol Lett. 2017 Dec 4.<\/a>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29204769\" target=\"_blank\" rel=\"noopener\">PMID: 29204769<\/a><\/li>\n<li><a>44. Xu W, Gong F, et al. &#8220;RNA-binding protein Dnd1 inhibits epithelial-mesenchymal transition and cancer stem cell-related traits on hepatocellular carcinoma cells.&#8221; Biotechnol Lett. 2017 Jun 7.<\/a>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28593479\" target=\"_blank\" rel=\"noopener\">PMID: 28593479<\/a><\/li>\n<li><a>45. Zhang Z, Huang A, et al. &#8220;HuR promotes breast cancer cell proliferation and survival via binding to CDK3 mRNA.&#8221; Biomed Pharmacother. 2017 May 10;91:788-795.<\/a>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28501005\" target=\"_blank\" rel=\"noopener\">PMID: 28501005<\/a><\/li>\n<li><a>46. Xu CZ, Jiang C, et al. &#8220;A Feed-Forward Regulatory Loop between HuR and the Long Noncoding RNA HOTAIR Promotes Head and Neck Squamous Cell Carcinoma Progression and Metastasis.&#8221; Cell Physiol Biochem.2016;40(5):1039-1051.<\/a>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27941336\" target=\"_blank\" rel=\"noopener\">PMID: 27941336<\/a><\/li>\n<\/ul>\n<\/div>\n<\/div>\n<p><a href=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2025\/05\/Actinomycin-D-APExBIO\u8ca8\u865f-A4448.pdf\"><img decoding=\"async\" loading=\"lazy\" class=\"alignnone\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/2023\/01\/%E7%B6%B2%E7%AB%99%E8%A6%8F%E6%A0%BC%E5%B0%8F%E5%9C%96_%E5%B7%A5%E4%BD%9C%E5%8D%80%E5%9F%9F-1_%E5%B7%A5%E4%BD%9C%E5%8D%80%E5%9F%9F-11-300x97.jpg\" alt=\"\u7db2\u7ad9\u898f\u683c\u5c0f\u5716_\u5de5\u4f5c\u5340\u57df 1_\u5de5\u4f5c\u5340\u57df 1\" width=\"149\" height=\"48\" \/><\/a><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/2022\/12\/%E5%93%81%E7%89%8C%E7%B9%AA%E5%9C%96-Apexbio_%E5%B7%A5%E4%BD%9C%E5%8D%80%E5%9F%9F-1-300x300.jpg\" width=\"203\" height=\"225\" \/><\/p>\n<p><a href=\"http:\/\/www.apexbt.com\/\"><span style=\"font-size: 14pt; color: #ff6600;\"><strong><span style=\"color: #800080;\">APExBIO\u53f0\u7063\u4ee3\u7406\u5546<\/span><\/strong><\/span><\/a><\/p>\n<p><a href=\"https:\/\/www.apexbt.com\/\"><span style=\"color: #ff99cc;\"><span style=\"color: #ff6600;\">https:\/\/www.apexbt.com\/<\/span><\/span><\/a><\/p>\n<p>APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002<a href=\"https:\/\/biopioneer.com.tw\/?news=apexbio%e5%8f%b0%e7%81%a3%e4%bb%a3%e7%90%86%e5%95%86-brandagency%e4%bb%a3%e7%90%86%e5%93%81%e7%89%8c-apexbio-2\"><span style=\"color: #ff0000;\"><em><strong><span style=\"text-decoration: underline;\">&gt;&gt;\u66f4\u591aAPExBio\u5546\u54c1<\/span><\/strong><\/em><\/span><\/a><\/p>\n<p><img decoding=\"async\" src=\"https:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2025\/06\/2-%E5%A4%AA%E9%BC%8E-APExBIO-Technology-LLC-%E5%93%81%E7%89%8C.png\" \/><\/p>\n<table style=\"height: 208px;\" width=\"1044\">\n<tbody>\n<tr>\n<td width=\"61\">Apexbio\u00a0 (\u7522\u54c1\u8ca8\u865f)<\/td>\n<td width=\"253\">\n<p>Apexbio<\/p>\n<p>\u7522\u54c1\u54c1\u9805<\/td>\n<td width=\"102\">\u53cd\u61c9\u6b21\u6578<\/td>\n<td width=\"92\">\n<p>Apexbio<\/p>\n<p>\u7522\u54c1\u4ecb\u7d39 (\u6709\u9023\u7d50)<\/td>\n<\/tr>\n<tr>\n<td width=\"61\"><a href=\"https:\/\/biopioneer.com.tw\/?p=49226\">K2249<\/a><\/td>\n<td width=\"253\"><a href=\"https:\/\/biopioneer.com.tw\/?p=49226\">MTT\u7d30\u80de\u589e\u6b96\u6aa2\u6e2c\u8a66\u5291\u76d2<\/a><\/td>\n<td width=\"102\">500T\/2500T<\/td>\n<td width=\"92\"><a href=\"https:\/\/biopioneer.com.tw\/?p=49226\"><span style=\"color: #ff9900;\">\u64cd\u4f5c\u624b\u518a<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td width=\"61\"><a href=\"https:\/\/biopioneer.com.tw\/?p=49328&amp;preview=true\">K2262<\/a><\/td>\n<td width=\"253\"><a href=\"https:\/\/biopioneer.com.tw\/?p=49328&amp;preview=true\">\u4e2d\u6027\u7d05\u8840\u7403\u589e\u6b96\u6aa2\u6e2c\u8a66\u5291\u76d2<\/a><\/td>\n<td width=\"102\">500T<\/td>\n<td width=\"92\"><span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/biopioneer.com.tw\/?p=49328\">\u64cd\u4f5c\u624b\u518a<\/a><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"61\"><a href=\"https:\/\/biopioneer.com.tw\/?p=50678&amp;preview=true\">K2265<\/a><\/td>\n<td width=\"253\"><a href=\"https:\/\/biopioneer.com.tw\/?p=50678&amp;preview=true\">\u6c2b\u904e\u6c27\u5316\u8102\u8cea (LPO) \u6aa2\u6e2c\u8a66\u5291\u76d2<\/a><\/td>\n<td width=\"102\">100T<\/td>\n<td width=\"92\"><a href=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2025\/03\/1-\u6c2b\u904e\u6c27\u5316\u8102\u8cea-LPO-\u6aa2\u6e2c\u8a66\u5291\u76d2-Lipid-Hydroperoxide-LPO-Assay-Kit-APExBIO\u8ca8\u865f-K2265.pdf\"><span style=\"color: #ff9900;\">\u64cd\u4f5c\u624b\u518a<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td width=\"61\"><a href=\"https:\/\/biopioneer.com.tw\/?p=50897&amp;preview=true\">K2245<\/a><\/td>\n<td width=\"253\"><a href=\"https:\/\/biopioneer.com.tw\/?p=50897&amp;preview=true\">\u5b54\u96c0\u77f3\u7da0\u78f7\u9178\u9e7d\u6e2c\u5b9a\u8a66\u5291\u76d2<\/a><\/td>\n<td width=\"102\">2500T<\/td>\n<td width=\"92\"><span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2025\/03\/1-\u5b54\u96c0\u77f3\u7da0\u78f7\u9178\u9e7d\u6e2c\u5b9a\u8a66\u5291\u76d2-Malachite-Green-Phosphate-Assay-Kit-APExBIO\u8ca8\u865fK2245.pdf\">\u64cd\u4f5c\u624b\u518a<\/a><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"61\"><a href=\"https:\/\/biopioneer.com.tw\/?p=50976&amp;preview=true\">K2212<\/a><\/td>\n<td width=\"253\"><a href=\"https:\/\/biopioneer.com.tw\/?p=50976&amp;preview=true\">2-NBDG\u8461\u8404\u7cd6\u651d\u53d6\u6aa2\u6e2c\u8a66\u5291\u76d2<\/a><\/td>\n<td width=\"102\">500T<\/td>\n<td width=\"92\"><span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2025\/04\/1-2-NBDG\u8461\u8404\u7cd6\u651d\u53d6\u6aa2\u6e2c\u8a66\u5291\u76d2-2-NBDG-Glucose-Uptake-Assay-Kit-APExBIO\u8ca8\u865f-K2212.pdf\">\u64cd\u4f5c\u624b\u518a<\/a><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"61\"><a href=\"https:\/\/biopioneer.com.tw\/?p=51033\">K2293<\/a><\/td>\n<td width=\"253\"><a href=\"https:\/\/biopioneer.com.tw\/?p=51033&amp;preview=true\">Annexin V-APC Reagent<\/a><\/td>\n<td width=\"102\">100T\/200T<\/td>\n<td width=\"92\"><span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2025\/04\/1-Annexin-V-APC-Reagent-APExBIO\u8ca8\u865f-K2293.pdf\">\u64cd\u4f5c\u624b\u518a<\/a><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"61\"><a href=\"https:\/\/biopioneer.com.tw\/?p=51042&amp;preview=true\">K4630<\/a><\/td>\n<td width=\"253\"><a href=\"https:\/\/biopioneer.com.tw\/?p=51042&amp;preview=true\">GSH \u548c GSSG \u6aa2\u6e2c\u8a66\u5291\u76d2<\/a><\/td>\n<td width=\"102\">100T<\/td>\n<td width=\"92\"><span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2025\/04\/1-GSH-\u548c-GSSG-\u6aa2\u6e2c\u8a66\u5291\u76d2-GSH-and-GSSG-Assay-Kit-APExBIO\u8ca8\u865fK4630-1.pdf\">\u64cd\u4f5c\u624b\u518a<\/a><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><a href=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2025\/06\/APEXBIO-\u7522\u54c1\u6e05\u55ae2025.pdf\"><img decoding=\"async\" loading=\"lazy\" class=\"alignnone\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/2022\/12\/%E5%9E%8B%E9%8C%84%E4%B8%8B%E8%BC%89.gif\" alt=\"\u578b\u9304\u4e0b\u8f09\" width=\"150\" height=\"50\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>APExBIO Technology LLC \u54c1\u724c RNA\u805a\u5408\u9176\u6291\u5236\u5291\u7cfb\u5217\u5546\u54c1-&gt;&gt;Actinom [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":47343,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5368],"tags":[6917],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/51214"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=51214"}],"version-history":[{"count":8,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/51214\/revisions"}],"predecessor-version":[{"id":53698,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/51214\/revisions\/53698"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/47343"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=51214"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=51214"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=51214"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}