{"id":50431,"date":"2024-11-04T15:04:22","date_gmt":"2024-11-04T07:04:22","guid":{"rendered":"https:\/\/biopioneer.com.tw\/?p=50431"},"modified":"2025-11-15T16:39:22","modified_gmt":"2025-11-15T08:39:22","slug":"streptozocin-cas18883-66-4-apexbio-%e8%b2%a8%e8%99%9fa4457","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=50431","title":{"rendered":"Streptozocin | CAS#18883-66-4 APExBIO\u00a0 \u8ca8\u865fA4457"},"content":{"rendered":"

\u6297\u751f\u7d20\u548c\u6297\u816b\u7624\u5291\u7cfb\u5217\u5546\u54c1->>Streptozocin<\/span><\/span><\/span><\/span><\/strong><\/p>\n

APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5291(Small Molecule Inhibitors)\/\u6d3b\u5316\u5291(Activators)\u3001\u5316\u5408\u7269\u5eab( Compound Libraries)\u3001\u80dc\u80bd(Peptides)\u3001\u6aa2\u6e2c\u8a66\u5291\u76d2(Assay Kits)\u3001\u87a2\u5149\u6a19\u8a18(Fluorescent Label)\u3001\u9176(Enzymes)\u3001\u4fee\u98fe\u6838\u82f7\u9178(Modified Nucleotides)\u3001mRNA \u5408\u6210\u4ee5\u53ca\u5404\u7a2e\u5206\u5b50\u751f\u7269\u5b78\u5de5\u5177\u7684\u4f9b\u61c9\u5546\u3002APExBIO\u63d0\u4f9b\u5ee3\u6cdb\u7684\u7522\u54c1\u7dda\uff0c\u6db5\u84cb 20 \u591a\u500b\u4e0d\u540c\u7684\u7814\u7a76\u9818\u57df\uff0c\u4f8b\u5982\u764c\u75c7(cancer)\u3001\u514d\u75ab\u5b78(immunology)\u3001\u795e\u7d93\u79d1\u5b78(neurosciences)\u3001\u7d30\u80de\u51cb\u4ea1(apoptosis)\u548c\u8868\u89c0\u907a\u50b3\u5b78(epigenetics)\u7b49\u3002\u516c\u53f8\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u5fb7\u5dde\u4f11\u58eb\u9813USA (Houston, Texas)\uff0c\u81f4\u529b\u65bc\u670d\u52d9\u5168\u7403\u5ba2\u6236\u3002\u9ad8\u5ea6\u91cd\u8996\u7522\u54c1\u54c1\u8cea\u3002\u6240\u6709\u7522\u54c1\u5747\u9075\u5faa\u56b4\u683c\u7684\u751f\u7522\u6307\u5357\uff0c\u4e26\u9644\u6709\u5206\u6790\u8b49\u66f8\u3001HPLC\u3001\u8cea\u8b5c(Mass Spectrum)\u548cHMNR\u4ee5\u53ca\u9ad4\u5916\u9a57\u8b49(in vitro validation)\u3002 APExBIO\u7522\u54c1\u5df2\u88ab\u300aNature\u300b\u3001\u300aCell\u300b\u548c\u300aScience\u300b\u7b49\u773e\u591a\u9802\u7d1a\u540c\u884c\u8a55\u5be9\u671f\u520a\u5f15\u7528\u3002>>\u66f4\u591aAPExBio\u5546\u54c1<\/span><\/strong><\/em><\/span><\/a><\/p>\n

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Streptozocin| CAS#18883-66-4 APExBIO\u00a0 \u8ca8\u865fA4457<\/a><\/span><\/p>\n

Antibiotic and antitumor agent<\/p>\n

Antibiotic and antitumor agent. Alkylates DNA and induces diabetes mellitus via reduction of nicotinamide adenine dinucleotide in pancreatic \u03b2-cells\u00a0in vivo<\/em>.Streptozotocin (65 mg\/kg) resulted in rapid degranulation of \u03b2 cells, accumulation of glycogen in the proximal convoluted tubules of the kidney, as well as development of cataracts in 4 months after streptozotocin treatment. At a higher dose of 100 mg\/kg, streptozotocin produced lesions in the exocrine cells of the pancreas, and led to persistence of small, possibly secretory, granules in the Golgi zone of \u03b2 cells in diabetic rats. Streptozotocin is often used to induce diabetes mellitus in experimental animals.<\/p>\n

\u93c8\u8132\u4f50\u83cc\u7d20\uff0865 mg\/kg\uff09\u5c0e\u81f4\u03b2\u7d30\u80de\u5feb\u901f\u812b\u9846\u7c92\uff0c\u814e\u81df\u8fd1\u66f2\u5c0f\u7ba1\u809d\u91a3\u7a4d\u805a\uff0c\u4e26\u5728\u93c8\u8132\u4f50\u83cc\u7d20\u6cbb\u7642\u5f8c4\u500b\u6708\u5167\u51fa\u73fe\u767d\u5167\u969c\u3002\u5728 100 mg\/kg \u7684\u8f03\u9ad8\u5291\u91cf\u4e0b\uff0c\u93c8\u8132\u4f50\u83cc\u7d20\u6703\u5728\u80f0\u81df\u5916\u5206\u6ccc\u7d30\u80de\u7522\u751f\u640d\u50b7\uff0c\u4e26\u5c0e\u81f4\u7cd6\u5c3f\u75c5\u5927\u9f20\u7684 \u03b2 \u7d30\u80de\u9ad8\u723e\u57fa\u5340\u6301\u7e8c\u51fa\u73fe\u53ef\u80fd\u662f\u5206\u6ccc\u6027\u7684\u5c0f\u9846\u7c92\u3002\u93c8\u8132\u4f50\u83cc\u7d20\u5e38\u7528\u65bc\u8a98\u5c0e\u5be6\u9a57\u52d5\u7269\u7f79\u60a3\u7cd6\u5c3f\u75c5\u3002<\/p>\n

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