{"id":49901,"date":"2024-07-31T13:37:02","date_gmt":"2024-07-31T05:37:02","guid":{"rendered":"https:\/\/biopioneer.com.tw\/?p=49901"},"modified":"2025-06-30T12:42:45","modified_gmt":"2025-06-30T04:42:45","slug":"mg-132-proteasome-inhibitor-apexbio%e8%b2%a8%e8%99%9fa2585","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=49901","title":{"rendered":"MG-132 (Proteasome inhibitor) | APExBIO\u8ca8\u865fA2585"},"content":{"rendered":"

\u86cb\u767d\u9176\u9ad4\u6291\u5236\u5291<\/span>\u7cfb\u5217\u5546\u54c1->>MG-132<\/span><\/span><\/span><\/span><\/strong><\/p>\n

APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5291(Small Molecule Inhibitors)\/\u6d3b\u5316\u5291(Activators)\u3001\u5316\u5408\u7269\u5eab( Compound Libraries)\u3001\u80dc\u80bd(Peptides)\u3001\u6aa2\u6e2c\u8a66\u5291\u76d2(Assay Kits)\u3001\u87a2\u5149\u6a19\u8a18(Fluorescent Label)\u3001\u9176(Enzymes)\u3001\u4fee\u98fe\u6838\u82f7\u9178(Modified Nucleotides)\u3001mRNA \u5408\u6210\u4ee5\u53ca\u5404\u7a2e\u5206\u5b50\u751f\u7269\u5b78\u5de5\u5177\u7684\u4f9b\u61c9\u5546\u3002APExBIO\u63d0\u4f9b\u5ee3\u6cdb\u7684\u7522\u54c1\u7dda\uff0c\u6db5\u84cb 20 \u591a\u500b\u4e0d\u540c\u7684\u7814\u7a76\u9818\u57df\uff0c\u4f8b\u5982\u764c\u75c7(cancer)\u3001\u514d\u75ab\u5b78(immunology)\u3001\u795e\u7d93\u79d1\u5b78(neurosciences)\u3001\u7d30\u80de\u51cb\u4ea1(apoptosis)\u548c\u8868\u89c0\u907a\u50b3\u5b78(epigenetics)\u7b49\u3002\u516c\u53f8\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u5fb7\u5dde\u4f11\u58eb\u9813USA (Houston, Texas)\uff0c\u81f4\u529b\u65bc\u670d\u52d9\u5168\u7403\u5ba2\u6236\u3002\u9ad8\u5ea6\u91cd\u8996\u7522\u54c1\u54c1\u8cea\u3002\u6240\u6709\u7522\u54c1\u5747\u9075\u5faa\u56b4\u683c\u7684\u751f\u7522\u6307\u5357\uff0c\u4e26\u9644\u6709\u5206\u6790\u8b49\u66f8\u3001HPLC\u3001\u8cea\u8b5c(Mass Spectrum)\u548cHMNR\u4ee5\u53ca\u9ad4\u5916\u9a57\u8b49(in vitro validation)\u3002 APExBIO\u7522\u54c1\u5df2\u88ab\u300aNature\u300b\u3001\u300aCell\u300b\u548c\u300aScience\u300b\u7b49\u773e\u591a\u9802\u7d1a\u540c\u884c\u8a55\u5be9\u671f\u520a\u5f15\u7528\u3002<\/p>\n

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MG-132 (Proteasome inhibitor) | APExBIO\u8ca8\u865fA2585<\/span><\/a><\/span><\/p>\n

Proteasome inhibitor, Cell permeable, reversible<\/p>\n

\u7522\u54c1\u4ecb\u7d39<\/span><\/strong><\/span><\/p>\n

MG132\uff08carbobenzoxy-Leu-Leu-leucinal\/\u82ef\u7532\u6c27\u57fa-\u4eae\u6c28\u9178-\u4eae\u6c28\u9178-\u4eae\u6c28\u9178\uff09\u4f5c\u70ba\u4e00\u7a2e\u80bd\u919b(peptide aldehyde )\uff0c\u53ef\u6709\u6548\u963b\u65b7\u86cb\u767d\u9176\u9ad4\u8907\u5408\u7269(proteasome complex)\u7684\u86cb\u767d\u6c34\u89e3\u6d3b\u6027\u3002\u8b49\u660e\u53ef\u85c9\u7531\u5f62\u6210ROS \u8a98\u5c0e\u7d30\u80de\u51cb\u4ea1(apoptotic cell death)\u3002\u86cb\u767d\u9176\u9ad4\u6291\u5236\u5291(proteasome inhibitors)\u5c0e\u81f4\u7684 ROS \u5f62\u6210\u548c GSH \u6d88\u8017\u53ef\u80fd\u6703\u5c0e\u81f4\u7c92\u7dda\u9ad4\u529f\u80fd\u969c\u7919\u548c\u96a8\u5f8c\u7684\u7d30\u80de\u8272\u7d20 c \u91cb\u653e(cytochrome c)\uff0c\u5c0e\u81f4\u7d30\u80de\u6d3b\u529b\u55aa\u5931(cell viability) 1, 2<\/sup>\u3002MG132 \u5291\u91cf\u4f9d\u8cf4\u6027\u5730\u6291\u5236 A549 \u7d30\u80de\u7684\u751f\u9577\uff0cIC50 \u7d04\u70ba 20 \u00b5M\u3002 MG132 \u4e5f\u6e1b\u5c11\u4e86\u4eba\u985e\u5b50\u5bae\u9838 HeLa \u764c\u7d30\u80de( cervical HeLa cancer cells )\u7684\u751f\u9577\uff0cIC50 \u7d04\u70ba 5 \u00b5M\u3002\u4ee5 0.5 \u00b5M MG132 \u8655\u7406\u986f\u8457\u964d\u4f4e HeLa \u7d30\u80de\u7684\u751f\u9577\u4e26\u8a98\u5c0e\u7d30\u80de\u6b7b\u4ea1\u3002 MG132 \u7684\u7d30\u80de\u751f\u9577\u6291\u5236\u53d6\u6c7a\u65bc\u5176\u57f9\u990a\u5291\u91cf\u548c\u7d30\u80de\u985e\u578b3<\/sup>\u3002MG132 \u986f\u8457\u8a98\u5c0e\u7d30\u80de\u9031\u671f\u7684 G1 \u671f\u505c\u6eef\u3002\u5b83\u900f\u904e\u8a98\u5c0eG2\/M \u7d30\u80de\u9031\u671f\u963b\u6eef\u6291\u5236HT-29 \u7d50\u8178\u764c\u7d30\u80de\u7684\u751f\u9577\uff0c\u5c0e\u81f4MG-63 \u9aa8\u8089\u7624\u7d30\u80de\u963b\u6eef\u5728G2\/M \u671f5\uff0c\u5ef6\u9577MnCl2 \u8655\u7406\u7684A549 \u7d30\u80de\u4e2dG0\/G1 \u963b\u6eef\u7684\u6301\u7e8c\u6642\u9593\uff0c\u4e26\u8a98\u5c0e\u80c3\u764c\u7d30\u80deG1\u671f\u505c\u6eef6\u3002 MG132 \u5c0d\u6cdb\u7d20-\u86cb\u767d\u9176\u9ad4\u7cfb\u7d71\u7684\u5931\u8abf\u53ef\u5c0e\u81f4\u4e0d\u540c\u7684\u7d30\u80de\u9031\u671f\u968e\u6bb5\u505c\u6eef\uff0c\u9019\u53d6\u6c7a\u65bc\u4e0d\u540c\u7684\u764c\u7d30\u80de\u7cfb\u3002\u5305\u62ecMG132 \u5728\u5167\u7684\u86cb\u767d\u9176\u9ad4\u6291\u5236\u5291\u5df2\u88ab\u8b49\u660e\u53ef\u900f\u904eROS1\u30012\u30017 \u7684\u5f62\u6210\u8a98\u5c0e\u7d30\u80de\u51cb\u4ea1\u3002\u8207\u7d30\u80de\u51cb\u4ea1\u7684\u8b8a\u5316\u6709\u95dc\u3002<\/p>\n

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\"COA\u6587\u4ef6_\u5de5\u4f5c\u5340\u57df<\/a><\/p>\n

<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Storage<\/td>\nStore at -20\u00b0C
\nThe product is not stable in solution, please dissolve it immediately before use.<\/td>\n<\/tr>\n
M.Wt<\/td>\n475.6<\/td>\n<\/tr>\n
Cas No.<\/td>\n133407-82-6<\/td>\n<\/tr>\n
Formula<\/td>\nC26<\/sub>H41<\/sub>N3<\/sub>O5<\/sub><\/td>\n<\/tr>\n
Synonyms<\/td>\nMG132,Z-LLL-al,Z-Leu-Leu-Leu-CHO<\/td>\n<\/tr>\n
Solubility<\/td>\n\u226523.78 mg\/mL in DMSO; insoluble in H2O; \u226549.5 mg\/mL in EtOH<\/td>\n<\/tr>\n
Chemical Name<\/td>\nbenzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate<\/td>\n<\/tr>\n
SDF<\/td>\nDownload SDF<\/a><\/td>\n<\/tr>\n
Canonical SMILES<\/td>\nCC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1<\/td>\n<\/tr>\n
Shipping Condition<\/td>\nSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.<\/td>\n<\/tr>\n
General tips<\/td>\nWe do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
<\/div>\n

APExBIO\u53f0\u7063\u4ee3\u7406\u5546<\/a><\/span><\/strong><\/span><\/p>\n

https:\/\/www.apexbt.com<\/a><\/span><\/p>\n

APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002<\/p>\n

\"\u578b\u9304\u4e0b\u8f09\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

\u86cb\u767d\u9176\u9ad4\u6291\u5236\u5291\u7cfb\u5217\u5546\u54c1->>MG-132 APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148 […]<\/p>\n","protected":false},"author":3,"featured_media":47343,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5368],"tags":[6753],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/49901"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=49901"}],"version-history":[{"count":3,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/49901\/revisions"}],"predecessor-version":[{"id":51789,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/49901\/revisions\/51789"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/47343"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=49901"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=49901"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=49901"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}