{"id":49733,"date":"2024-07-01T13:24:18","date_gmt":"2024-07-01T05:24:18","guid":{"rendered":"https:\/\/biopioneer.com.tw\/?p=49733"},"modified":"2024-07-18T17:59:24","modified_gmt":"2024-07-18T09:59:24","slug":"%e9%85%aa%e8%83%ba%e9%85%b8%e6%bf%80%e9%85%b6%e6%8a%91%e5%88%b6%e5%8a%91%e5%ba%ab-discoveryprobe-tyrosine-kinase-inhibitor-library-apexbio-%e8%b2%a8%e8%99%9f-l1028","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=49733","title":{"rendered":"\u916a\u80fa\u9178\u6fc0\u9176\u6291\u5236\u5291\u5eab (DiscoveryProbe\u2122 Tyrosine Kinase Inhibitor Library) APExBIO\u00a0 \u8ca8\u865f L1028"},"content":{"rendered":"

DiscoveryProbe\u00a0 Drug Library<\/strong>\u7cfb\u5217\u7522\u54c1-Tyrosine Kinase Inhibitor Library<\/span><\/strong><\/span><\/p>\n

\u751f\u7269\u6d3b\u6027\u7be9\u9078\u5eab(Bioactive Screening Libraries)\u662f\u5373\u7528\u578b\u5316\u5b78\u5eab(chemical libraries)\uff0c\u7528\u65bc\u85e5\u7269\u767c\u73fe(drug discovery)\u3001\u5be6\u9a57\u5ba4\u85e5\u7269\u7be9\u9078(lab drug screening)\u3001\u85e5\u7269\u9776\u6a19\u8b58\u5225(drug target identification)\u548c\u5176\u4ed6\u88fd\u85e5\u76f8\u95dc\u61c9\u7528(pharmaceutical-related applications)\u3002\u5b83\u5011\u53ef\u7528\u65bc\u9ad8\u901a\u91cf\u7be9\u9078 (high-throughput screening , HTS) \u548c\u9ad8\u5167\u6db5\u7be9\u9078 (high-content screening , HCS)\u3002libraries\u5305\u542b\u8d85\u904e 5,000 \u500b\u5177\u6709\u7d93\u904e\u9a57\u8b49\u7684\u751f\u7269\u5b78(validated biological)\u548c\u85e5\u7406\u5b78\u6d3b\u6027(pharmacological activities)\u7684\u5c0f\u5206\u5b50(small molecules)\u3002\u9084\u8b49\u660e\u4e86\u5316\u5408\u7269\u7684\u6eb6\u89e3\u6027(solubility)\u3001\u7d14\u5ea6(purity)\u548c\u7a69\u5b9a\u6027(stability)\u3002\u9019\u4e9b\u5316\u5408\u7269\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u5df2\u901a\u904e\u6587\u737b(literature)\u3001\u81e8\u5e8a\u524d(preclinical)\u548c\u81e8\u5e8a\u7814\u7a76(clinical research)\u5f97\u5230\u8b49\u660e\uff0c\u8a31\u591a\u5316\u5408\u7269\u5df2\u7372\u5f97 FDA \u6279\u51c6(FDA-approved)\u3002<\/p>\n

\u7368\u7279\u5c0f\u5206\u5b50\u7684\u96c6\u5408\uff0c\u5305\u62ec\u6291\u5236\u5291(inhibitors)\u3001\u62ee\u6297\u5291(antagonists)\u548c\u6fc0\u52d5\u5291(agonists)\u3002\u9019\u4e9b\u5316\u5408\u7269\u5c08\u6ce8\u65bc\u6578\u767e\u500b\u76ee\u6a19\uff0c\u9019\u4e9b\u76ee\u6a19\u662f 20 \u591a\u500b\u4fe1\u865f\u901a\u8def(signaling pathways)\u6216\u7814\u7a76\u9818\u57df(research areas)\u7684\u4e00\u90e8\u5206\uff0c\u5305\u62ec DNA \u640d\u50b7(DNA Damage )\/DNA \u4fee\u5fa9(DNA Repair)\u3001\u7d30\u80de\u9031\u671f(Cell Cycle )\/\u6aa2\u67e5\u9ede(Checkpoint)\u3001JAK\/STAT \u4fe1\u865f\u901a\u8def(Signaling Pathway)\u3001MAPK \u4fe1\u865f\u901a\u8def(MAPK Signaling Pathway)\u3001GPCR\/G \u86cb\u767d(GPCR\/G protein)\u3001\u8840\u7ba1\u751f\u6210(Angiogenesis)\u3001\u514d\u75ab\u5b78\/\u708e\u75c7(Immunology\/Inflammation )\u3001\u5167\u5206\u6ccc\u5b78\u548c\u6fc0\u7d20(Endocrinology and Hormones)\u3001\u764c\u75c7\u751f\u7269\u5b78(Cancer Biology)\u3001\u65b0\u9673\u4ee3\u8b1d(Metabolism)\u3001\u5e79\u7d30\u80de(Stem Cell)\u7b49\u3002\u63d0\u4f9b\u5b9a\u5236\u7684\u751f\u7269\u6d3b\u6027\u7be9\u9078\u5eab(customized bioactive screening libraries)\uff0c\u60a8\u53ef\u4ee5\u5728\u5eab\u4e2d\u9078\u64c7\u6240\u9700\u7684\u5316\u5408\u7269\u3001\u5927\u5c0f\u3001\u6578\u91cf\u3001\u5f62\u5f0f\uff08\u7c89\u672b\u6216\u6eb6\u6db2\uff09\u548cplate\u3002<\/p>\n

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\u916a\u80fa\u9178\u6fc0\u9176\u6291\u5236\u5291\u5eab (DiscoveryProbe\u2122 Tyrosine Kinase Inhibitor Library) APExBIO\u00a0 \u8ca8\u865f L1028<\/span><\/strong><\/a><\/span><\/p>\n

\u916a\u80fa\u9178\u6fc0\u9176\u6291\u5236\u5291\u5eab (DiscoveryProbe\u2122 Tyrosine Kinase Inhibitor Library) \u7368\u7279\u7684 369 \u7a2e\u916a\u80fa\u9178\u6fc0\u9176\u6291\u5236\u5291(tyrosine kinase inhibitors)\u7cfb\u5217\uff0c\u7528\u65bc\u9ad8\u901a\u91cf\u7be9\u9078 ( high throughput screenin, HTS) \u548c\u9ad8\u5167\u6db5\u7be9\u9078 (high content screening, HCS)\u3002<\/p>\n

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Featured Products of the Library<\/span><\/h2>\n<\/div>\n
\n\n\n\n\n\n\n\n\n\n\n\n
Catalog No.<\/b><\/td>\nProduct Name<\/b><\/td>\nSummary<\/b><\/td>\nTargets<\/b><\/td>\nCAS Number<\/b><\/td>\n<\/tr>\n
A1389<\/td>\nWZ4002<\/td>\nMutant-selective EGFR inhibitor(L858R,T790M), irreversible and potent<\/td>\nEGFR<\/td>\n1213269-23-8<\/td>\n<\/tr>\n
A2838<\/td>\nOSI-930<\/td>\nInhibitor of Kit, KDR, Flt, CSF-1R, c-Raf and Lck<\/td>\nc-Kit<\/td>\n728033-96-3<\/td>\n<\/tr>\n
A3014<\/td>\nBGJ398<\/td>\nFGFR inhibitor ,potent and selective<\/td>\nFGFR<\/td>\n872511-34-7<\/td>\n<\/tr>\n
A5092<\/td>\nJNJ-38877605<\/td>\nC-Met inhibitor,ATP-competitive<\/td>\nc-MET<\/td>\n943540-75-8<\/td>\n<\/tr>\n
A8324<\/td>\nLDN-193189<\/td>\nALK inhibitor,potent and selective<\/td>\nSMAD<\/td>\n1062368-24-4<\/td>\n<\/tr>\n
A8329<\/td>\nR428<\/td>\nSelective Axl inhibitor<\/td>\nAxl<\/td>\n1037624-75-1<\/td>\n<\/tr>\n
A8528<\/td>\nTAK-285<\/td>\nHER2\/EGFR(HER1) inhibitor<\/td>\nHER2<\/td>\n871026-44-7<\/td>\n<\/tr>\n
A8696<\/td>\nFIIN-2<\/td>\nIrreversible inhibitor of FGFR<\/td>\nEGFR<\/td>\n1633044-56-0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

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\u00a0\"\"<\/strong><\/p>\n

\"\u578b\u9304\u4e0b\u8f09\"<\/a><\/p>\n

APExBIO\u53f0\u7063\u4ee3\u7406\u5546<\/a><\/p>\n

https:\/\/www.apexbt.com\/<\/a><\/p>\n

APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

DiscoveryProbe\u00a0 Drug Library\u7cfb\u5217\u7522\u54c1-Tyrosine Kinase Inhibi […]<\/p>\n","protected":false},"author":3,"featured_media":45049,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5368],"tags":[6630],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/49733"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=49733"}],"version-history":[{"count":3,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/49733\/revisions"}],"predecessor-version":[{"id":49737,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/49733\/revisions\/49737"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/45049"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=49733"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=49733"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=49733"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}