{"id":48095,"date":"2024-01-05T13:34:56","date_gmt":"2024-01-05T05:34:56","guid":{"rendered":"https:\/\/biopioneer.com.tw\/?p=48095"},"modified":"2024-01-08T10:25:10","modified_gmt":"2024-01-08T02:25:10","slug":"nintedanib-bibf-1120-cas656247-17-5apexbio%e8%b2%a8%e8%99%9f-a8252","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=48095","title":{"rendered":"Nintedanib (BIBF 1120) | CAS#656247-17-5APExBIO\u8ca8\u865f A8252"},"content":{"rendered":"<p><span style=\"color: #993366;\"><strong><span style=\"font-size: 14pt;\"><span style=\"color: #ff9900;\"><span style=\"color: #800080;\">VEGFR\/PDGFR\/FGFR inhibitor-<\/span><\/span><\/span><\/strong><\/span><span style=\"color: #ff9900;\"><strong><span style=\"font-size: 14pt;\">Nintedanib (BIBF 1120)<\/span><\/strong><\/span><span style=\"color: #993366;\"><strong><span style=\"font-size: 14pt;\"><span style=\"color: #ff9900;\"><span style=\"color: #800080;\"><br \/>\n<\/span><\/span><\/span><\/strong><\/span><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/2022\/09\/APExBIO_logo.jpg\" width=\"207\" height=\"42\" \/><\/p>\n<p><strong><span style=\"color: #33cccc;\"><a style=\"color: #33cccc;\" href=\"https:\/\/biopioneer.com.tw\/?p=47728\"><span style=\"font-size: 12pt;\">Nintedanib (BIBF 1120)| CAS#656247-17-5APExBIO\u8ca8\u865f A8252<\/span><\/a><\/span><\/strong><\/p>\n<p>SIRT1 activator Purity: 97.22%<\/p>\n<p>\u5c3c\u9054\u5c3c\u5e03(Nintedanib, BIBF 1120) \u662f\u4e00\u7a2e\u5432\u54da\u916e\u884d\u751f(indolinone-derived)\u7684\u53e3\u670d\u6d3b\u6027\u4e09\u91cd\u8840\u7ba1\u6fc0\u9176\u6291\u5236\u5291\uff0c\u8840\u7ba1\u5167\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4( vascular endothelial growth factor receptor, VEGFR)1-3\u3001\u7e96\u7dad\u6bcd\u7d30\u80de\u751f\u9577\u56e0\u5b50\u53d7\u9ad4(fibroblast growth factor receptor, FGFR)1-3\u548c\u8840\u5c0f\u677f\u884d\u751f\u751f\u9577\u56e0\u5b50\u53d7\u9ad4( platelet-derived growth factor receptor, PDGFR)\u03b1 \/\u03b21\u3002\u5b83\u900f\u904e\u963b\u65b7\u9019\u4e9b\u53d7\u9ad4\u4ecb\u5c0e\u7684\u4fe1\u865f\u901a\u8def\uff0c\u5728\u7d0d\u6469\u723e\u6fc3\u5ea6\uff08IC50\uff0c20-100 nmol\/L\uff09\u4e0b\u986f\u793a\u51fa\u6709\u6548\u7684\u6297\u8840\u7ba1\u751f\u6210\u6d3b\u6027\u3002\u5c3c\u9054\u5c3c\u5e03(Nintedanib, BIBF 1120) \u6b63\u8655\u65bc\u6cbb\u7642\u7279\u767c\u6027\u80ba\u7e96\u7dad\u5316( idiopathic pulmonary fibrosis)\u7684\u81e8\u5e8a\u958b\u767c\u968e\u6bb5\uff0c\u56e0\u70ba\u9019\u4e9b\u53d7\u9ad4\u5df2\u88ab\u8b49\u660e\u53ef\u80fd\u53c3\u8207\u80ba\u7e96\u7dad\u5316\u7684\u767c\u75c5\u6a5f\u5236\u3002\u4f5c\u70ba\u4e00\u7a2e\u65b0\u578b\u8840\u7ba1\u751f\u6210\u6291\u5236\u5291( novel angiogenesis inhibitor)\uff0c\u5b83\u4e5f\u5728\u4e0d\u540c\u7684\u764c\u75c7\u6a21\u578b\u4e2d\u5f97\u5230\u5ee3\u6cdb\u8a55\u4f30\uff0c\u4e26\u900f\u904e\u6291\u5236\u816b\u7624\u8840\u7ba1\u5f62\u6210\u8868\u73fe\u51fa\u986f\u8457\u7684\u6297\u816b\u7624\u6d3b\u6027\u3002<\/p>\n<p>\u70ba\u4e86\u9032\u4e00\u6b65\u8a55\u4f30\u5176\u5c0d\u591a\u7a2e\u816b\u7624\u7684\u6297\u816b\u7624\u4f5c\u7528\uff0c\u5c3c\u9054\u5c3c\u5e03(Nintedanib, BIBF 1120)\u76ee\u524d\u6b63\u5728\u9032\u5165\u591a\u9805\u81e8\u5e8a\u8a66\u9a57\uff0c\u5305\u62ec\u975e\u5c0f\u7d30\u80de\u80ba\u764c(non-small cell lung cancer)\u3001\u5375\u5de2\u764c(ovarian cancer)\u3001\u5927\u8178\u764c(colorectal cancer)\u3001\u809d\u7d30\u80de\u764c(hepatocellular carcinoma)\u548c\u8a31\u591a\u5176\u4ed6\u5be6\u9ad4\u7624 (solid tumors)\u3002\u6b64\u5916\uff0c\u5c3c\u9054\u5c3c\u5e03\u7642\u6cd5\u8207\u591a\u897f\u4ed6\u8cfd\u548c\u963f\u6cd5\u66ff\u5c3c\u7b49\u5176\u4ed6\u7642\u6cd5\u76f8\u7d50\u5408\u7684\u53ef\u80fd\u6027\u6b63\u5728\u4e0d\u540c\u7684\u816b\u7624\u6a21\u578b\u4e2d\u9032\u884c\u6e2c\u8a66\u3002\u60a3\u8005\u6700\u5e38\u898b\u7684\u85e5\u7269\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\u662f\u8179\u7009 (diarrhea)\u3001\u5641\u5fc3 (nausea)\u3001\u5614\u5410( vomiting)\u548c\u55dc\u7761(lethargy)\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"https:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2024\/01\/2-Nintedanib-BIBF-1120-CAS656247-17-5APExBIO%E8%B2%A8%E8%99%9F-A8252.jpg\" width=\"645\" height=\"497\" \/><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"https:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2024\/01\/3-Nintedanib-BIBF-1120-CAS656247-17-5APExBIO%E8%B2%A8%E8%99%9F-A8252.jpg\" width=\"637\" height=\"455\" \/><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"https:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2024\/01\/4-Nintedanib-BIBF-1120CAS656247-17-5APExBIO%E8%B2%A8%E8%99%9F-A8252.jpg\" width=\"643\" height=\"486\" \/><\/p>\n<div id=\"cite\" class=\"tbar\"><\/div>\n<div class=\"detail-table \">\n<div class=\"detail-box-cont\">\n<div id=\"cite\" class=\"tbar\">\n<h2><span style=\"color: #800000;\"><strong><span style=\"font-size: 12pt;\">Product Citation<\/span><\/strong><\/span><\/h2>\n<\/div>\n<div class=\"detail-table \">\n<div class=\"detail-box-cont\">\n<ul id=\"artul\">\n<li><a>1. da Silva RF, Banzato TP, et al. &#8220;Antiangiogenic therapy with Nintedanib affects hypoxia, angiogenesis and apoptosis in the ventral prostate of TRAMP animals.&#8221; Cell Tissue Res. 2019 Aug 31.<\/a>\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31473819\" target=\"_blank\" rel=\"noopener\">PMID:31473819<\/a><\/li>\n<li><a>2. Mateus PAM, Kido LA, et al. &#8220;Association of anti-inflammatory and antiangiogenic therapies negatively influences prostate cancer progression in TRAMP mice.&#8221; Prostate. 2018 Dec 25.<\/a>\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30585351\" target=\"_blank\" rel=\"noopener\">PMID:30585351<\/a><\/li>\n<li><a>3. Pangrazi EN, da Silva RF, et al. &#8220;Nintedanib treatment delays prostate dorsolateral lobe cancer progression in the TRAMP model: Contribution to the epithelial-stromal interaction balance.&#8221; Cell Biol Int. 2017 Oct 5.<\/a>\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28980742\" target=\"_blank\" rel=\"noopener\">PMID:28980742<\/a><\/li>\n<li><a>4. Janelle DeJong.&#8221;Determination of Anti-Fibrotic Effects of Possible Scar-Collagen Antagonists on TGF-\u03b21 Treated Dermal Fibroblasts.&#8221; 2017 Feb 1;7(2):203-217. eCollection 2017.<\/a><\/li>\n<\/ul>\n<\/div>\n<\/div>\n<table>\n<tbody>\n<tr>\n<td>Physical Appearance<\/td>\n<td>A solid<\/td>\n<\/tr>\n<tr>\n<td>Storage<\/td>\n<td>Store at -20\u00b0C<\/td>\n<\/tr>\n<tr>\n<td>M.Wt<\/td>\n<td>539.62<\/td>\n<\/tr>\n<tr>\n<td>Cas No.<\/td>\n<td>656247-17-5<\/td>\n<\/tr>\n<tr>\n<td>Formula<\/td>\n<td>C<sub>31<\/sub>H<sub>33<\/sub>N<sub>5<\/sub>O<sub>4<\/sub><\/td>\n<\/tr>\n<tr>\n<td>Synonyms<\/td>\n<td>Vargatef<\/td>\n<\/tr>\n<tr>\n<td>Solubility<\/td>\n<td>insoluble in H2O; insoluble in EtOH; \u22655.34 mg\/mL in DMSO<\/td>\n<\/tr>\n<tr>\n<td>Chemical Name<\/td>\n<td>methyl (3Z)-3-[[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]anilino]-phenylmethylidene]-2-oxo-1H-indole-6-carboxylate<\/td>\n<\/tr>\n<tr>\n<td>SDF<\/td>\n<td><a href=\"https:\/\/www.apexbt.com\/downloader\/sdf\/A8252.sdf\">Download SDF<\/a><\/td>\n<\/tr>\n<tr>\n<td>Canonical SMILES<\/td>\n<td>CN1CCN(CC1)CC(=O)N(C)C2=CC=C(C=C2)NC(=C3C4=C(C=C(C=C4)C(=O)OC)NC3=O)C5=CC=CC=C5<\/td>\n<\/tr>\n<tr>\n<td>Shipping Condition<\/td>\n<td>Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.<\/td>\n<\/tr>\n<tr>\n<td>General tips<\/td>\n<td>We do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><a href=\" http:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2024\/01\/1-Nintedanib-BIBF-1120-CAS656247-17-5APExBIO\u8ca8\u865f-A8252.pdf\"><img decoding=\"async\" loading=\"lazy\" class=\"alignnone\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/2023\/01\/%E7%B6%B2%E7%AB%99%E8%A6%8F%E6%A0%BC%E5%B0%8F%E5%9C%96_%E5%B7%A5%E4%BD%9C%E5%8D%80%E5%9F%9F-1_%E5%B7%A5%E4%BD%9C%E5%8D%80%E5%9F%9F-11-300x97.jpg\" alt=\"\u7db2\u7ad9\u898f\u683c\u5c0f\u5716_\u5de5\u4f5c\u5340\u57df 1_\u5de5\u4f5c\u5340\u57df 1\" width=\"149\" height=\"48\" \/><\/a><\/p>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/2022\/09\/APExBIO_logo.jpg\" width=\"370\" height=\"105\" \/><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #800000;\"><strong><span style=\"font-size: 12pt;\"><a style=\"color: #800000;\" href=\"http:\/\/www.apexbt.com\/\">APExBIO\u53f0\u7063\u4ee3\u7406\u5546<\/a><\/span><\/strong><\/span><\/p>\n<p><span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/www.apexbt.com\">https:\/\/www.apexbt.com<\/a><\/span><\/p>\n<p>APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002<\/p>\n<table width=\"725\">\n<tbody>\n<tr>\n<td width=\"68\">Catalog<\/td>\n<td width=\"100\">Sku<\/td>\n<td width=\"162\">Name<\/td>\n<td width=\"120\">CAS<\/td>\n<td width=\"275\">Short Summary<\/td>\n<\/tr>\n<tr>\n<td>A3821<\/td>\n<td>A3821-5<\/td>\n<td>SRT2104 (GSK2245840)<\/td>\n<td>1093403-33-8<\/td>\n<td>SIRT1 activator,selective<\/td>\n<\/tr>\n<tr>\n<td>A3839<\/td>\n<td>A3839-50<\/td>\n<td>SRT3190<\/td>\n<td>1204707-73-2<\/td>\n<td>CXCR2 ligand,SIRT1 activator<\/td>\n<\/tr>\n<tr>\n<td>A4180<\/td>\n<td>A4180-5<\/td>\n<td>SRT1720 HCl<\/td>\n<td>1001645-58-4<\/td>\n<td>SIRT1 activator<\/td>\n<\/tr>\n<tr>\n<td>A4182<\/td>\n<td>A4182-5.1<\/td>\n<td>Resveratrol<\/td>\n<td>501-36-0<\/td>\n<td>SIRT1 activator<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>VEGFR\/PDGFR\/FGFR inhibitor-Nintedanib (BIBF 1120) Ninte [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":47343,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5368],"tags":[6492],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/48095"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=48095"}],"version-history":[{"count":1,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/48095\/revisions"}],"predecessor-version":[{"id":48096,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/48095\/revisions\/48096"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/47343"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=48095"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=48095"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=48095"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}