{"id":47778,"date":"2023-12-11T18:03:08","date_gmt":"2023-12-11T10:03:08","guid":{"rendered":"https:\/\/biopioneer.com.tw\/?p=47778"},"modified":"2025-11-15T12:55:32","modified_gmt":"2025-11-15T04:55:32","slug":"ms436-cas1395084-25-9-apexbio%e8%b2%a8%e8%99%9f-b1012","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=47778","title":{"rendered":"MS436 | CAS#1395084-25-9 APExBIO\u8ca8\u865f B1012"},"content":{"rendered":"

\u9078\u64c7\u6027 BRD4 \u5c0f\u5206\u5b50\u6291\u5236\u5291 (BRD4 inhibitor)-MS436<\/span>
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MS436| CAS#1395084-25-9 APExBIO\u8ca8\u865f B1012<\/span><\/a><\/span><\/strong><\/p>\n

BRD4 inhibitor Purity: 98.50%<\/p>\n

MS436 \u662f\u4e00\u7a2e\u6709\u6548\u7684\u9078\u64c7\u6027 BRD4 \u5c0f\u5206\u5b50\u6291\u5236\u5291(selective small-molecule inhibitor)\uff0c\u5c0d BrD1 \u548c BrD2 \u7684 Ki \u503c\u5206\u5225\uff1c0.085\u03bcM \u548c 0.34\u03bcM [1]\u3002BRD4 \u5728\u57fa\u56e0\u8f49\u9304\u4e2d\u767c\u63ee\u4f5c\u7528\uff0c\u662f\u764c\u75c7(cancer)\u548c\u767c\u708e(inflammation)\u7684\u85e5\u7269\u6a19\u9776\u3002\u5b83\u6709\u5169\u500b\u6eb4\u7d50\u69cb\u57df(bromodomains)\u3002 MS436\u662f\u4e00\u7a2e\u91cd\u6c2e\u82ef\u5316\u5408\u7269\uff0c\u5b83\u662f\u6839\u64daSAR\u7814\u7a76\u800c\u8a2d\u8a08\u7684\uff0c\u5177\u6709\u66f4\u9ad8\u7684\u9078\u64c7\u6027\u3002\u9ad4\u5916\u87a2\u5149\u5404\u5411\u7570\u6027\u6e2c\u5b9a\u986f\u793a\uff0cMS436 \u5c0d BrD1 \u7684\u89aa\u548c\u529b\u6bd4 BrD2 \u9ad8\u7d04 10 \u500d\u3002 MS436 \u900f\u904e\u4e00\u7cfb\u5217\u6c34\u4ecb\u5c0e\u7684\u76f8\u4e92\u4f5c\u7528\u8207 BRD4 \u7d50\u5408\uff0c\u9019\u662f\u7d50\u5408\u89aa\u548c\u529b\u7684\u5206\u5b50\u57fa\u790e\u3002 MS436 \u4e5f\u5c0d CBP BrD \u5177\u6709\u6d3b\u6027\u3002\u5728 RAW264.7 \u7d30\u80de\u4e2d\uff0cMS436 \u53ef\u4ee5\u963b\u65b7 NF-\u03baB \u4ecb\u5c0e\u7684 NO \u7522\u751f\uff0c\u4e26\u963b\u65b7 LPS \u8a98\u5c0e\u7684\u4fc3\u767c\u708e\u7d30\u80de\u56e0\u5b50\u767d\u8840\u7403\u4ecb\u7d20 (proinflammatory cytokine interleukin , IL)-6 \u7684\u8868\u9054 [1]\u3002<\/p>\n

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Product Citation<\/span><\/strong><\/span><\/h2>\n

[1] Zhang G, Plotnikov AN, Rusinova E, Shen T, Morohashi K, Joshua J, Zeng L, Mujtaba S, Ohlmeyer M, Zhou MM. Structure-guided design of potent diazobenzene inhibitors for the BET bromodomains. J Med Chem. 2013 Nov 27;56(22):9251-64.<\/p>\n<\/div>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Physical Appearance<\/td>\nA solid<\/td>\n<\/tr>\n
Storage<\/td>\nStore at -20\u00b0C<\/td>\n<\/tr>\n
M.Wt<\/td>\n383.42<\/td>\n<\/tr>\n
Cas No.<\/td>\n1395084-25-9<\/td>\n<\/tr>\n
Formula<\/td>\nC18H17N5O3S<\/td>\n<\/tr>\n
Solubility<\/td>\ninsoluble in H2O; insoluble in EtOH; \u226519.15 mg\/mL in DMSO<\/td>\n<\/tr>\n
Chemical Name<\/td>\n4-[(2Z)-2-(2-amino-5-methyl-4-oxocyclohexa-2,5-dien-1-ylidene)hydrazinyl]-N-pyridin-2-ylbenzenesulfonamide<\/td>\n<\/tr>\n
SDF<\/td>\nDownload SDF<\/a><\/td>\n<\/tr>\n
Canonical SMILES<\/td>\nCC1=CC(=NNC2=CC=C(C=C2)S(=O)(=O)NC3=CC=CC=N3)C(=CC1=O)N<\/td>\n<\/tr>\n
Shipping Condition<\/td>\nSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.<\/td>\n<\/tr>\n
General tips<\/td>\nWe do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
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