{"id":47735,"date":"2023-12-08T12:20:51","date_gmt":"2023-12-08T04:20:51","guid":{"rendered":"https:\/\/biopioneer.com.tw\/?p=47735"},"modified":"2023-12-12T11:11:08","modified_gmt":"2023-12-12T03:11:08","slug":"srt2104-gsk2245840-cas1093403-33-8-apexbio%e8%b2%a8%e8%99%9f-a3821","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=47735","title":{"rendered":"SRT2104 (GSK2245840)| CAS#1093403-33-8 APExBIO\u8ca8\u865f A3821"},"content":{"rendered":"

SIRT1 \u6d3b\u5316\u5291(SIRT1 activator)-SRT2104 (GSK2245840)
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SRT2104 (GSK2245840)| CAS#1093403-33-8 APExBIO\u8ca8\u865f A3821<\/span><\/a><\/span><\/strong><\/p>\n

SIRT1 activator,selective Purity: 98.50%<\/p>\n

SRT2104 (GSK2245840) \u662f\u4e00\u7a2e\u9078\u64c7\u6027 SIRT1 \u6d3b\u5316\u5291\uff0c\u53c3\u8207\u80fd\u91cf\u7a69\u614b\u7684\u8abf\u7bc0\u3002 SIRT1\uff0c\u4e5f\u7a31\u70ba NAD \u4f9d\u8cf4\u6027\u53bb\u4e59\u91af\u5316\u9176 Sirtuin-1( NAD-dependent deacetylase sirtuin-1)\uff0c\u662f Sirtuin \u86cb\u767d\u5bb6\u65cf\u7684\u6210\u54e1\u3002\u9ad4\u5916\uff1a\u5728\u4ee5small hairpin RNA \u7a69\u5b9a\u8f49\u67d3\u4ee5\u6572\u9664 SIRT1 \u7684 C2C12 \u6210\u808c\u7d30\u80de\u4e2d\uff0cSRT2104 \u589e\u52a0\u4e86 AP \u6d3b\u6027\uff0c\u9019\u662f\u6210\u9aa8\u5206\u5316\u7684\u6a19\u8a18\u3002\u9019\u7a2e\u6548\u679c\u5b8c\u5168\u4f9d\u8cf4 SIRT1 \u7684\u8868\u9054 [1]\u3002\u9ad4\u5167\uff1a\u5728\u96c4\u6027C57BL\/6J \u5c0f\u9f20\u4e2d\uff0c\u7d66\u4e88SRT2104\uff08100 mg\/kg\uff0c\u53e3\u670d\uff09\u53ef\u5ef6\u9577\u6a19\u6e96\u98f2\u98df\u5c0f\u9f20\u7684\u5e73\u5747\u58fd\u547d\u548c\u6700\u5927\u58fd\u547d\uff0c\u4e26\u589e\u5f37\u9aa8\u7926\u7269\u8cea\u5bc6\u5ea6\u3001\u904b\u52d5\u5354\u8abf\u6027\u548c\u80f0\u5cf6\u7d20\u654f\u611f\u6027\uff0c\u4e26\u6e1b\u5c11\u767c\u708e\u3002\u77ed\u671f SRT2104 \u7d66\u85e5\u53ef\u5728\u840e\u7e2e\u5be6\u9a57\u6a21\u578b\u4e2d\u4fdd\u7559\u9aa8\u9abc\u548c\u808c\u8089\u8cea\u91cf [1]\u3002\u5728\u60a3\u6709\u4ea8\u4e01\u9813\u821e\u8e48\u75c7\u7684\u96c4\u6027 N171-82Q HD \u5c0f\u9f20\u4e2d\uff0cSRT2104\uff08\u542b 0.5% SRT2104 \u7684\u98f2\u98df\uff09\u6709\u6548\u7a7f\u900f\u8840\u8166\u969c\u58c1\uff0c\u6e1b\u8f15\u8166\u840e\u7e2e\uff0c\u6539\u5584\u904b\u52d5\u529f\u80fd\uff0c\u5ef6\u9577\u5b58\u6d3b\u671f [2]\u3002<\/p>\n

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Product Citation<\/span><\/strong><\/span><\/h2>\n

[1]. Mercken E M, Mitchell S J, Martin\u2010Montalvo A, et al. SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass[J]. Aging Cell, 2014, 13(5): 787-796.
\n[2]. Jiang M, Zheng J, Peng Q, et al. Sirtuin 1 activator SRT2104 protects Huntington’s disease mice[J]. Annals of clinical and translational neurology, 2014, 1(12): 1047-1052.<\/p>\n<\/div>\n\n\n\n\n\n\n\n\n\n\n\n\n
Storage<\/td>\nStore at -20\u00b0C<\/td>\n<\/tr>\n
M.Wt<\/td>\n516.64<\/td>\n<\/tr>\n
Cas No.<\/td>\n1093403-33-8<\/td>\n<\/tr>\n
Formula<\/td>\nC26<\/sub>H24<\/sub>N6<\/sub>O2<\/sub>S2<\/sub><\/td>\n<\/tr>\n
Solubility<\/td>\ninsoluble in H2O; insoluble in EtOH; \u22656.46 mg\/mL in DMSO with gentle warming<\/td>\n<\/tr>\n
Chemical Name<\/td>\n4-methyl-N-[2-[3-(morpholin-4-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]-2-pyridin-3-yl-1,3-thiazole-5-carboxamide<\/td>\n<\/tr>\n
SDF<\/td>\nDownload SDF<\/a><\/td>\n<\/tr>\n
Canonical SMILES<\/td>\nCC1=C(SC(=N1)C2=CN=CC=C2)C(=O)NC3=CC=CC=C3C4=CN5C(=CSC5=N4)CN6CCOCC6<\/td>\n<\/tr>\n
Shipping Condition<\/td>\nSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.<\/td>\n<\/tr>\n
General tips<\/td>\nWe do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
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