{"id":47728,"date":"2023-12-08T11:32:04","date_gmt":"2023-12-08T03:32:04","guid":{"rendered":"https:\/\/biopioneer.com.tw\/?p=47728"},"modified":"2023-12-12T11:10:56","modified_gmt":"2023-12-12T03:10:56","slug":"47728","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=47728","title":{"rendered":"SRT1720 HCl | CAS#1001645-58-4 APExBIO\u8ca8\u865f A4180"},"content":{"rendered":"<p><span style=\"color: #993366;\"><strong><span style=\"font-size: 14pt;\"><span style=\"color: #ff9900;\"><span style=\"color: #800080;\">SIRT1 \u6d3b\u5316\u5291(SIRT1 activator)-SRT1720<br \/>\n<\/span><\/span><\/span><\/strong><\/span><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/2022\/09\/APExBIO_logo.jpg\" width=\"207\" height=\"42\" \/><\/p>\n<p><strong><span style=\"color: #33cccc;\"><a style=\"color: #33cccc;\" href=\"https:\/\/biopioneer.com.tw\/?p=47728\"><span style=\"font-size: 12pt;\">SRT1720 HCl| CAS#1001645-58-4 APExBIO\u8ca8\u865f A4180<\/span><\/a><\/span><\/strong><\/p>\n<p>SIRT1 activator Purity: 99.52%<\/p>\n<p>SRT1720\u662f\u4e00\u7a2e\u5c0f\u5206\u5b50\u5316\u5408\u7269( small-molecule compound)\uff0c\u80fd\u5920\u5728\u9ad4\u5916\u6d3b\u5316sirtuin\u4e9e\u578bSIRT1\u3002 SRT1720 \u4f5c\u70ba SIRT1 \u6d3b\u5316\u5291(SIRT1 activator)\u7684\u6d3b\u6027\u6bd4\u767d\u85dc\u8606\u9187(resveratrol)\u66f4\u5f37\u3002\u5b83\u4ee5 Sirt1 \u548c PGC-1\u03b1 \u4f9d\u8cf4\u6027\u65b9\u5f0f\u5f71\u97ff\u7c92\u7dda\u9ad4\u547c\u5438(mitochondrial respiration)\u3002 SRT1720 \u5df2\u88ab\u8b49\u660e\u53ef\u4ee5\u589e\u5f37\u80f0\u5cf6\u7d20\u654f\u611f\u6027( insulin sensitivity)\u4e26\u6539\u5584\u7c92\u7dda\u9ad4\u80fd\u529b(mitochondrial capacity)\u548c\u6c27\u5316\u4ee3\u8b1d(oxidative metabolism)\u3002\u4f7f\u7528 SRT1720 \u6cbb\u7642\u591a\u767c\u6027\u9aa8\u9ad3\u7624 (multiple myeloma, MM) \u7d30\u80de\uff0c\u53ef\u6291\u5236\u5c0d\u50b3\u7d71\u7642\u6cd5\u548c\u787c\u66ff\u4f50\u7c73\u7642\u6cd5(bortezomib therapies )\u6297\u85e5\u6027\u7684 MM \u7d30\u80de\u7684\u751f\u9577\u4e26\u8a98\u5c0e\u7d30\u80de\u51cb\u4ea1\uff0c\u800c\u4e0d\u6703\u986f\u8457\u5f71\u97ff\u6b63\u5e38\u7d30\u80de\u7684\u6d3b\u529b\u3002 SRT1720 \u80fd\u5920\u589e\u5f37\u787c\u66ff\u4f50\u7c73(bortezomib)\u6216\u5730\u585e\u7c73\u9b06(dexamethasone)\u7684\u7d30\u80de\u6bd2\u6027\u6d3b\u6027(cytotoxic activity )\u3002 SRT1720\u7684\u6297MM\u6d3b\u6027\u8207\uff1a1) caspase-8\u3001caspase-9\u3001caspase-3\u3001\u805a(ADP)\u6838\u7cd6\u805a\u5408\u9176\u7684\u6d3b\u5316\uff1b 2\uff09\u6d3b\u6027\u6c27(reactive oxygen species)\u589e\u52a0\uff1b 3) \u8a98\u5c0e\u78f7\u9178\u5316\u5171\u6fdf\u5931\u8abf\u6bdb\u7d30\u8840\u7ba1\u64f4\u5f35\u7a81\u8b8a(phosphorylated ataxia telangiectasia mutated)\/\u6aa2\u67e5\u9ede\u6fc0\u91762\u8a0a\u865f\u50b3\u5c0e\uff1b 4) \u8840\u7ba1\u5167\u76ae\u751f\u9577\u56e0\u5b50\u8a98\u5c0e\u7684MM\u7d30\u80de\u9077\u79fb\u53ca\u76f8\u95dc\u8840\u7ba1\u65b0\u751f\u6e1b\u5c11\uff1b 5) \u6291\u5236\u6838\u56e0\u5b50-\u03baB\u3002SRT1720 \u662f\u4e00\u7a2e SIRT1 \u6d3b\u5316\u5291\u3002\u8207\u5c0d\u7167\u7d44\u76f8\u6bd4\uff0c\u5b83\u4f7f VEGF \u6fc3\u5ea6\u589e\u52a0\u4e86\u7d04 30%\uff0c\u8868\u660e SRT1720 \u53ef\u80fd\u4fc3\u9032\u816b\u7624\u7684\u8840\u7ba1\u751f\u6210(angiogenesis of tumors)\u3002SRT1720 \u4e26\u6c92\u6709\u986f\u8457\u5f71\u97ff\u539f\u767c\u816b\u7624\u7684\u5927\u5c0f\u548c\u91cd\u91cf\uff0c\u4f46\u4f7f\u80ba\u8f49\u79fb\u6025\u5287\u589e\u52a0\u7d04 150%\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"https:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2023\/12\/2-SRT1720-HCl-CAS1001645-58-4-APExBIO%E8%B2%A8%E8%99%9F-A4180.png\" width=\"447\" height=\"658\" \/><\/p>\n<p><img decoding=\"async\" src=\"https:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2023\/12\/3-SRT1720-HCl-CAS1001645-58-4-APExBIO%E8%B2%A8%E8%99%9F-A4180.jpg\" \/><\/p>\n<p><img decoding=\"async\" src=\"https:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2023\/12\/5-SRT1720-HCl-CAS1001645-58-4-APExBIO%E8%B2%A8%E8%99%9F-A4180.jpg\" \/><\/p>\n<p><img decoding=\"async\" src=\"https:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2023\/12\/4-SRT1720-HCl-CAS1001645-58-4-APExBIO%E8%B2%A8%E8%99%9F-A4180.jpg\" \/><\/p>\n<p><img decoding=\"async\" src=\"https:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2023\/12\/6-SRT1720-HCl-CAS1001645-58-4-APExBIO%E8%B2%A8%E8%99%9F-A4180.jpg\" \/><\/p>\n<p><img decoding=\"async\" src=\"https:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2023\/12\/7-SRT1720-HCl-CAS1001645-58-4-APExBIO%E8%B2%A8%E8%99%9F-A4180.jpg\" \/><\/p>\n<p><img decoding=\"async\" src=\"https:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2023\/12\/9-SRT1720-HCl-CAS1001645-58-4-APExBIO%E8%B2%A8%E8%99%9F-A4180.jpg\" \/><\/p>\n<div id=\"cite\" class=\"tbar\">\n<h2><span style=\"color: #800000;\"><strong><span style=\"font-size: 12pt;\">Product Citation<\/span><\/strong><\/span><\/h2>\n<\/div>\n<div class=\"detail-table \">\n<div class=\"detail-box-cont\">\n<ul id=\"artul\">\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/35594394\" target=\"_blank\" rel=\"noopener\">1. Jinan Elayyan, Idan Carmon, et al. &#8220;Lef1 ablation alleviates cartilage mineralization following posttraumatic osteoarthritis induction.&#8221; Proc Natl Acad Sci U S A. 2022 May 24;119(21):e2116855119. PMID: 35594394<\/a><\/li>\n<li><a>2. Xueyu Hu, Gangning Feng, et al. &#8220;The Protective Mechanism of SIRT1 on Cartilage Through Regulation of LEF-1.&#8221; Research Square. doi.org\/10.21203\/rs.3.rs-214497\/v1.<\/a><\/li>\n<li><a>3. Yangyang Li, Lei Wang, et al. &#8220;SIRT1 Mediates Neuropathic Pain Induced by Sciatic Nerve Chronic Constrictive Injury in the VTA-NAc Pathway.&#8221; Pain Res Manag 2020 Aug 18;2020:4245968.<\/a>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32922581\" target=\"_blank\" rel=\"noopener\">PMID: 32922581<\/a><\/li>\n<li><a>4. Li Y, Xi Y, et al. &#8220;Sirtuin 1 activation alleviates primary biliary cholangitis via the blocking of the NF-\u03baB signaling pathway.&#8221; Int Immunopharmacol. 2020;83:106386.<\/a>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32193100\" target=\"_blank\" rel=\"noopener\">PMID: 32193100<\/a><\/li>\n<li><a>5. Lin Y, Liu J, et al. &#8220;FADD Phosphorylation Modulates Blood Glucose Levels by Decreasing the Expression of Insulin-Degrading Enzyme.&#8221; Mol Cells. 2020;43(4):373-383.<\/a>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32191993\" target=\"_blank\" rel=\"noopener\">PMID: 32191993<\/a><\/li>\n<li><a>6. Gao P, Li L, et al. &#8220;Activation of Transient Receptor Potential Channel Vanilloid 4 by DPP-4 (Dipeptidyl Peptidase-4) Inhibitor Vildagliptin Protects Against Diabetic Endothelial Dysfunction.&#8221; Hypertension. 2019 Nov 18:HYPERTENSIONAHA11913778.<\/a>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31735085\" target=\"_blank\" rel=\"noopener\">PMID: 31735085<\/a><\/li>\n<\/ul>\n<table>\n<tbody>\n<tr>\n<td>Physical Appearance<\/td>\n<td>A solid<\/td>\n<\/tr>\n<tr>\n<td>Storage<\/td>\n<td>Store at -20\u00b0C<\/td>\n<\/tr>\n<tr>\n<td>M.Wt<\/td>\n<td>506.02<\/td>\n<\/tr>\n<tr>\n<td>Cas No.<\/td>\n<td>1001645-58-4<\/td>\n<\/tr>\n<tr>\n<td>Formula<\/td>\n<td>C<sub>25<\/sub>H<sub>23<\/sub>N<sub>7<\/sub>OS\u00b7HCl<\/td>\n<\/tr>\n<tr>\n<td>Synonyms<\/td>\n<td>SRT-1720,SRT 1720,SRT 1720 Hydrochloride<\/td>\n<\/tr>\n<tr>\n<td>Solubility<\/td>\n<td>\u226525.3 mg\/mL in DMSO; insoluble in EtOH; \u226515.37 mg\/mL in H2O with gentle warming and ultrasonic<\/td>\n<\/tr>\n<tr>\n<td>Chemical Name<\/td>\n<td>N-[2-[3-(piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]quinoxaline-2-carboxamide;hydrochloride<\/td>\n<\/tr>\n<tr>\n<td>SDF<\/td>\n<td><a href=\"https:\/\/www.apexbt.com\/downloader\/sdf\/A4180.sdf\">Download SDF<\/a><\/td>\n<\/tr>\n<tr>\n<td>Canonical SMILES<\/td>\n<td>C1CN(CCN1)CC2=CSC3=NC(=CN23)C4=CC=CC=C4NC(=O)C5=NC6=CC=CC=C6N=C5.Cl<\/td>\n<\/tr>\n<tr>\n<td>Shipping Condition<\/td>\n<td>Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.<\/td>\n<\/tr>\n<tr>\n<td>General tips<\/td>\n<td>We do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><a href=\" http:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2023\/12\/1-SRT1720-HCl-CAS1001645-58-4-APExBIO\u8ca8\u865f-A4180.pdf\"><img decoding=\"async\" loading=\"lazy\" class=\"alignnone\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/2023\/01\/%E7%B6%B2%E7%AB%99%E8%A6%8F%E6%A0%BC%E5%B0%8F%E5%9C%96_%E5%B7%A5%E4%BD%9C%E5%8D%80%E5%9F%9F-1_%E5%B7%A5%E4%BD%9C%E5%8D%80%E5%9F%9F-11-300x97.jpg\" alt=\"\u7db2\u7ad9\u898f\u683c\u5c0f\u5716_\u5de5\u4f5c\u5340\u57df 1_\u5de5\u4f5c\u5340\u57df 1\" width=\"149\" height=\"48\" \/><\/a><\/p>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/2022\/09\/APExBIO_logo.jpg\" width=\"370\" height=\"105\" \/><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #800000;\"><strong><span style=\"font-size: 12pt;\"><a style=\"color: #800000;\" href=\"http:\/\/www.apexbt.com\/\">APExBIO\u53f0\u7063\u4ee3\u7406\u5546<\/a><\/span><\/strong><\/span><\/p>\n<p><span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/www.apexbt.com\">https:\/\/www.apexbt.com<\/a><\/span><\/p>\n<p>APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002<\/p>\n<table width=\"725\">\n<tbody>\n<tr>\n<td width=\"68\">Catalog<\/td>\n<td width=\"100\">Sku<\/td>\n<td width=\"162\">Name<\/td>\n<td width=\"120\">CAS<\/td>\n<td width=\"275\">Short Summary<\/td>\n<\/tr>\n<tr>\n<td>A3821<\/td>\n<td>A3821-5<\/td>\n<td>SRT2104 (GSK2245840)<\/td>\n<td>1093403-33-8<\/td>\n<td>SIRT1 activator,selective<\/td>\n<\/tr>\n<tr>\n<td>A3839<\/td>\n<td>A3839-50<\/td>\n<td>SRT3190<\/td>\n<td>1204707-73-2<\/td>\n<td>CXCR2 ligand,SIRT1 activator<\/td>\n<\/tr>\n<tr>\n<td>A4180<\/td>\n<td>A4180-5<\/td>\n<td>SRT1720 HCl<\/td>\n<td>1001645-58-4<\/td>\n<td>SIRT1 activator<\/td>\n<\/tr>\n<tr>\n<td>A4182<\/td>\n<td>A4182-5.1<\/td>\n<td>Resveratrol<\/td>\n<td>501-36-0<\/td>\n<td>SIRT1 activator<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>SIRT1 \u6d3b\u5316\u5291(SIRT1 activator)-SRT1720 SRT1720 HCl| CAS#100 [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":47343,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5368],"tags":[6433],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/47728"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=47728"}],"version-history":[{"count":3,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/47728\/revisions"}],"predecessor-version":[{"id":47731,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/47728\/revisions\/47731"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/47343"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=47728"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=47728"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=47728"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}