{"id":45153,"date":"2023-08-17T16:40:09","date_gmt":"2023-08-17T08:40:09","guid":{"rendered":"https:\/\/biopioneer.com.tw\/?p=45153"},"modified":"2025-12-19T17:18:36","modified_gmt":"2025-12-19T09:18:36","slug":"poloxamer-407-cas-9003-11-6-mce%e8%b2%a8%e8%99%9f-hy-d1005","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=45153","title":{"rendered":"Poloxamer 407 | CAS#\u00a09003-11-6 MCE\u8ca8\u865f HY-D1005"},"content":{"rendered":"

MCE inhibitors\u53f0\u7063\u4ee3\u7406\u7d93\u92b7-<\/span>MCE (MedChem Express) -Poloxamer 407<\/span><\/span><\/strong><\/span><\/p>\n

MCE\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u65b0\u6fa4\u897f\uff0c\u63d0\u4f9b\u7a2e\u985e\u9f4a\u5168\u7684\u5316\u5b78\u53ca\u751f\u5316\u7814\u7a76\u7528\u7522\u54c1\uff0c\u5305\u62ec\u5275\u65b0\u7684\u751f\u547d\u79d1\u5b78\u8a66\u5291\uff0creference compounds(\u6a19\u6e96\u5316\u5408\u7269)\uff0cAPIs(\u539f\u6599\u85e5)\u53caNatural compounds(\u5929\u7136\u5316\u5408\u7269)\u4ee5\u63d0\u4f9b\u5be6\u9a57\u5ba4\u6216\u79d1\u5b78\u7814\u7a76\u4e4b\u7528\uff0cMedChemExpress(MCE)\u7522\u54c150000+ \u7279\u7570\u6027\u6291\u5236\u5291\u3001\u5316\u5408\u7269\u5eab\u3001\u91cd\u7d44\u86cb\u767d\uff0c\u5c08\u6ce8\u65bc\u4fe1\u865f\u901a\u8def\u548c\u75be\u75c5\u7814\u7a76\u9818\u57df\u3002\u5168\u7403\u6587\u737b\u5ee3\u6cdb\u5f15\u7528\uff0c\u8cea\u63a7\u9ad4\u7cfb\u56b4\u683c\uff0c\u54c1\u8cea100%\u3002<\/p>\n

Poloxamer 407 | CAS#\u00a09003-11-6 MCE\u8ca8\u865f HY-D1005<\/span><\/strong><\/span><\/a><\/p>\n

Poloxamer 407\u662f\u4e00\u7a2e\u975e\u96e2\u5b50\u8868\u9762\u6d3b\u6027\u5291(nonionic surfactant )\uff0c\u5177\u6709100% \u6d3b\u6027\uff0c\u5728\u4f4e\u6fc3\u5ea6\u4e0b\u5c0d\u7d30\u80de\u76f8\u5c0d\u7121\u6bd2\uff0c\u7d93\u5e38\u8207\u67d3\u6599AM \u916f(dye AM esters)\u4e00\u8d77\u4f7f\u7528\uff0c\u4f8b\u5982Indo-1 AM\u3001Fura-2 AM\u3001Calcein AM \u3001Fluo-3 AM\u3001Fluo -4 AM\u3001Quest Fluo-8\u2122 AM \u548c Quest Rhod-4\u2122 AM \u7b49\uff0c\u4ee5\u63d0\u9ad8\u5176\u6c34\u6eb6\u6027\u3002 Poloxamer 407 \u4e5f\u662f\u4e00\u7a2e\u8102\u86cb\u767d\u8102\u80aa\u9176\u6291\u5236\u5291(\u00a0lipoprotein lipase<\/b> inhibitor)\u3002<\/p>\n\n\n\n\n\n\n\n\n\n\n\n
Description<\/th>\n\n
\n

Poloxamer 407 is a nonionic surfactant that is 100% active and relatively non-toxic to cells at low concentrations, and frequently used with dye AM esters such as Indo-1 AM, Fura-2 AM, Calcein AM, Fluo-3 AM, Fluo-4 AM, Quest Fluo-8\u2122 AM and Quest Rhod-4\u2122 AM, etc. to improve their water solubility. Poloxamer 407 is also a\u00a0lipoprotein lipase<\/b>\u00a0inhibitor[1]<\/a><\/sup>[2]<\/a><\/sup>.<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

In Vitro<\/th>\n\n
\n

Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs).
\n1. Dissolve 1 g of Poloxamer 407 in 10 mL distilled water to make a 10% (w\/v) stock solution, or 2 g of Poloxamer 407 in 10 mL DMSO to make a 20% (w\/v) stock solution. These may require heating from 40 to 50\u00b0C for about 30 minutes. Store solution at room temperature. Do not refrigerate or freeze the Poloxamer 407 solution since it may precipitate. If precipitation is observed, the precipitates can be dissolved by heating to 37\u00b0C and vortexing before use.
\n2. Dilute the 10% or 20% Poloxamer 407 stock solution into the cell-loading buffer such as Hanks and 20 mM Hepes buffer (HHBS) at 1:1000 to 1:500 dilution to achieve a 0.02 to 0.04% working solution.
\n3. The DMSO stock solution of AM ester is then diluted into the 0.02 to 0.04% working solution to achieve a final AM ester concentration between 1 \u03bcM and 10 \u03bcM. The final concentration of Poloxamer 407 is normally kept at or below 0.08%.
\n4. The cells are incubated at a desired temperature for between 10 minutes and 1 hour. In general it is desirable to use the minimum amount of AM ester needed to achieve adequate fluorescence signal to noise levels.
\n5. After labeling, the cells are washed with HHBS or fresh medium before starting the experiment.<\/p>\n

MCE has not independently confirmed the accuracy of these methods. They are for reference only.<\/b><\/p>\n<\/div>\n<\/td>\n<\/tr>\n

In Vivo<\/th>\n\n
\n

Poloxamer 407 (0.25 g\/kg; i.p.; every other day for 7 weeks) induces hypertriglyceridemia but decreases atherosclerosis in Ldlr-\/-<\/sup>\u00a0mice[2]<\/a><\/sup>.<\/p>\n

MCE has not independently confirmed the accuracy of these methods. They are for reference only.<\/b><\/p>\n<\/div>\n<\/td>\n<\/tr>\n

Molecular Weight<\/th>\n\n
\n

12000(Average)<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

Appearance<\/th>\n\n
\n

Solid<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

CAS No.<\/th>\n\n
SMILES<\/th>\n\n
\n

CC.[H(OCH2CH2)x(OCH2CH)y(OCH2CH2)zOH].[CH3]<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

Shipping<\/th>\n\n
\n

Room temperature in continental US; may vary elsewhere.<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

Storage<\/th>\n\n
<\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\"\u7db2\u7ad9\u898f\u683c\u5c0f\u5716_\u5de5\u4f5c\u5340\u57df<\/a><\/p>\n

\"\"<\/p>\n

\"\u54c1\u724c\u4ecb\u7d39_\u5de5\u4f5c\u5340\u57df<\/p>\n

MCE\u53f0\u7063\u4ee3\u7406\u5546-BRAND\/AGENCY\/\u4ee3\u7406\u54c1\u724c\/<\/span>\u00a0MedChemexpress\uff08MCE\uff09\u53f0\u7063\u4ee3\u7406\u5546<\/span><\/span><\/strong><\/span><\/p>\n

https:\/\/www.medchemexpress.com\/\u00a0<\/a><\/span><\/p>\n

MCE\u53f0\u7063\u4ee3\u7406\u5546 MedChemexpress\uff08MCE\uff09\u63d0\u4f9b\u4e86\u4e00\u500b\u5ee3\u6cdb\u7684\u7814\u7a76\u5316\u5b78\u54c1\u548c\u751f\u5316\u7522\u54c1\uff0c\u5305\u62ec\u65b0\u7684\u751f\u547d\u79d1\u5b78\u8a66\u5291\uff0c\u53c3\u8003\u5316\u5408\u7269\uff0c\u539f\u6599\u85e5\u548c\u5929\u7136\u5316\u5408\u7269\u5be6\u9a57\u5ba4\u548c\u79d1\u5b78\u4f7f\u7528\u3002MedChemExpress (MCE)\u4f5c\u70ba\u5168\u7403\u9818\u5148\u7684\u79d1\u7814\u985e\u5316\u5b78\u54c1\u548c\u751f\u7269\u6d3b\u6027\u5316\u5408\u7269\u4f9b\u61c9\u5546\uff0c\u7522\u54c1\u7bc4\u570d\u5305\u542b\u5404\u7a2e\u6291\u5236\u5291(MCE inhibitors)\u3001\u5316\u5408\u7269\u3001\u5404\u7a2e\u6d3b\u6027\u5c0f\u5206\u5b50\u6291\u5236\u5291\u7b49\u3002\u3002MedChemexpress (MCE) \u64c1\u6709\u8cc7\u6df1\u767c\u7522\u6b77\u7a0b\u3001\u5c08\u696d\u7684\u5316\u5b78\u5bb6\u8207\u751f\u7269\u5b78\u5bb6\u83c1\u82f1\u5718\u968a\u3001\u4ee5\u53ca\u8c50\u5bcc\u7684\u884c\u696d\u7d93\u9a57\uff0c\u5f9e\u7522\u54c1\u7684\u6578\u64da\u89e3\u6790\u5230\u751f\u7269\u6d3b\u6027\u6578\u64da\uff0cMedChemexpress (MCE) \u90fd\u79c9\u6301\u8457\u7121\u6bd4\u5c08\u696d\u3001\u9ad8\u6548\u7387\u7684\u4f01\u696d\u7406\u5ff5\uff0c\u4e26\u4fdd\u6301\u5b8c\u5584\u7684\u7ba1\u7406\u9ad4\u7cfb\uff0c\u6301\u7e8c\u63d0\u4f9b\u4ee4\u4eba\u653e\u5fc3\u7684\u7522\u54c1\u8207\u670d\u52d9\u3002MCE\u9ad8\u5ea6\u91cd\u8996\u7d14\u5ea6\uff0c\u7a69\u5b9a\u6027\u548c\u6d3b\u6027\u7684\u5316\u5408\u7269\u3002\u7522\u54c1\u5305\u62ecAnti-infection\u3001\u00c1ntibody-drup conjugate\/ADC \u76f8\u95dc\u3001\u7d30\u80de\u51cb\u4ea1\u3001Autophagy\u3001Cell cycle\/DNA Damage\u3001GPCR\/G\u86cb\u767d\u3001\u514d\u75ab\/\u611f\u67d3\u3001JAK\/STAT Signaling\u3001MAPK\/ERK\u8def\u5f91\u3001\u4ee3\u8b1d\u9175\u7d20\u53caProtease\u3001NF-kB\u3001PROTAC\u3001Protein Tyrosin kinase\/RTK\u3001Stem Cell\/Wnt\u3001TGF-betat\/Smad\u7b49\u3002<\/p>\n

\"\"<\/p>\n

MedChemexpress (MCE) \u7522\u54c1<\/span><\/h4>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\u5316\u5408\u7269\u54c1\u724c<\/td>\n\u5316\u5408\u7269CAS\u865f<\/td>\n\u5316\u5408\u7269\u540d\u7a31<\/td>\n\u5316\u5408\u7269\u8ca8\u865f<\/td>\n\u5316\u5408\u7269\u4ecb\u7d39<\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#108321-42-2<\/td>\nG-418 disulfat<\/td>\nMCE\u8ca8\u865fHY-17561<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#68528-80-3<\/td>\nDSS Crosslinker (disuccinimidyl suberate)<\/td>\nMCE\u8ca8\u865fHY-W019543<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#1380723-44-3<\/td>\nAtezolizumab<\/td>\nMCE\u8ca8\u865fHY-P9904<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#1207456-01-6<\/td>\nTalazoparib (BMN-673; LT-673)<\/td>\nMCE\u8ca8\u865fHY-16106<\/span><\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#763113-22-0<\/td>\nOlaparib<\/td>\nMCE\u8ca8\u865fHY-10162<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#1382764-52-4<\/td>\nLipidGreen 2\u8102\u8cea\u6210\u50cf\u5c0f\u5206\u5b50\u63a2\u91dd<\/td>\nMCE\u8ca8\u865fHY-D1353<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#103404-75-7<\/td>\nD-\u87a2\u5149\u7d20(D-luciferin) \u6c34\u6eb6\u6027\u9209\u9e7d<\/td>\nMCE\u8ca8\u865fHY-12591<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#15144-35-9<\/td>\nD-\u87a2\u5149\u7d20(D-Luciferin potassium)<\/td>\nMCE\u8ca8\u865fHY-12591B<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#186689-07-6<\/td>\n2-NBDG\u6d3b\u7d30\u80de\u548c\u7d44\u7e54\u8461\u8404\u7cd6\u7684\u651d\u53d6<\/td>\nMCE\u8ca8\u865fHY-116215<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\n<\/td>\nIPTG\u00a0 ( Isopropyl \u03b2-D-thiogalactoside)<\/td>\nMCE\u8ca8\u865fHY-15921<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#10121-91-2<\/td>\n\u81ea\u566c\u6ce1(autophagic vacuoles)\u87a2\u5149\u6a19\u8a8c<\/td>\nMCE\u8ca8\u865fHY-D1027<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#28728-55-4<\/td>\n\u805a\u51dd\u80fa(Polybrene) \u967d\u96e2\u5b50\u805a\u5408\u7269<\/td>\nMCE\u8ca8\u865fHY-112735<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#288250-47-5<\/td>\nY-320 \u514d\u75ab\u8abf\u7bc0\u5291<\/td>\nMCE\u8ca8\u865fHY-15898<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#30931-67-0<\/td>\nABTS diammonium salt<\/td>\nMCE\u8ca8\u865fHY-15902<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#16561-29-8<\/td>\nPhorbol 12-myristate 13-acetate, PMA<\/td>\nMCE\u8ca8\u865fHY-18739<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#50-63-5<\/td>\n\u78f7\u9178\u6c2f\u55b9 Chloroquine phosphate<\/td>\nMCE\u8ca8\u865fHY-17589<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS# 9003-11-6<\/td>\nPoloxamer 407<\/td>\nMCE\u8ca8\u865fHY-D1005<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#150347-59-4<\/td>\nCFSE\u87a2\u5149\u67d3\u6599<\/td>\nMCE\u8ca8\u865fHY-D0938<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS# 9025-71-2<\/td>\n\u55ae\u5be7\u9176(Tannase)<\/td>\nMCE\u8ca8\u865fHY-P2877<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS# 941678-49-5<\/td>\nRuxolitinib<\/td>\nMCE\u8ca8\u865fHY-50856<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#9002-92-0<\/td>\nPolidocanol<\/td>\nMCE\u8ca8\u865fHY-B2106<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#HY-100579<\/td>\nFerrostatin-1 (Synonyms: Fer-1)<\/td>\nMCE\u8ca8\u865f HY-100579<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#154-23-4<\/td>\n\u5152\u8336\u7d20(Catechin)<\/td>\nMCE\u8ca8\u865f HY-N0898<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS# 2225728-57-2<\/td>\nFT895\u5f37\u6548\u9078\u64c7\u6027 HDAC11 \u6291\u5236\u5291<\/td>\nMCE\u8ca8\u865f HY-112285<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS# 5471-63-6<\/td>\n1,3-\u4e8c\u82ef\u57fa\u7570\u82ef\u4e26\u544b\u5583 (DPBF)<\/td>\nMCE\u8ca8\u865f HY-W011664<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS# 2225728-57-2<\/td>\nAkaLumine hydrochloride<\/td>\nMCE\u8ca8\u865fHY-112641A<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#203115-63-3<\/td>\nWRN \u89e3\u65cb\u9176\u6291\u5236\u5291NSC 617145<\/td>\nMCE\u8ca8\u865f \u00a0HY-110185<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#2244-11-3<\/td>\nAlloxan hydrate<\/td>\nMCE\u8ca8\u865fHY-W017227<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#23491-44-3<\/td>\nHoechst 33258<\/td>\nMCE\u8ca8\u865fHY-15558<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#18883-66-4<\/td>\nStreptozotocin<\/td>\nMCE\u8ca8\u865fHY-13753<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#554435-83-5<\/td>\nDeferasirox (Fe3+ chelate)<\/td>\nMCE\u8ca8\u865f\u00a0HY-16564<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

MCE inhibitors\u53f0\u7063\u4ee3\u7406\u7d93\u92b7-MCE (MedChem Express) -Poloxamer 4 […]<\/p>\n","protected":false},"author":3,"featured_media":54288,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5369],"tags":[6024],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/45153"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=45153"}],"version-history":[{"count":2,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/45153\/revisions"}],"predecessor-version":[{"id":54296,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/45153\/revisions\/54296"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/54288"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=45153"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=45153"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=45153"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}