{"id":44774,"date":"2023-08-02T21:23:52","date_gmt":"2023-08-02T13:23:52","guid":{"rendered":"https:\/\/biopioneer.com.tw\/?p=44774"},"modified":"2025-11-15T12:45:48","modified_gmt":"2025-11-15T04:45:48","slug":"%e8%a1%a8%e6%b2%92%e9%a3%9f%e5%ad%90%e5%85%92%e8%8c%b6%e7%b4%a0%e6%b2%92%e9%a3%9f%e5%ad%90%e9%85%b8%e9%85%af-egcg-cas989-51-5-apexbio%e8%b2%a8%e8%99%9fa2600","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=44774","title":{"rendered":"(-)-\u8868\u6c92\u98df\u5b50\u5152\u8336\u7d20\u6c92\u98df\u5b50\u9178\u916f (EGCG) | CAS#989-51-5 APExBIO\u8ca8\u865fA2600"},"content":{"rendered":"

(-)-\u8868\u6c92\u98df\u5b50\u5152\u8336\u7d20\u6c92\u98df\u5b50\u9178\u916f (EGCG) <\/span>–(-)-Epigallocatechin gallate (EGCG)<\/span><\/span><\/span><\/span><\/strong><\/span><\/p>\n

APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5291 (Small Molecule Inhibitors)\/\u6d3b\u5316\u5291 (Activators)\u3001\u5316\u5408\u7269\u5eab( Compound Libraries)\u3001\u80dc\u80bd(Peptides)\u3001\u6aa2\u6e2c\u8a66\u5291\u76d2(Assay Kits)\u3001\u87a2\u5149\u6a19\u8a18(Fluorescent Label)\u3001\u9176(Enzymes)\u3001\u4fee\u98fe\u6838\u82f7\u9178(Modified Nucleotides)\u3001mRNA \u5408\u6210\u4ee5\u53ca\u5404\u7a2e\u5206\u5b50\u751f\u7269\u5b78\u5de5\u5177\u7684\u4f9b\u61c9\u5546\u3002APExBIO\u63d0\u4f9b\u5ee3\u6cdb\u7684\u7522\u54c1\u7dda\uff0c\u6db5\u84cb 20 \u591a\u500b\u4e0d\u540c\u7684\u7814\u7a76\u9818\u57df\uff0c\u4f8b\u5982\u764c\u75c7(cancer)\u3001\u514d\u75ab\u5b78(immunology)\u3001\u795e\u7d93\u79d1\u5b78(neurosciences)\u3001\u7d30\u80de\u51cb\u4ea1(apoptosis)\u548c\u8868\u89c0\u907a\u50b3\u5b78(epigenetics)\u7b49\u3002\u516c\u53f8\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u5fb7\u5dde\u4f11\u58eb\u9813USA (Houston, Texas)\uff0c\u81f4\u529b\u65bc\u670d\u52d9\u5168\u7403\u5ba2\u6236\u3002\u9ad8\u5ea6\u91cd\u8996\u7522\u54c1\u54c1\u8cea\u3002\u6240\u6709\u7522\u54c1\u5747\u9075\u5faa\u56b4\u683c\u7684\u751f\u7522\u6307\u5357\uff0c\u4e26\u9644\u6709\u5206\u6790\u8b49\u66f8\u3001HPLC\u3001\u8cea\u8b5c(Mass Spectrum)\u548cHMNR\u4ee5\u53ca\u9ad4\u5916\u9a57\u8b49(in vitro validation)\u3002 APExBIO\u7522\u54c1\u5df2\u88ab\u300aNature\u300b\u3001\u300aCell\u300b\u548c\u300aScience\u300b\u7b49\u773e\u591a\u9802\u7d1a\u540c\u884c\u8a55\u5be9\u671f\u520a\u5f15\u7528\u3002<\/p>\n

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(-)-Epigallocatechin gallate (EGCG)| CAS#989-51-5 APExBIO\u8ca8\u865fA2600<\/span><\/a><\/span><\/strong><\/p>\n

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(-)-\u8868\u6c92\u98df\u5b50\u5152\u8336\u7d20\u6c92\u98df\u5b50\u9178\u916f((-)-Epigallocatechin gallate, EGCG)\u662f\u7da0\u8336\u4e2d\u4e3b\u8981\u7684\u5152\u8336\u7d20(green tea)\uff0c\u4f54\u7da0\u8336\u5152\u8336\u7d20\u7e3d\u91cf\u768459%\uff0c\u662f\u4e00\u7a2e\u5f37\u5927\u7684\u6297\u6c27\u5316\u5291(powerful antioxidant )\u3001\u6297\u8840\u7ba1\u751f\u6210\u5291(antiangiogenic)\u548c\u6297\u816b\u7624\u5291(antitumor agent)\u3002\u4eba\u5011\u5df2\u7d93\u7814\u7a76\u4e86 EGCG \u5728\u5316\u5b78\u9810\u9632\u591a\u7a2e\u764c\u75c7\u65b9\u9762\u7684\u4f5c\u7528\uff0c\u5305\u62ec\u809d\u764c( liver cancers)\u3001\u80c3\u764c( stomach cancers)\u3001\u76ae\u819a\u764c(skin cancers)\u3001\u80ba\u764c( lung cancers)\u3001\u4e73\u817a\u764c(mammary gland cancers)\u548c\u7d50\u8178\u764c(colon cancers)\u3002\u7814\u7a76\u7d50\u679c\u8868\u660e\uff0cEGCG\u80fd\u5920\u901a\u904e\u5f71\u97ff\u4fe1\u865f\u8f49\u5c0e\u9014\u5f91\u8a98\u5c0e\u7d30\u80de\u51cb\u4ea1(apoptosis)\u3001\u4fc3\u9032\u7d30\u80de\u751f\u9577\u505c(* cell growth arrest)\u4e26\u963b\u6b62\u764c\u8b8a(carcinogenesis )\u3002\u6b64\u5916\uff0cEGCG \u5c0d\u591a\u7a2e\u75c5\u6bd2\u5177\u6709\u6291\u5236\u4f5c\u7528\uff0c\u5305\u62ec HCV\u3001HIV-1\u3001HBV\u3001HSV-1\u3001HSV-2\u3001EBV\u3001\u817a\u75c5\u6bd2\u3001\u6d41\u611f\u75c5\u6bd2\u548c\u8178\u9053\u75c5\u6bd2\uff0c\u4ee5\u53ca\u591a\u7a2e\u9176\uff0c\u5305\u62ec DNMT\u3001\u86cb\u767d\u9176\u548c DHFR\u3002<\/p>\n

<\/p>\n<\/div>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Physical Appearance<\/td>\nA solid<\/td>\n<\/tr>\n
Storage<\/td>\nStore at -20\u00b0C<\/td>\n<\/tr>\n
M.Wt<\/td>\n458.37<\/td>\n<\/tr>\n
Cas No.<\/td>\n989-51-5<\/td>\n<\/tr>\n
Formula<\/td>\nC22<\/sub>H18<\/sub>O11<\/sub><\/td>\n<\/tr>\n
Synonyms<\/td>\nEGCG<\/td>\n<\/tr>\n
Solubility<\/td>\n\u226522.9 mg\/mL in DMSO; \u226510.9 mg\/mL in H2O with ultrasonic; \u22656.76 mg\/mL in EtOH with ultrasonic<\/td>\n<\/tr>\n
Chemical Name<\/td>\n[(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate<\/td>\n<\/tr>\n
SDF<\/td>\nDownload SDF<\/a><\/td>\n<\/tr>\n
Canonical SMILES<\/td>\nOC1=CC(O)=C(C[C@@H](OC(C2=CC(O)=C(O)C(O)=C2)=O)[C@@H](C3=CC(O)=C(O)C(O)=C3)O4)C4=C1<\/td>\n<\/tr>\n
Shipping Condition<\/td>\nSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.<\/td>\n<\/tr>\n
General tips<\/td>\nFor obtaining a higher solubility, please warm the tube at 37\u00b0C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
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(-)-Epigallocatechin gallate (EGCG)| CAS#989-51-5<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
Cell experiment [1]:<\/strong><\/td>\n<\/tr>\n
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Cell lines<\/p>\n<\/td>\n

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Human and rat neural progenitor cells (NPCs)<\/p>\n<\/td>\n<\/tr>\n

Preparation method<\/td>\nThe solubility of this compound in DMSO is >10 mM. General tips for obtaining a higher concentration: Please warm the tube at 37\u2103 for 10 minutes and\/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20\u2103 for several months.<\/td>\n<\/tr>\n
Reaction Conditions<\/td>\n0, 1, 2, 5 and 10 \u03bcM; 24 or 48 hrs<\/td>\n<\/tr>\n
Applications<\/td>\n(-)-Epigallocatechin Gallate (EGCG) altered human and rat NPC development in vitro. EGCG affected migration distance, migration pattern and nuclear density of NPCs growing as neurospheres. EGCG exerted these functional impairments by binding to the extracellular matrix (ECM) glycoprotein laminin, preventing its binding to \u03b21-integrin subunits, thereby prohibiting cell adhesion and resulting in altered glia alignment and decreased number of migrating young neurons.<\/td>\n<\/tr>\n
Animal experiment [2]:<\/strong><\/td>\n<\/tr>\n
Animal models<\/td>\nA rat model of partial bladder outlet obstruction (pBOO)-induced bladder injury<\/td>\n<\/tr>\n
Dosage form<\/td>\n4.5 mg\/kg\/day; i.p.; 2 days or 30 days<\/td>\n<\/tr>\n
Applications<\/td>\nEGCG attenuated bladder inflammation caused by pBOO at the 48th hr. At the 30th day, EGCG attenuated endoplasmic reticulum (ER) stress-related apoptosis. In addition, EGCG improved bladder compliance, contractile frequency and inflammation at the 30th day.<\/td>\n<\/tr>\n
Other notes<\/td>\nPlease test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div>\n

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APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002<\/p>\n

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(-)-\u8868\u6c92\u98df\u5b50\u5152\u8336\u7d20\u6c92\u98df\u5b50\u9178\u916f (EGCG) –(-)-Epigallocatechin gal […]<\/p>\n","protected":false},"author":3,"featured_media":47343,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5368],"tags":[6207],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/44774"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=44774"}],"version-history":[{"count":5,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/44774\/revisions"}],"predecessor-version":[{"id":53595,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/44774\/revisions\/53595"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/47343"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=44774"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=44774"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=44774"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}