{"id":44082,"date":"2023-07-17T16:53:25","date_gmt":"2023-07-17T08:53:25","guid":{"rendered":"https:\/\/biopioneer.com.tw\/?p=44082"},"modified":"2025-11-15T15:47:32","modified_gmt":"2025-11-15T07:47:32","slug":"nsc-74859-stat3-%e7%9a%84%e9%81%b8%e6%93%87%e6%80%a7%e6%8a%91%e5%88%b6%e5%8a%91-cas501919-59-1-apexbio%e8%b2%a8%e8%99%9fa8338","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=44082","title":{"rendered":"NSC 74859 ( S3I-201 Stat3 \u7684\u9078\u64c7\u6027\u6291\u5236\u5291) | CAS#501919-59-1 APExBIO\u8ca8\u865fA8338"},"content":{"rendered":"<p><span style=\"color: #993366;\"><strong><span style=\"font-size: 14pt;\"><span style=\"color: #800080;\">Stat3 \u7684\u9078\u64c7\u6027\u6291\u5236\u5291 (Stat3 inhibitor) <\/span><span style=\"color: #ff9900;\"><span style=\"color: #800080;\">-NSC 74859<br \/>\n<\/span><\/span><\/span><\/strong><\/span><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/2022\/09\/APExBIO_logo.jpg\" width=\"274\" height=\"64\" \/><\/p>\n<p><span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/www.apexbt.com\">https:\/\/www.apexbt.com<\/a><\/span><\/p>\n<p>APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002<a href=\"https:\/\/biopioneer.com.tw\/?news=apexbio%e5%8f%b0%e7%81%a3%e4%bb%a3%e7%90%86%e5%95%86-brandagency%e4%bb%a3%e7%90%86%e5%93%81%e7%89%8c-apexbio-2\"><span style=\"color: #ff0000;\"><em><strong><span style=\"text-decoration: underline;\">&gt;&gt;\u66f4\u591aAPExBio\u5546\u54c1<\/span><\/strong><\/em><\/span><\/a><\/p>\n<p><strong><span style=\"color: #33cccc;\"><a style=\"color: #33cccc;\" href=\"https:\/\/biopioneer.com.tw\/?p=44082&amp;preview=true\"><span style=\"font-size: 12pt;\">NSC 74859 ( Stat3 \u7684\u9078\u64c7\u6027\u6291\u5236\u5291) | CAS#501919-59-1 APExBIO\u8ca8\u865fA8338<\/span><\/a><\/span><\/strong><\/p>\n<p>S3I-201 \u662f Stat3 \u7684\u9078\u64c7\u6027\u6291\u5236\u5291\uff0cIC50 \u503c\u70ba 86 \u03bcM [1]\u3002<\/p>\n<p>\u5728\u9ad4\u5916 Stat3 DNA \u7d50\u5408\u6e2c\u5b9a(in vitro Stat3 DNA-binding assay)\u4e2d\uff0cS3I-201 \u986f\u793a\u51fa\u5c0d Stat3 DNA \u7d50\u5408\u6d3b\u6027\u7684\u6709\u6548\u6291\u5236\uff0c\u5e73\u5747 IC50 \u70ba 86 \u03bcM\u3002\u5728 EMSA \u6e2c\u5b9a\u4e2d\uff0c\u8207 Stat1 \u548c Stat5 \u76f8\u6bd4\uff0cS3I-201 \u9078\u64c7\u6027\u6291\u5236 Stat3 DNA \u7d50\u5408\u6d3b\u6027\u3002\u5b83\u6291\u5236 Stat1-Stat3 \u548c Stat1-Stat1 \u7684\u8907\u5408\u7269\u5f62\u6210\uff0cIC50 \u503c\u5206\u5225\u70ba 160 \u548c &gt; 300 \u03bcM\u3002\u9664\u6b64\u4e4b\u5916\uff0c\u672a\u78f7\u9178\u5316\u3001\u7121\u6d3b\u6027\u7684 Stat3 \u55ae\u9ad4\u88ab\u767c\u73fe\u53ef\u4ee5\u6062\u5fa9 S3I-201 \u6291\u5236\u7684 Stat3 DNA \u7d50\u5408\u6d3b\u6027\uff0c\u8868\u660e\u9019\u7a2e\u6291\u5236\u8207\u6fc0\u6d3b\u72c0\u614b\u7121\u95dc\u3002\u5728 NIH 3T3\/v-Src \u6210\u7e96\u7dad\u7d30\u80de\u4e2d\uff0cS3I-201 \u6291\u5236 Stat3 \u7684\u7d44\u6210\u578b\u6fc0\u6d3b\u4e26\u964d\u4f4e pTyr-705 Stat3 \u6c34\u5e73\u3002\u6b64\u5916\uff0cS3I-201\u88ab\u767c\u73fe\u5728\u6fc3\u5ea6\u70ba30-100 \u03bcM\u6642\u986f\u8457\u8a98\u5c0e\u5177\u6709\u6301\u7e8c\u6d3b\u6027Stat3\u7684\u7d30\u80de\u51cb\u4ea1\u3002 S3I-201 \u9084\u964d\u4f4e\u4e86\u9019\u4e9b\u7d30\u80de\u4e2d\u7d30\u80de\u9031\u671f\u86cb\u767d D1\u3001Bcl-xL \u548c\u5b58\u6d3b\u7684\u8868\u9054 [1]\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"https:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2023\/07\/2-NSC-74859-Stat3-%E7%9A%84%E9%81%B8%E6%93%87%E6%80%A7%E6%8A%91%E5%88%B6%E5%8A%91-CAS501919-59-1-APExBIO%E8%B2%A8%E8%99%9FA8338.jpg\" width=\"743\" height=\"521\" \/><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"https:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2023\/07\/3-NSC-74859-Stat3-%E7%9A%84%E9%81%B8%E6%93%87%E6%80%A7%E6%8A%91%E5%88%B6%E5%8A%91-CAS501919-59-1-APExBIO%E8%B2%A8%E8%99%9FA8338.jpg\" width=\"561\" height=\"457\" \/><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"https:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2023\/07\/4-NSC-74859-Stat3-%E7%9A%84%E9%81%B8%E6%93%87%E6%80%A7%E6%8A%91%E5%88%B6%E5%8A%91-CAS501919-59-1-APExBIO%E8%B2%A8%E8%99%9FA8338.jpg\" width=\"634\" height=\"646\" \/><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"https:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2023\/07\/5-NSC-74859-Stat3-%E7%9A%84%E9%81%B8%E6%93%87%E6%80%A7%E6%8A%91%E5%88%B6%E5%8A%91-CAS501919-59-1-APExBIO%E8%B2%A8%E8%99%9FA8338.jpg\" width=\"643\" height=\"568\" \/><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"https:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2023\/07\/6-NSC-74859-Stat3-%E7%9A%84%E9%81%B8%E6%93%87%E6%80%A7%E6%8A%91%E5%88%B6%E5%8A%91-CAS501919-59-1-APExBIO%E8%B2%A8%E8%99%9FA8338.jpg\" width=\"591\" height=\"453\" \/><\/p>\n<div id=\"cite\" class=\"tbar\">\n<h2><span style=\"color: #800000;\"><strong><span style=\"font-size: 12pt;\">Product Citation<\/span><\/strong><\/span><\/h2>\n<\/div>\n<div class=\"detail-table \">\n<div class=\"detail-box-cont\">\n<ul id=\"artul\">\n<li><a>1. Qi Yuan, Jianchun Gu, et al. &#8220;MyD88 in myofibroblasts enhances colitis-associated tumorigenesis via promoting macrophage M2 polarization.&#8221; Cell Rep. 2021 Feb 2;34(5):108724.<\/a>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/33535045\" target=\"_blank\" rel=\"noopener\">PMID:33535045<\/a><\/li>\n<li><a>2. Deng R, Zhang P, et al. &#8220;HDAC is indispensable for IFN-\u03b3-induced B7-H1 expression in gastric cancer.&#8221; Clin Epigenetics. 2018 Dec 11;10(1):153.<\/a>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30537988\" target=\"_blank\" rel=\"noopener\">PMID:30537988<\/a><\/li>\n<li><a>3. Xu J, Li Y, et al. &#8220;Baicalin regulates SirT1\/STAT3 pathway and restrains excessive hepatic glucose production.&#8221;Pharmacol Res. 2018 Aug 23;136:62-73.<\/a>\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30144531\" target=\"_blank\" rel=\"noopener\">PMID:30144531<\/a><\/li>\n<li><a>4. Yang L, Xu J, et al. &#8220;Porcine epidemic diarrhea virus-induced epidermal growth factor receptor activation impairs the antiviral activity of type I interferon.&#8221; J Virol. 2018 Jan 31. pii: JVI.02095-17.<\/a>\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29386292\" target=\"_blank\" rel=\"noopener\">PMID:29386292<\/a><\/li>\n<li><a>5. Zhang ZL, Jiang QC, et al. &#8220;Schisandrin A reverses doxorubicin-resistant human breast cancer cell line by the inhibition of P65 and Stat3 phosphorylation.&#8221; Breast Cancer. 2017 Nov 27.<\/a>\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29181822\" target=\"_blank\" rel=\"noopener\">PMID:29181822<\/a><\/li>\n<li><a>6. Marie R.Mooney.&#8221;Precision Medicine Approaches to Integrating Genomics with Cancer Therapy: Applications in Glioblastoma and Lymphoma.&#8221; ProQuest LLC. 2016.<\/a><\/li>\n<\/ul>\n<\/div>\n<\/div>\n<table>\n<tbody>\n<tr>\n<td>Storage<\/td>\n<td>Store at -20\u00b0C<\/td>\n<\/tr>\n<tr>\n<td>M.Wt<\/td>\n<td>365.36<\/td>\n<\/tr>\n<tr>\n<td>Cas No.<\/td>\n<td>501919-59-1<\/td>\n<\/tr>\n<tr>\n<td>Formula<\/td>\n<td>C<sub>16<\/sub>H<sub>15<\/sub>NO<sub>7<\/sub>S<\/td>\n<\/tr>\n<tr>\n<td>Synonyms<\/td>\n<td>S3I-201;NSC74859;NSC-74859;S3I 201<\/td>\n<\/tr>\n<tr>\n<td>Solubility<\/td>\n<td>insoluble in H2O; \u226518.25 mg\/mL in DMSO; \u22652.2 mg\/mL in EtOH with gentle warming<\/td>\n<\/tr>\n<tr>\n<td>Chemical Name<\/td>\n<td>2-hydroxy-4-[[2-(4-methylphenyl)sulfonyloxyacetyl]amino]benzoic acid<\/td>\n<\/tr>\n<tr>\n<td>SDF<\/td>\n<td><a href=\"https:\/\/www.apexbt.com\/downloader\/sdf\/A8338.sdf\">Download SDF<\/a><\/td>\n<\/tr>\n<tr>\n<td>Canonical SMILES<\/td>\n<td>CC1=CC=C(C=C1)S(=O)(=O)OCC(=O)NC2=CC(=C(C=C2)C(=O)O)O<\/td>\n<\/tr>\n<tr>\n<td>Shipping Condition<\/td>\n<td>Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.<\/td>\n<\/tr>\n<tr>\n<td>General tips<\/td>\n<td>For obtaining a higher solubility, please warm the tube at 37\u00b0C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><a href=\" http:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2023\/07\/1-NSC-74859-Stat3-\u7684\u9078\u64c7\u6027\u6291\u5236\u5291-CAS501919-59-1-APExBIO\u8ca8\u865fA8338.pdf\"><img decoding=\"async\" loading=\"lazy\" class=\"alignnone\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/2023\/01\/%E7%B6%B2%E7%AB%99%E8%A6%8F%E6%A0%BC%E5%B0%8F%E5%9C%96_%E5%B7%A5%E4%BD%9C%E5%8D%80%E5%9F%9F-1_%E5%B7%A5%E4%BD%9C%E5%8D%80%E5%9F%9F-11-300x97.jpg\" alt=\"\u7db2\u7ad9\u898f\u683c\u5c0f\u5716_\u5de5\u4f5c\u5340\u57df 1_\u5de5\u4f5c\u5340\u57df 1\" width=\"149\" height=\"48\" \/><\/a><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/2022\/09\/APExBIO_logo.jpg\" width=\"286\" height=\"58\" \/><\/p>\n<p><span style=\"color: #800000;\"><strong><span style=\"font-size: 12pt;\"><a style=\"color: #800000;\" href=\"http:\/\/www.apexbt.com\/\">APExBIO\u53f0\u7063\u4ee3\u7406\u5546<\/a><\/span><\/strong><\/span><\/p>\n<p><span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/www.apexbt.com\">https:\/\/www.apexbt.com<\/a><\/span><\/p>\n<p>APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Stat3 \u7684\u9078\u64c7\u6027\u6291\u5236\u5291 (Stat3 inhibitor) -NSC 74859 https:\/\/www. [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":47343,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5368],"tags":[5928],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/44082"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=44082"}],"version-history":[{"count":4,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/44082\/revisions"}],"predecessor-version":[{"id":53755,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/44082\/revisions\/53755"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/47343"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=44082"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=44082"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=44082"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}