{"id":43226,"date":"2023-06-18T11:47:11","date_gmt":"2023-06-18T03:47:11","guid":{"rendered":"https:\/\/biopioneer.com.tw\/?p=43226"},"modified":"2025-11-15T15:49:03","modified_gmt":"2025-11-15T07:49:03","slug":"ionomycin-calcium-salt-cas56092-82-1-apexbio%e8%b2%a8%e8%99%9fb5165","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=43226","title":{"rendered":"\u96e2\u5b50\u9ef4\u7d20\u9223\u9e7d | Ionomycin calcium salt CAS#56092-82-1 APExBIO\u8ca8\u865fB5165"},"content":{"rendered":"

\u96e2\u5b50\u8f09\u9ad4(Ionophores) <\/span>–<\/span>\u96e2\u5b50\u9ef4\u7d20\u9223\u9e7d(Ionomycin calcium salt)<\/span><\/span><\/strong><\/span><\/p>\n

Ionomycin calcium salt CAS#56092-82-1 APExBIO\u8ca8\u865fB5165<\/span><\/a><\/span><\/strong><\/p>\n

\u96e2\u5b50\u8f09\u9ad4(Ionophores)\u662f\u4fc3\u9032\u96e2\u5b50\u8de8\u751f\u7269\u819c\u8f49\u904b( ions across biological membranes)\u7684\u5206\u5b50\u3002 ion\u548cphero\u9019\u5169\u500b\u8a5e\u6e90\u81ea\u5e0c\u81d8\u8a9e\u201c\u53bb\u201d\u548c\u201c\u651c\u5e36\u201d\u3002\u96e2\u5b50\u8f09\u9ad4\u7684\u5b57\u9762\u610f\u601d\u662f\u96fb\u8377\u8f09\u9ad4\u3002\u96e2\u5b50\u8f09\u9ad4\u6539\u8b8a\u96fb\u5316\u5b78\u68af\u5ea6( electrochemical gradient)\u4e26\u6539\u8b8a\u7d30\u80de\u7684\u751f\u7406\u72c0\u614b\uff0c\u4f8b\u5982\u6c27\u5316\u78f7\u9178\u5316(oxidative phosphorylation)\u3001\u6ef2\u900f\u5e73\u8861( osmotic balance)\u3001\u795e\u7d93\u50b3\u905e(neurotransmission)\u3001\u7d30\u80de\u4fe1\u865f\u50b3\u5c0e(cell signaling)\u3001\u6fc0\u7d20\u4f5c\u7528(hormone action)\u7b49\u3002\u96e2\u5b50\u8f09\u9ad4(Ionophores)\u5177\u6709\u8a31\u591a\u751f\u7269\u5b78\u548c\u7814\u7a76\u61c9\u7528\u3002\u773e\u6240\u5468\u77e5\u7684\u96e2\u5b50\u8f09\u9ad4(Ionophores)\u6297\u751f\u7d20\u5305\u62ec \u7e88\u6c28\u9ef4\u7d20( Valinomycin )\u3001Gramicidin\u3001Nigericin\u3001Monensin \u548c Monactin<\/span>\uff0c\u5b83\u5011\u901a\u904e\u6539\u8b8a\u96e2\u5b50\u68af\u5ea6\u6bba\u6b7b\u7d30\u80de\u3002\u7e88\u6c28\u9ef4\u7d20( Valinomycin )\u5c08\u9580\u8f49\u904b\u9240\uff0c\u800c\u5176\u4ed6\u8f49\u904b\u55ae\u50f9\u967d\u96e2\u5b50\uff0c\u5982\u9209\u3001\u9240\u3001\u6c2b\u548c\u92a8\u96e2\u5b50\u3002\u77ed\u687f\u83cc\u80bd\u7528\u4f5c\u5c40\u90e8\u6297\u751f\u7d20\u4e26\u5b58\u5728\u65bc\u773c\u85e5\u6db2(ophthalmic solutions)\u4e2d\u3002\u96e2\u5b50\u8f09\u9ad4(Ionophores)\u5ee3\u6cdb\u7528\u65bc\u5bb6\u79bd\u4ee5\u63a7\u5236\u7531\u5bc4\u751f\u87f2\u5f15\u8d77\u7684\u7403\u87f2\u75c5\u3002\u83ab\u80fd\u83cc\u7d20(Monensin)\u662f\u7b2c\u4e00\u500b\u7528\u65bc\u6cbb\u7642\u7403\u87f2\u75c5(coccidiosis)\u7684\u96e2\u5b50\u8f09\u9ad4\u3002\u4e00\u4e9b\u96e2\u5b50\u8f09\u9ad4\u9084\u986f\u793a\u51fa\u5c0d\u764c\u75c7\u5e79\u7d30\u80de\u6a23\u7d30\u80de\u7684\u6709\u6548\u6297\u764c\u6d3b\u6027\u3002 Salinomycin\u3001Nigericin \u548c Lasolocid \u7b49\u96e2\u5b50\u8f09\u9ad4\u5df2\u5728\u81e8\u5e8a\u524d\u764c\u75c7\u6a21\u578b\u4e2d\u53d6\u5f97\u6210\u529f\uff0c\u4e26\u6b63\u5728\u81e8\u5e8a\u8a66\u9a57\u4e2d\u9032\u884c\u8a55\u4f30\u3002<\/p>\n

\u8a31\u591a\u96e2\u5b50\u8f09\u9ad4\u7528\u4f5c\u7814\u7a76\u96e2\u5b50\u50b3\u8f38\u548c\u6539\u8b8a\u7d30\u80de\u751f\u7406\u904e\u7a0b\u7684\u7814\u7a76\u5de5\u5177\u3002 Ionomycin \u662f\u4e00\u7a2e\u9223\u96e2\u5b50\u8f09\u9ad4\uff0c\u5e38\u7528\u65bc\u7814\u7a76\u7d30\u80de\u4e2d\u7684\u9223\u6d41\u3002 Carbonyl Cyanide m-Chlorophenylhydrazone (CCCP) \u662f\u4e00\u7a2e\u6c2b\u96e2\u5b50\u8f09\u9ad4\uff0c\u53ef\u5728\u6c27\u5316\u78f7\u9178\u5316\u904e\u7a0b\u4e2d\u5c0e\u81f4\u8cea\u5b50\u68af\u5ea6\u89e3\u5076\u806f\u3002 CCCP \u7528\u65bc\u7dda\u7c92\u9ad4\u819c\u96fb\u4f4d\u6e2c\u5b9a\u3002 Ionomycin \u548c Monensin \u6df7\u5408\u4f7f\u7528\u53ef\u8a98\u5c0e\u7d30\u80de\u56e0\u5b50\u7522\u751f\u4e26\u6291\u5236\u7d30\u80de\u5167\u8f49\u904b\u3002>>\u66f4\u591aAPExBio\u5546\u54c1<\/span><\/strong><\/em><\/span><\/a><\/p>\n

<\/p>\n

Ionomycin calcium salt\u7522\u54c1\u4ecb\u7d39<\/span><\/strong><\/span><\/p>\n

\u96e2\u5b50\u9ef4\u7d20\u9223\u9e7d\u662f\u4e00\u7a2e\u9223\u96e2\u5b50\u8f09\u9ad4[1]\u3002<\/p>\n

<\/p>\n

Ca2+ \u96e2\u5b50\u8f09\u9ad4(Ca2+ ionophore)\u5145\u7576 Ca2+ \u96e2\u5b50\u8f09\u9ad4(Ca2+ ionophore)\uff0c\u5141\u8a31 Ca2+ \u7a7f\u904e\u7d30\u80de\u819c\u3002\u96e2\u5b50\u9ef4\u7d20\u9223\u9e7d(Ionomycin calcium salt)\u662f\u4e00\u7a2e\u9223\u96e2\u5b50\u8f09\u9ad4\u3002\u5728\u57f9\u990a\u7684chicken pectoralis muscle\u4e2d\uff0cionomycin (10-6-10-5 M) \u9078\u64c7\u6027\u5730\u589e\u52a0\u86cb\u6c28\u9178\u647b\u5165\u5169\u7a2e\u86cb\u767d\u8cea\u3002 Ionomycin \u589e\u52a0\u7d30\u80de\u5916 Ca2+ \u7684\u6d41\u5165\u4e26\u589e\u52a0\u7d30\u80de\u8cea(cytoplasm)\u4e2d Ca2+ \u7684\u6fc3\u5ea6\uff0c\u5f9e\u800c\u8abf\u7bc0\u808c\u8089\u86cb\u767d\u7684\u5408\u6210 [2]\u3002\u5728\u5927\u9f20\u816e\u817a\u4e2d\uff0cionomycin \u589e\u52a0 86Rb \u5916\u6392\u300122Na \u651d\u53d6\u548c 3H-\u86cb\u767d\u5206\u6ccc\uff0c\u9019\u4f9d\u8cf4\u65bc\u589e\u52a0\u7d30\u80de\u6eb6\u8cea Ca2+\u3002\u5728\u816e\u817a\u7d30\u80de\u4e2d\uff0c\u96e2\u5b50\u9ef4\u7d20(ionomycin)\u91cb\u653e\u53d7\u9ad4\u8abf\u7bc0\u7684\u7d30\u80de Ca2+ \u5eab [3]\u3002\u5728\u4eba\u8180\u80f1\u764c\u7d30\u80de HT1376( human bladder cancer cells , HT1376)\u4e2d\uff0c\u96e2\u5b50\u9ef4\u7d20( ionomycin)\u4ee5\u6642\u9593\u548c\u5291\u91cf\u4f9d\u8cf4\u6027\u65b9\u5f0f\u986f\u8457\u6291\u5236\u7d30\u80de\u751f\u9577\uff0c\u4e26\u8a98\u5c0e\u51cb\u4ea1 DNA \u964d\u89e3\u3002\u6b64\u5916\uff0c\u96e2\u5b50\u9ef4\u7d20( ionomycin)\u964d\u4f4e\u4e86 Bcl-2 \u8207 Bax mRNA \u548c\u86cb\u767d\u8cea\u7684\u6bd4\u7387 [4]\u3002\u5728\u651c\u5e36 HT1376 \u816b\u7624\u7684\u7121\u80f8\u817a\u88f8\u9f20(athymic nude mice )\u4e2d\uff0c\u96e2\u5b50\u9ef4\u7d20\u986f\u8457\u6291\u5236\u816b\u7624\u751f\u9577\u4e26\u964d\u4f4e\u81f4\u7624\u6027( tumorigenicity) [4]\u3002<\/p>\n

\u96e2\u5b50\u9ef4\u7d20( ionomycin )\u4ee5\u5291\u91cf\u548c\u6642\u9593\u4f9d\u8cf4\u6027\u65b9\u5f0f\u6291\u5236 HT1376 \u7d30\u80de\u7684\u9ad4\u5916\u751f\u9577\u901f\u7387\u3002\u5728\u7528 10 \u03bcg\/ml ionomycin \u9023\u7e8c\u8655\u7406\u5f8c\uff0c\u5728 HT1376 \u7d30\u80de\u4e2d\u53ef\u4ee5\u89c0\u5bdf\u5230\u7279\u5fb5\u6027\u7684\u51cb\u4ea1 DNA \u964d\u89e3\uff0c\u4ee5\u53ca Bcl-2 \u8207 Bax mRNA \u548c\u86cb\u767d\u8cea\u7684\u6bd4\u7387\u986f\u8457\u964d\u4f4e\u3002<\/p>\n

<\/p>\n

References:
\n[1].\u00a0 Liu C, Hermann TE. Characterization of ionomycin as a calcium ionophore. J Biol Chem, 1978, 253(17): 5892-5894.
\n[2].\u00a0 Roufa D, Wu FS, Martonosi AN. The effect of Ca2+ ionophores upon the synthesis of proteins in cultured skeletal muscle. Biochim Biophys Acta, 1981, 674(2): 225-237.
\n[3].\u00a0 Poggioli J, Leslie BA, McKinney JS, et al. Actions of ionomycin in rat parotid gland. J Pharmacol Exp Ther, 1982, 221(1): 247-253.
\n[4].\u00a0 Miyake H, Hara I, Yamanaka K, et al. Calcium ionophore, ionomycin inhibits growth of human bladder cancer cells both in vitro and in vivo with alteration of Bcl-2 and Bax expression levels. J Urol, 1999, 162(3 Pt 1): 916-921.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Physical Appearance<\/td>\nA crystalline solid<\/td>\n<\/tr>\n
Storage<\/td>\nDesiccate at -20\u00b0C<\/td>\n<\/tr>\n
M.Wt<\/td>\n747.08<\/td>\n<\/tr>\n
Cas No.<\/td>\n56092-82-1<\/td>\n<\/tr>\n
Formula<\/td>\nC41<\/sub>H70<\/sub>O9<\/sub>\u00b7Ca<\/td>\n<\/tr>\n
Solubility<\/td>\nSoluble in DMSO<\/td>\n<\/tr>\n
Chemical Name<\/td>\ncalcium (4S,6S,8S,10E,12R,14R,16E,18S,19S,20R,21S)-19,21-dihydroxy-22-((2R,2’R,5R,5’S)-5′-((R)-1-hydroxyethyl)-2,5′-dimethyloctahydro-[2,2′-bifuran]-5-yl)-4,6,8,12,14,18,20-heptamethyl-11-oxido-9-oxodocosa-10,16-dienoate<\/td>\n<\/tr>\n
SDF<\/td>\nDownload SDF<\/a><\/td>\n<\/tr>\n
Canonical SMILES<\/td>\nO[C@H](C)[C@@]1(C)O[C@H](CC1)[C@]2(C)O[C@@H](C[C@@H]([C@@H](C)[C@H]([C@H](\/C=C\/C[C@@H](C)C[C@@H](C)\/C([O-])=C\\C([C@@H](C)C[C@@H](C)C[C@@H](C)CCC([O-])=O)=O)C)O)O)CC2.[Ca+2]<\/td>\n<\/tr>\n
Shipping Condition<\/td>\nSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.<\/td>\n<\/tr>\n
General tips<\/td>\nFor obtaining a higher solubility, please warm the tube at 37\u00b0C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\"\u7db2\u7ad9\u898f\u683c\u5c0f\u5716_\u5de5\u4f5c\u5340\u57df<\/a><\/p>\n

<\/p>\n

APExBIO\u53f0\u7063\u4ee3\u7406\u5546<\/a><\/span><\/strong><\/span><\/p>\n

https:\/\/www.apexbt.com<\/a><\/span><\/p>\n

APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u96e2\u5b50\u8f09\u9ad4(Ionophores) –\u96e2\u5b50\u9ef4\u7d20\u9223\u9e7d(Ionomycin calcium salt) […]<\/p>\n","protected":false},"author":3,"featured_media":34299,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5368],"tags":[5862],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/43226"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=43226"}],"version-history":[{"count":6,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/43226\/revisions"}],"predecessor-version":[{"id":53758,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/43226\/revisions\/53758"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/34299"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=43226"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=43226"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=43226"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}